Effect of 6 weeks Pilates training along with dill supplementation on serum concentrations of nesfatin-1, lipocalin-2, and insulin resistance in females with overweight and obesity

Abstract

Background: This study aimed to investigate the effect of 6 weeks’ pilates training along with dill supplementation on serum concentrations of nesfatin-1, lipocaline-2, and insulin resistance in females with overweight and obesity. Materials and Methods: In this randomized controlled trial study, 45 overweight and obese females are randomly assigned to four groups: Pilates training + dill group (PDG) ( n = 12), pilates training + placebo group (PPG) ( n = 11), dill supplementation group (DG) ( n = 11), and placebo group (PG) ( n = 11). Participants of PDG and PPG performed pilates training for 6 weeks (60 min, 3 sessions per week). PDG and DG received dill tablet (three times a day, 6 weeks). Anthropometric measurements, glycemic markers, and blood samples were assessed before (pretest) and after (posttest) 6 weeks of intervention. Results: Results showed a significant increase in serum concentrations of nesfatin-1 in PDG compared to pretest ( P = 0.001). Differences in the serum concentrations of nesfatin-1 in PDG were greater than PPG, DG, and PG ( P = 0.01). Furthermore, results found in significant reduction in serum concentrations of lipocalin-2, body mass index (BMI), and waist-hip ratio (WHR) in PDG, PPG, and DG as compared to pretest ( P > 0.05). Fasting glucose plasma (FGP) was significantly decreased in all three intervention groups PDG ( P < 0.001), PPG ( P < 0.001), and DG ( P < 0.001) as compared to pretest. Differences in FGP were significantly higher in PDG than PPG, DG, and PG ( P = 0.001). A significant reduction was found for insulin only in PDG after 6 weeks of intervention as compared to pretest ( P = 0.03). Insulin resistance significantly decreased in PDG ( P = 0.03) and PPG ( P = 0.04) as compared to pretest. Body fat percent (BFP) was significantly decreased in PDG ( P = 0.003), PPG ( P = 0.006), and DG ( P = 0.01). However, there were no significant inter-group differences in insulin resistance, insulin, serum concentrations of lipocalin-2, BMI, BFP, and WHR after 6 weeks of Pilates training along with dill supplementation ( P > 0.05). Conclusion: We concluded that 6 weeks of Pilates training along with dill may be beneficial for improvements in serum concentrations of nesfatin-1 and FGP.

Effects of physical activity and exercise on Nucleobindin‐2 gene expression and Nesfatin‐1 concentration: A rapid review

“…In a randomized controlled trial (RCT) study on females living with overweight and obesity, Sabzevari et al investigated the effect of 6 weeks’ Pilates training (60 min, 3 sessions per week) on serum Nesfatin‐1 concentrations. Pilates training had no significant effect on serum Nesfatin‐1 concentration 51 …”

“…From the 36 included studies, 23 examined humans 41–63 with 13 examining animal models 64–76 . Studies investigated the effects of chronic exercise training 41–51,63 and acute exercise 48,52–62 in humans. One study compared the effect of chronic and acute exercise 48 .…”

“…The purpose of conducting this review is to assess the existing research evidence regarding the impact of exercise on Nucleobindin-2 (NUCB2) gene expression and Nesfatin-From the 36 included studies, 23 examined humans with 13 examining animal models. [64][65][66][67][68][69][70][71][72][73][74][75][76] Studies investigated the effects of chronic exercise training [41][42][43][44][45][46][47][48][49][50][51]63 and acute exercise 48,[52][53][54][55][56][57][58][59][60][61][62] in humans.…”

“…Several studies have investigated the effect of endurance exercise training on Nesfatin-1 concentration in humans. 41,46,48,50,51,63 Ahmadizad et al investigated the effects of 6 weeks of highintensity interval training (HIIT: 3 days per week for 6 weeks) and moderate-intensity continuous exercise training (MICT: 3 days per week for 6 weeks) followed by a week of detraining on plasma Nesfatin-1 of physically inactive overweight men. They showed that plasma Nesfatin-1 only increased as a result of HIIT.…”

“…In the HIIT group, plasma Nesfatin-1 did not return to pre-training concentration following a detraining period. 41 51 Arıkan investigated the effects of 8 weeks of cycling exercises (40-60 min/session, 3 days/week for at 60%-80% of maximal heart rate) on plasma Nesfatin-1 concentration in young adult male F I G U R E 1 PRISMA flow diagram highlighting the outcome of screening. 40 university students.…”