Effect of 5‐Hydroxytryptamine on Steroidogenesis and Oocyte Maturation in Pre‐ovulatory Follicles of the Medaka <i>Oryzias latipes</i>

Isobe, Takashi; Toya, Yoshiaki; Sakai, Noriyoshi; Terada, Yasutaka; Nagata, Rieko; Nagahama, Yoshitaka

doi:10.1111/j.1440-169x.1993.00625.x

Cited by 36 publications

(14 citation statements)

References 18 publications

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“…In contrast to the observed inhibitory influence in killifish, 10 µg/L and 100 µg/L of 5-HT had a stimulatory effect on oocyte maturation in Japanese medaka in vitro by inducing synthesis of estradiol and MIS in granulosa cells, resulting in germinal vesicle breakdown. 164 Overall, these studies demonstrate the complexity of serotonergic actions involved in the control of the HPG axis in fish. Moreover, the modulatory function of 5-HT appears to be largely dependent on reproductive status and may vary considerably in different fish species.…”

Section: Role Of 5-ht In Reproductive Processesmentioning

confidence: 81%

Physiological Endpoints for Potential SSRI Interactions in Fish

Kreke

Dietrich

2008

Critical Reviews in Toxicology

115

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Selective serotonin reuptake inhibitors (SSRIs) are among the pharmaceutical compounds frequently detected in sewage treatment plant effluents and surface waters, albeit at very low concentrations, and have therefore become a focus of interest as environmental pollutants. These neuroactive drugs are primarily used in the treatment of depression but have also found broader use as medication for other neurological dysfunctions, consequently resulting in a steady increase of prescriptions worldwide. SSRIs, via inhibition of the serotonin (5-hydroxytryptamine, 5-HT) reuptake mechanism, induce an increase in extracellular 5-HT concentration within the central nervous system of mammals. The phylogenetically ancient and highly conserved neurotransmitter and neurohormone 5-HT has been found in invertebrates and vertebrates, although its specific physiological role and mode of action is unknown for many species. Consequently, it is difficult to assess the impact of chronic SSRI exposure in the environment, especially in the aquatic ecosystem. In view of this, the current knowledge of the functions of 5-HT in fish physiology is reviewed and, via comparison to the physiological role and function of 5-HT in mammals, a characterization of the potential impact of chronic SSRI exposure on fish is provided. Moreover, the insight on the physiological function of 5-HT strongly suggests that the experimental approaches currently used are inadequate if not entirely improper for routine environmental risk assessment of pharmaceuticals (e.g., SSRIs), as relevant endpoints are not assessed or impossible to determine.

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Section: Role Of 5-ht In Reproductive Processesmentioning

confidence: 81%

Physiological Endpoints for Potential SSRI Interactions in Fish

Kreke

Dietrich

2008

Critical Reviews in Toxicology

115

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“…The SSRIs also have been measured in several species of fish collected from municipal effluent-dominated streams [2,11], indicating the potential problem that SSRIs may impose on the environment. Serotonin is assumed to be an important, ubiquitous neuromodulator in all vertebrates and invertebrates, and studies indicate that increased 5-HT concentrations stimulate gonadotropin secretion from the pituitary gland of the Japanese medaka, Oryzias latipes, which further increases gonad steroidogenesis [4,12]. In another fish species, Fundulus heteroclitus, increased levels of 5-HT inhibited oocyte maturity [13], but the response of oocytes to 5-HT varies among species [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Environmental risk assessment of three selective serotonin reuptake inhibitors in the aquatic environment: A case study including a cocktail scenario

Styrishave

Halling-Sørensen

Ingerslev

2011

Environmental Toxicology and Chemistry

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We present an environmental risk assessment of three selective serotonin reuptake inhibitors (SSRIs; citalopram, sertraline, and fluoxetine) in the aquatic environment based on two case scenarios. Abiotic and biotic degradation experiments and sorption estimates were used to predict environmental concentrations of three SSRIs from the wastewater of two psychiatric hospitals, the primary sector, and wastewater entering and leaving wastewater treatment plants (WWTPs). Assuming a sewage treatment retention time of 8 h, abiotic degradation was low, for all three SSRIs inhibitors, ranging between 0 and 2% for hydrolysis and 0 and 6% for photolysis. The biodegradation was also slow, ranging from 0 to 3% within an 8-h period. In untreated sewage, citalopram (CIT) and sertraline (SER) concentrations may be high enough to exert effects on the aquatic biota (CIT: 0.19-10.3 µg/L; SER: 0.14-17.1 µg/L). Removal of the pharmaceuticals is due primarily to sorption in the WWTP. Sertraline was estimated to have the highest concentrations in the sewage effluents, 4.4 and 19.9 ng/L for the two cases, respectively. In treated wastewater, individual SSRI concentrations are probably too low to exert effects on biota. By using concentration addition, a cocktail exposure scenario was estimated. The predicted concentration in the biota calculated from the cocktail effect was 0.05 and 0.16 nmol/g for the two cases, respectively, and SER was found to give the highest contribution to this cocktail effect. The results indicate that the concentrations in the wastewater effluents are one to two orders of magnitude lower than the concentrations likely to cause an effect in the aquatic biota.

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“…Ultrastructural re-organization involves the redistribution of microfilaments and microtubules that in turn support the relocation of cytoplasmic organelles such as cortical granules and mitochondria [Schorderet-Slatkine 1972;Masui 1985;Iwamatsu et al 1993;Voronina and Wessel 2003;Sun and Schatten 2006;Stricker 2006;Ferreira et al 2009;Liu et al 2010; De los Reyes et al 2011].…”

Section: Introductionmentioning

confidence: 99%

Ion currents modulating oocyte maturation in animals

Tosti

Boni

Gallo

et al. 2013

Systems Biology in Reproductive Medicine

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Growing oocytes are arrested at the first prophase of meiosis which is morphologically identified by the presence of a large and vesicular nucleus, called the germinal vesicle. The dissolution of the germinal vesicle marks the resumption of meiosis during which the oocyte undergoes massive modifications up to the second meiotic block, which is removed at fertilization. The interval between the first and the second meiotic block is defined as maturation and the events occurring during this period are crucial for ovulation, fertilization, and embryo development. Oocytes are excitable cells that react to stimuli by modifying their electrical properties as a consequence of ion currents flowing through ion channels on the plasma membrane. These electrical changes have been largely described at fertilization whereas little information is available during oocyte maturation. The aim of this review is to give an overview on the involvement of ion channels and ion currents during oocyte maturation in species from invertebrates to mammals. The results summarized here point to the possible functional role of ion channels underlying oocyte growth and maturation.

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Effect of 5‐Hydroxytryptamine on Steroidogenesis and Oocyte Maturation in Pre‐ovulatory Follicles of the Medaka Oryzias latipes

Cited by 36 publications

References 18 publications

Physiological Endpoints for Potential SSRI Interactions in Fish

Physiological Endpoints for Potential SSRI Interactions in Fish

Environmental risk assessment of three selective serotonin reuptake inhibitors in the aquatic environment: A case study including a cocktail scenario

Ion currents modulating oocyte maturation in animals

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