2020
DOI: 10.1016/j.bbr.2020.112780
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Effect of 5-HT2C receptor agonist and antagonist on chronic unpredictable stress (CUS) - Mediated anxiety and depression in adolescent Wistar albino rat: Implicating serotonin and mitochondrial ETC-I function in serotonergic neurotransmission

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Cited by 20 publications
(6 citation statements)
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“…Secreted from the HPA (hypothalamic-pituitary-adrenal) axis, cortisol is a physiological biomarker of stress level. It has been confirmed in most studies ( 38 41 ) that higher levels of serotonin activity lead to decreased depression and anxiety.…”
Section: Discussionmentioning
confidence: 80%
“…Secreted from the HPA (hypothalamic-pituitary-adrenal) axis, cortisol is a physiological biomarker of stress level. It has been confirmed in most studies ( 38 41 ) that higher levels of serotonin activity lead to decreased depression and anxiety.…”
Section: Discussionmentioning
confidence: 80%
“…As shown in Table 4 , the majority of the included studies provide evidence that, irrespective of their specific type, tryptamines have the potential to enhance aspects of neuroplasticity (Catlow, Song, Paredes, Kirstein, & Sanchez-Ramos, 2013; Dunlap et al, 2020; Katchborian-Neto et al, 2020; Lima da Cruz et al, 2018; Ly et al, 2018; Marton et al, 2019; Morales-Garcia et al, 2020). Remaining studies, although not directly assessing neurogenesis, reported no adverse effects on behavior or cellular physiology (Castro-Neto et al, 2013; Wankhar, Syiem, Pakyntein, Thabah, & Sunn, 2020; Winne et al, 2020). For instance, Catlow et al (2013) discovered that a single low dose (0.1-0.5 mg/kg) of psilocybin, administered 24 hours prior to a Trace Fear Conditioning test, initially heightened fear response but facilitated fear extinction by the third trial, an effect not observed until the tenth trial in control animals.…”
Section: Resultsmentioning
confidence: 99%
“…To determine the serum activity of GPx, SOD, and CAT, commercially available ELISA kits were used, including catalog number E-EL-R2491 from Elabscience (USA) for GPx, catalog number E-EL-R1424 from Elabscience (USA) for SOD, and catalog number ab100764 from Abcam (USA) for CAT. The measurement process followed the manufacturer's instructions and protocol (Wankhar et al, 2020).…”
Section: Serum Activity Of Superoxide Dismutase (Sod) Glutathione Per...mentioning
confidence: 99%