Effect of a calcium hydroxide/chlorhexidine paste as intracanal dressing in human primary teeth with necrotic pulp against <i>Porphyromonas gingivalis</i> and <i>Enterococcus faecalis</i>

Gondim, Juliana Oliveira; Avaca-Crusca, Juliana Sposto; Valentini, Sandro Roberto; Zanelli, Cleslei Fernando; Spolidório, Denise Madalena Palomari; Giro, Elisa María Aparecida

doi:10.1111/j.1365-263x.2011.01174.x

Cited by 33 publications

(38 citation statements)

References 26 publications

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“…This study revealed that calcium hydroxide, pure or associated with chlorhexidine and 20% glycolic ginger extract, was effective on the micro-organisms tested. The antimicrobial action of Ca(OH) 2 has been demonstrated in other studies [9,21]. Even though reports demonstrate that Ca(OH) 2 is not effective on Enterococcus faecalis [22], it presented 100% effectiveness in this study.…”

Section: Discussioncontrasting

confidence: 69%

In vitroantimicrobial and anti-endotoxin action ofZingiber Officinaleas auxiliary chemical and medicament combined to calcium hydroxide and chlorhexidine

Valera

Cardoso

Maekawa

et al. 2015

Acta Odontologica Scandinavica

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Section: Discussioncontrasting

confidence: 69%

In vitroantimicrobial and anti-endotoxin action ofZingiber Officinaleas auxiliary chemical and medicament combined to calcium hydroxide and chlorhexidine

Valera

Cardoso

Maekawa

et al. 2015

Acta Odontologica Scandinavica

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“…The fnal results of the search in Medline (via PubMed), EMbase, EBSCOhost, The Cochrane Library, SciELO, and BBO were 77, 65, 17, 3, 4, and 7 studies, respectively. After the primary review, 44 studies 2-8,14-16,20,22,26-30,35,40,50,52,55-57,62-64,67,68,71,72,80,85,89,95,97,98,102,104,105,107,113-115 were considered relevant, and 40 studies 1,9,10,13,19,24,25,31,34,38,42-44,46-49,51,53,54,58-60,65,66,69,75-79,81,83,86,94,103,106,110-112 were irrelevant. Inter-observer agreement (Cohen kappa) was 0.93.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial effect of calcium hydroxide combined with chlorhexidine on Enterococcus faecalis: a systematic review and meta-analysis

et al. 2014

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ObjectiveEnterococcus faecalis (E. faecalis) is the most frequently isolated strain in failed endodontic therapy cases since it is resistant to calcium hydroxide (CH). Whether a combination of CH and chlorhexidine (CHX) is more effective than CH alone against E. faecalis is a matter of controversy. Thus, the aim of this study was to conduct a systematic review and meta-analysis of the literature.Material and MethodsA comprehensive search in PubMed, EMbase, EBSCOhost, The Cochrane Library, SciELO, and BBO databases, Clinical trials registers, Open Grey, and conference proceedings from the earliest available date to February 1, 2013 was carried out and the relevant articles were identified by two independent reviewers. Backward and forward search was performed and then inclusion and exclusion criteria were applied. The included studies were divided into "comparisons" according to the depth of sampling and dressing period of each medicament. Meta-analysis was performed using Stata software 10.0. The level of significance was set at 0.05.ResultsEighty-five studies were retrieved from databases and backward/forward searches. Fortyfive studies were considered as relevant (5 in vivo, 18 in vitro, 18 ex vivo, and 4 review articles). Nine studies were included for meta-analysis. Inter-observer agreement (Cohen kappa) was 0.93. The included studies were divided into 21 comparisons for meta-analysis. Chi-square test showed the comparisons were heterogeneous (p<0.001). Random effect model demonstrated no significant difference between CH/CHX mixture and CH alone in their effect on E. faecalis (p=0.115).ConclusionsAccording to the evidence available now, mixing CH with CHX does not significantly increase the antimicrobial activity of CH against E. faecalis. It appears that mixing CH with CHX does not improve its ex vivo antibacterial property as an intracanal medicament against E. faecalis. Further in vivo studies are necessary to confirm and correlate the findings of this study with the clinical outcomes.

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“…Studies on the efficacy of lasers in endodontic therapy have mostly focused on permanent teeth [10], while studies on primary teeth have been rarely reported. Meanwhile, because of the complicated anatomical structure of the pulpal chamber [11], choosing the most effective disinfection protocol for pulp-infected primary teeth becomes particularly important.…”

Section: Introductionmentioning

confidence: 99%

Bactericidal effect of a diode laser on Enterococcus faecalis in human primary teeth—an in vitro study

et al. 2018

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BackgroundIn recent years, the diode laser (810 nm) has been used for root canal disinfection, which plays an important role in endodontic therapy. This study was undertaken to evaluate the disinfecting ability of a diode laser in experimentally infected root canals of primary teeth.MethodsHuman retained mandibular primary anterior teeth without apical foramen resorption were selected and contaminated with Enterococcus faecalis for 21 days. The specimens were randomly divided into four groups: the negative group (no treatment), positive group (5.25% NaOCl), diode laser group (diode laser), and diode-NaOCl group (diode laser combined with NaOCl). The disinfecting abilities of the treatments were measured by the numbers of bacteria, scanning electron microscopy and confocal laser microscopy (live-dead staining).ResultsEighty teeth were selected. After irradiation and irrigation, the elimination of bacteria and the smear layer in the laser groups and positive group were significantly superior, compared with the negative group (p < 0.01). In the diode-NaOCl group, bacterial reduction reached nearly 100% on the surfaces of root canals; live bacteria were rarely observed, even in deeper dentinal tubules.ConclusionUse of a diode laser, especially in combination with NaOCl, was effective for disinfecting infected root canals of primary teeth.

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Effect of a calcium hydroxide/chlorhexidine paste as intracanal dressing in human primary teeth with necrotic pulp against Porphyromonas gingivalis and Enterococcus faecalis

Abstract: The association of chlorhexidine with calcium hydroxide did not increase the antibacterial activity of the intracanal medication in the treatment of primary teeth with necrotic pulp with and without furcal/periapical lesion.

Cited by 33 publications

References 26 publications

In vitroantimicrobial and anti-endotoxin action ofZingiber Officinaleas auxiliary chemical and medicament combined to calcium hydroxide and chlorhexidine

In vitroantimicrobial and anti-endotoxin action ofZingiber Officinaleas auxiliary chemical and medicament combined to calcium hydroxide and chlorhexidine

Antibacterial effect of calcium hydroxide combined with chlorhexidine on Enterococcus faecalis: a systematic review and meta-analysis

Bactericidal effect of a diode laser on Enterococcus faecalis in human primary teeth—an in vitro study

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