Effect of 5-HT2A Receptor Polymorphisms, Work Stressors, and Social Support on Job Strain among Petroleum Workers in Xinjiang, China

Abstract

Previous studies have shown that work stressors and social support influence job strain. However, few studies have examined the impact of individual differences on job strain. In Xinjiang, there are a large number of petroleum workers in arid deserts. The present study investigated the effects of work stressors, social support, and 5-hydroxytryptamine receptor (5-HTR2A) genotype on the etiology of job strain among petroleum workers in Xinjiang. A cross-sectional study was carried out between January and August 2013. A total of 700 workers were selected by a three-stage stratified sampling method. 5-HTR2A genotypes were determined with the SNaPshot single nucleotide polymorphism assay. Work stressors and job strain were evaluated with the Occupational Stress Inventory-Revised questionnaire. Social support was assessed with the Chinese Social Support Rating Scale. Work overload and responsibility were significantly associated with job strain. Low social support was associated with severe vocational and interpersonal strain. High social support was a protective factor against job strain (odds ratio (OR) = 0.32, 95% confidence interval (CI): 0.14–0.76). The CC genotype of rs6313 and the AA genotype of rs2070040 were linked to severe vocational strain. Ordinal logistic regression analysis revealed that the CC genotype of rs6313 was linked to higher risk of job strain than the TT genotype (OR = 1.88, 95% CI: 1.10–3.23). These data provide evidence that work stressors, low social support, and 5-HTR2A gene polymorphism contributes to the risk of job strain.

Associations between erectile dysfunction and psychological disorders (depression and anxiety): A cross‐sectional study in a Chinese population

“…Hence, the causes of high incidences of anxiety and depression in young ED men might be due to the heavy burden of life and work pressure. Many previous studies have shown that high life and work pressure may have harmful effects on psychological health (Harvey et al, ; Jiang et al, , ; Tao, Zhang, Song, Tang, & Liu, ).…”

Cross-Sectional Survey on the Relationship Between Occupational Stress, Hormone Levels, and the Sleep Quality of Oilfield Workers in Xinjiang, China

“…Higher ORQ scores indicate more demanding tasks, higher PSQ scores indicate higher levels of stress, and higher PRQ scores indicate a stronger ability to respond to occupational stress. By grouping the subjects’ occupational stress according to the PRQ score [40] and the occupational stress norm [41], based on the formula T = 50 + 10 (Χ−trueΧ¯)/s (i.e., where Χ represents each sub-item, Χ¯ is the norm average, and s is the norm standard deviation), the original score of the subscale is converted into the T value. A T value ≥70 is classified as high occupational stress; 60 to 69 points indicate moderate occupational stress; and ≤59 points indicates low occupational stress.…”

Relationship between Occupational Stress, 5-HT2A Receptor Polymorphisms and Mental Health in Petroleum Workers in the Xinjiang Arid Desert: A Cross-Sectional Study

“…Several studies have reported that mental and physical health are affected by natural conditions including the monotonous lifestyle of arid deserts and other harsh environments [ 27 , 28 ]. Due to the socioeconomic impact of occupational stress [ 29 ], the majority of research studies have focused on white-collar workers [ 30 , 31 ] although few studies have examined the relationship between occupational stress, 5-HTR2A polymorphism, and mental health in petroleum workers stationed in arid deserts [ 32 , 33 ]. This research conducted a cross-sectional study of petroleum workers in Xinjiang to investigate: (1) the relationship between occupational stress and mental health; and (2) the relationship between 5-HTR2A polymorphism and mental health.…”