Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind study

Verhoeven, Marieke O.; Mooren, M.J. van der; Weijer, P. H. M. van de; Verdegem, P. J. E.; Burgt, Leontine M. J. Van Der; Kenemans, P.

doi:10.1097/01.gme.0000170603.63022.62

Cited by 58 publications

(25 citation statements)

References 28 publications

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“…The topic has been adequately reviewed and overall evidence shows that phytoestrogen extracts of soy and red clover have little or no effect; at best only 10% reduction of symptoms beyond that of the placebo effect (Kurzer 2003, Geller & Studee 2005. Some studies have shown that black cohosh reduced symptoms, primarily hot flushes and mood disorders (Geller & Studee 2005, Viereck et al 2005, but recent studies have shown no significant effects of this extract on hot flushes (Newton et al 2005, Verhoeven et al 2005.…”

Section: Efficacy Of Phytoestrogens As Alternatives To Hrtmentioning

confidence: 99%

Phytoestrogens and breast cancer –promoters or protectors?

Rice¹,

Whitehead²

2006

Endocr Relat Cancer

165

119

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The majority of breast cancers are oestrogen dependent and in postmenopausal women the supply of oestrogens in breast tissue is derived from the peripheral conversion of circulating androgens. There is, however, a paradox concerning the epidemiology of breast cancer and the dietary intake of phytoestrogens that bind weakly to oestrogen receptors and initiate oestrogendependent transcription. In Eastern countries, such as Japan, the incidence of breast cancer is approximately one-third that of Western countries whilst their high dietary intake of phytoestrogens, mainly in the form of soy products, can produce circulating levels of phytoestrogens that are known experimentally to have oestrogenic effects. Indeed, their weak oestrogenicity has been used to advantage by herbalist medicine to promote soy products as a natural alternative to conventional hormone replacement therapy (HRT). Such usage could increase in light of recent evidence that long-term HRT usage may be associated with an increased risk of breast cancer with a consequent reduction in prescription rates. So, are phytoestrogens safe as a natural alternative to HRT and could they be promoters or protectors of breast cancer? If they are promoters, then we must assume that it is due to their oestrogenic effect. If they are protectors, then other actions of phytoestrogens, including their ability to inhibit enzymes that are responsible for converting androgens and weak oestrogens into oestradiol, must be considered. This paper addresses these questions by reviewing the actions of phytoestrogens on oestrogen receptors and key enzymes that convert androgens to oestrogens in relation to the growth of breast cancer cells. In addition, it compares the experimental and epidemiological evidence pertinent to the potential beneficial or harmful effects of phytoestrogens in relation to the incidence/progression of breast cancer and their efficacy as natural alternatives to conventional HRT.

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Section: Efficacy Of Phytoestrogens As Alternatives To Hrtmentioning

confidence: 99%

Phytoestrogens and breast cancer –promoters or protectors?

Rice¹,

Whitehead²

2006

Endocr Relat Cancer

165

119

View full text Add to dashboard Cite

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“…Os extratos dessa planta f oram usados historicamente como antiinflamatórios, antipiréticos e analgésicos dentre outras indicações, como no tratamento das cólicas menstruais e nos sintomas da menopausa (Bolle et al, 2007). Recentemente passou a ser utilizado em todo mundo, mas principalmente nos Estados Unidos e na Europa, por mulheres para aliviar os sintomas do climatério (Vermes et al, 2005).…”

Section: Atividades Farmacológicas Evidenciadasunclassified

“…Entre as principais ações estão a diminuição intensa dos fogachos (Mahady et al, 2002;Vermes et al, 2005); a diminuição da ansiedade, depressão, cefaléia, distúrbios do sono e vertigens (Borreli & Ernst, 2002;Vermes et al, 2005) e a melhora acentuada da atrofia vaginal (Wuttke et al, 2003b).…”

Section: Atividades Farmacológicas Evidenciadasunclassified

“…A eficiência tem sido por vezes questionada, demandando constantes trabalhos experimentais e de revisão sobre as evidências terapêuticas disponíveis (Borrelli & Ernst, 2002). Há inclusive ensaios clínicos multicêntricos controlados por placebo, nos quais C. racemosa não apresentou nenhum efeito significativo na melhora dos sintomas climatéricos da perimenopausa (Verhoeven et al, 2005).…”

Section: Introductionunclassified

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Avanços na elucidação dos mecanismos de ação de Cimicifuga racemosa (L.) Nutt. nos sintomas do climatério

Silva

Brandão

Cacciari

et al. 2009

Rev. bras. plantas med.

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RESUMO:O objetivo deste trabalho foi levantar os avanços ocorridos para a compreensão da atuação terapêutica de Cimicifuga racemosa, um fitoterápico utilizado no tratamento dos sintomas do climatério em mulheres nas quais a terapia de reposição hormonal (TRH) é contra-indicada. A revisão bibliográfica possibilitou concluir que existem quatro principais hipóteses para esclarecer a base mecanística de ação: indução de apoptose por meio da ativação de caspases, inibição do ciclo celular em G1 por alteração de proteínas reguladoras, efeito central em receptor 5HT e ação estrogênica evidenciada pela inibição seletiva dos receptores nicotínicos da acetilcolina. Porém, é incipiente a produção científica abordando as bases moleculares que sustentem os referidos mecanismos de ação. Ainda há necessidade de elucidação quanto à possível existência de pelo menos mais um receptor estrogênico que possa ser o alvo de ligação para as substâncias ativas de C. racemosa, bem como avançar no conhecimento da atividade reguladora seletiva de receptores estrogênicos já evidenciada em estudos de farmacologia experimental.Palavras-chave: menopausa, mecanismo de ação, terpenóides, compostos fenólicos, Cimicifuga racemosa ABSTRACT: Advances on the elucidation of mechanisms of action of Cimicifuga racemosa (L.) Nutt. in climacteric symptoms. The aim of this survey was to assemble the advances in the comprehension of the therapeutic action of Cimicifuga racemosa, a phytotherapic drug used in the treatment of climacteric symptoms in women to whom the usual hormonal replacement therapy (HRT) is counter-indicated. This literature review led to the conclusion that there are four main hypotheses to elucidate the mechanistic basis of action: apoptosis induction by means of caspase activation, cell cycle inhibition at G1 step through disturbance of regulatory proteins, central effect on 5HT receptors, and estrogenic action evidenced by selective inhibition of nicotinic acetylcholine receptors. However, scientific literature is still incipient in supporting the molecular bases for the previously proposed mechanisms of action. There is also the need to elucidate a probable new estrogen receptor that might be the target for active substances from C. racemosa, as well as to advance on the knowledge of the selective modulation of estrogen receptors, which has already been evidenced by experimental pharmacology.

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“…Até o momento, não existem dados que suportem seu Rev Bras Ginecol Obstet. 2006; 28(3): 195-204 uso na prática clínica 56 . Com a finalidade de avaliar o impacto dos fitoestrogênios na QV e nos sintomas climatéricos de mulheres com câncer de mama, realizou-se estudo aleatorizado, duplo-cego, controlado com placebo.…”

Section: Síndrome Climatéricaunclassified

Qualidade de vida de mulheres com câncer de mama

Conde¹,

Pinto‐Neto²,

Júnior³

et al. 2006

Rev. Bras. Ginecol. Obstet.

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RESUMOO câncer de mama é uma das neoplasias mais comuns entre mulheres. O diagnóstico e a terapia antineoplásica determinam repercussões sociais, econômicas, físicas, emocionais/psicológicas e sexuais. Os principais parâmetros empregados na avaliação dos resultados da terapia antineoplásica são a sobrevida livre de doença e a sobrevida global. Mais recentemente, a qualidade de vida (QV) tem sido considerada mais um desses parâmetros. Não existe consenso quanto à definição de QV. Porém, a maioria das definições contempla os aspectos multidimensional e subjetivo da QV. A identificação dos fatores relacionados à QV e a compreensão da forma como esses fatores contribuem para a percepção da QV são motivos de discussão, uma vez que o conceito de QV está diretamente relacionado ao contexto sociocultural em que o indivíduo está inserido. A idade ao diagnóstico, uso de quimioterapia, tipo de cirurgia, sintomas climatéricos, relacionamento conjugal e sexualidade são alguns fatores associados à QV de mulheres com câncer de mama. A QV associada a diferentes terapias antineoplásicas pode auxiliar pacientes e médicos na escolha da melhor modalidade terapêutica. Nesse sentido, o presente artigo revisa diversos aspectos da QV de mulheres com câncer de mama, apresentando e discutindo o estado atual do conhecimento sobre o tema. PALAVRAS-CHAVE: Neoplasias mamárias; Qualidade de vida; Sintomas climatéricos ABSTRACTBreast cancer is one of the most common malignancies among women. Its diagnosis and treatment have social, economic, physical, emotional/psychological and sexual repercussions. The main parameters used to assess the results of anticancer therapy are disease-free survival and overall survival. More recently, quality of life (QOL) has been considered an additional parameter. No consensus exists about the definition of QOL. However, most definitions take into account multidimensional and subjective aspects of QOL. The identification of factors related to QOL and comprehension of how these factors contribute to the perception of QOL are reasons for debate, since the concept of QOL is directly related to the social and cultural context in which the individual is inserted. Age at diagnosis, chemotherapy, type of surgery, climacteric symptoms, relationship between the couple, and sexuality are several factors associated with QOL in women with breast cancer. QOL associated with different antineoplastic therapies may help patients and physicians choose the best therapeutic modality. Towards this end, the current article addresses various aspects of QOL of breast cancer women, and presents the state-ofthe-art knowledge on the topic. KEYWORDS:

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Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind study

Abstract: The supplement containing soy isoflavones and A racemosa L. had no statistically significant effect on climacteric symptoms in perimenopausal women experiencing at least five vasomotor symptoms per day.

Cited by 58 publications

References 28 publications

Phytoestrogens and breast cancer –promoters or protectors?

Phytoestrogens and breast cancer –promoters or protectors?

Avanços na elucidação dos mecanismos de ação de Cimicifuga racemosa (L.) Nutt. nos sintomas do climatério

Qualidade de vida de mulheres com câncer de mama

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