Effect of 5-S-GAD on UV-B-induced cataracts in rats

Abstract

5-S-GAD eyedrop application may delay the progression of UV-B-induced cataract in rats.

Anti-UVC Irradiation and Metal Chelation Properties of 6-Benzoyl-5,7-dihydroxy-4-phenyl-chromen-2-one: An Implications for Anti-Cataract Agent

“…Previously, UVC irradiation to induce turbidity of γ-crystallin was applied to measure the chaperone activity of lens γ-crystallin [24,25]. Lens γ-crystallin was correlated to cataracts and demonstrated in a mouse model [37].…”

“…Eye drops containing antioxidants such as tropicamide, phenylephrine, flurbiprofen, and tobramycin are also given preoperatively [24]. In recent years, the protective effects of compounds against UV-induced oxidative damage of the eye were investigated [3,25,26]. It was shown that UV irradiation can cause turbidity of γ-crystallin [27,28].…”

Effect of Astaxanthin on Cataract Formation Induced by Glucocorticoids in the Chick Embryo

“…40 In our experiments, AST was administered to chicken eggs weighing about 60 g at the maximum dose of 100 mg, i.e. at a relatively high dose of 1.67 mg/kg.…”

Insect natural products and processes: New treatments for human disease

“…Subsequently, 5-S-GAD has been shown to have multiple activities including inhibition of some cancer cells in vitro and of angiogenesis in mice sarcoma cells in vivo, as well as protecting rat retinal ganglion cells against apoptosis induced by oxygen radicals and other conditions associated with glaucoma (Koriyama et al, 2009). Even more fascinating is that 5-S-GAD prevents cataract formation in the eye (Akiyama et al, 2009), so that it has potential as a pharmaceutical drug for use in eye drops (Kawada et al, 2009).…”