Effect of a carotenoid-producing Bacillus strain on intestinal barrier integrity and systemic delivery of carotenoids: A randomised trial in animals and humans

Stevens, Yala; Pinheiro, Iris; Salden, Bouke; Duysburgh, Cindy; Bolca, Selin; Degroote, Jeroen; Majdeddin, Maryam; Noten, Noémie Van; Gleize, Béatrice; Caris-Veyrat, Catherine; Michiels, Joris; Jonkers, Daisy; Troost, Freddy J.; Possemiers, Sam; Masclee, Ad

doi:10.1016/j.jff.2021.104445

Cited by 8 publications

(23 citation statements)

References 38 publications

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“…Another example comes from a recent study in which a carotenoid-producing strain of B. indicus was shown to deliver its carotenoid to the human body causing an increased systemic carotenoid accumulation and improving the barrier functions [58]. In this study, over 60 healthy overweight or obese volunteers showed increased concentrations of bacterial carotenoid in plasma samples after three and six weeks of daily supplementation of the carotenoid-producing probiotic [58].…”

Section: Bacillus Probiotics For Human Usementioning

confidence: 73%

Spore Formers as Beneficial Microbes for Humans and Animals

Saggese

Baccigalupi

Ricca

2021

Applied Microbiology

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Microorganisms efficiently colonize the external and internal surfaces of the animal body establishing mutually beneficial interactions and forming site- and individual-specific microbiota. The degradation of complex polysaccharides in the animal gut, the production of useful compounds, protection against pathogenic microorganisms and contribution to the development of an efficient immune system are the main beneficial effects of a balanced microbiota. A dysbiosis, an imbalanced composition of the microbiota, has been associated with a large number of diseases from gastro-intestinal or urogenital disorders to allergies, cardiovascular and autoimmune diseases and even to the onset of certain cancers. A growing body of evidence has indicated that probiotic treatments, aimed at maintaining or rebalancing the microbiota, are useful to treat/prevent those illnesses. Lactic Acid Bacteria and Bifidobacteria are the most common microbes used in probiotic preparations; however, other bacteria and yeast cells are also widely used in commercial products. Here we focus on the use of bacterial spore formers as probiotics. Spore formers have been marketed as probiotics for over 50 years and are now extensively used for the treatment of intestinal disorders and as dietary supplements in humans, as growth promoters and competitive exclusion agents in animals.

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Section: Bacillus Probiotics For Human Usementioning

confidence: 73%

Spore Formers as Beneficial Microbes for Humans and Animals

Saggese

Baccigalupi

Ricca

2021

Applied Microbiology

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“…The prepared intestinal segments and intestinal mucosa of the test animals in each group were fixed in the diffusion chamber; the mucosal side was washed with Ringer’s solution (pH = 7.3) ( Li et al, 2021 ; Stevens et al, 2021 ), and the biological activity of the intestinal mucosa was maintained at a constant temperature of 37.5°C for 30 min. Transepithelial resistance was calculated after the equilibration period, and TER (Ω cm 2 ) was recorded every 15 min for 1 h. Data were averaged to calculate the TER value for each rat.…”

Section: Methodsmentioning

confidence: 99%

Preventive effects of the Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple on chronic kidney disease rats via modulating the intestinal microbiota and enhancing the intestinal barrier

et al. 2022

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CKD is a clinical syndrome with slow development and gradual deterioration of renal function. At present, modern medicine still lacks an ideal treatment method for this disease, while TCM has accumulated rich clinical experience in the treatment of CKD, which can effectively improve renal function and delay renal failure, and has unique advantages. RC is widely used in clinical practice to treat CKD, especially the “Kidney-Yin” deficiency syndrome. However, the compatibility mechanisms responsible for its effects in experimental studies, including preclinical and clinical research studies, are still not fully understood. Adenine-induced CKD rats were used to investigate the preventive effect of RC on CKD rats. Based on the high-throughput 16S rRNA gene sequencing results from Illumina, we discussed the intestinal flora abundance in rats in different treatment groups. According to a PCA and a PCoA based on a distance matrix, there was a clear separation of gut microbiome profiles between normal rats and model rats in terms of beta diversity. The abundance of Firmicutes in CKD rats was relatively increased, while that of Bacteroidetes was decreased. It is clear that the plot for the RC group was closer to that of the normal group, suggesting that the RC group had higher similarities among bacterial members with N rats. Ussing chamber, Western blot, and PCR assays were used to investigate the effects of RC on intestinal barrier function and its molecular mechanism in model animals. The results indicated that the protein expressions of ZO-1, claudin-1, and occludin-1 were decreased significantly in chronic kidney disease rats with the induction of adenine. With the treatment of RG, CO, and RC, the intestinal barrier was repaired due to the upregulated expressions of the aforementioned proteins in CKD rats. Based on our findings, RC appears to strengthen the intestinal barrier and modulate gut microbiota in adenine-induced CKD rats. This project revealed the compatibility mechanism of RC in regulating the intestinal microecology and barrier function to intervene in CKD and provided the basis and ideas for the clinical application of RC and the development of innovative drugs for CKD.

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“…It is well recognized that increasing the propionate-to-acetate ratio promotes a decrease in methane synthesis, which reduces the availability of hydrogen to Archaea and so avoids the formation of gut dysbiosis [ 220 ]. The study also shows that carotenoids protect the mucosa and epithelial gut barrier, as well as tight junction integrity [ 221 ]. Additionally, there is evidence that fucoxanthin, a marine carotenoid, affects the regulation of the intestinal microbiota and especially plays a key role in promoting the growth of Akkermansia muciniphila , which can repair intestinal mucosa through immune modulation [ 222 , 223 , 224 ].…”

Section: Dietary Carotenoids In Depressionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Effects of Carotenoids in Mood Disorders: An Overview

Rasmus

Kozłowska

2023

Antioxidants

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Depression has a multifactorial etiology comprising family history and unemployment. This review aims to summarize the evidence available for the antioxidant and anti-inflammatory effects of carotenoids in mood disorders. This review article’s methodologies were based on a search of the PubMed database for all linked published papers. Epidemiological studies indicate that a diet rich in vegetables, fruits, nuts, fish, and olive oil may prevent the development of depression. Antioxidant supplementation has been found to combat various stress-induced psychiatric disorders, including depression and anxiety. A growing body of evidence indicates that carotenoids have both antioxidant and anti-inflammatory. Studies also suggest that poor dietary intake, particularly low intakes of fruit and vegetables and high intakes of fast food and other convenience foods, may increase the risk of developing depression. Thus, dietary interventions have the potential to help mitigate the risk of mental health decline in both the general population and those with mood disorders. Considering that carotenoids have both antioxidant and anti-inflammatory effects, it is expected that they might exert a promising antidepressant effect. Nevertheless, further studies (including interventional and mechanistic studies) assessing the effect of carotenoids on preventing and alleviating depression symptoms are needed.

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Effect of a carotenoid-producing Bacillus strain on intestinal barrier integrity and systemic delivery of carotenoids: A randomised trial in animals and humans

Cited by 8 publications

References 38 publications

Spore Formers as Beneficial Microbes for Humans and Animals

Spore Formers as Beneficial Microbes for Humans and Animals

Preventive effects of the Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple on chronic kidney disease rats via modulating the intestinal microbiota and enhancing the intestinal barrier

Antioxidant and Anti-Inflammatory Effects of Carotenoids in Mood Disorders: An Overview

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