Effect of a combination of oral midazolam and low-dose ketamine on anxiety, pain, swelling, and comfort during and after surgical extractions of mandibular third molars

Gupta, Rubina; Sharma, Kiran; Dhiman, Umesh

doi:10.4103/0970-9290.100460

Cited by 12 publications

(16 citation statements)

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“…Contrary to these studies [32,34,36]; in our study comparison of facial measurements and mouth opening in both the groups showed overall no statistically significant difference on the 1st, 3rd and 7th post-operative days. Thus sub-mucosal infiltration of 0.5 mg/kg ketamine did not seem to be effective in reducing postoperative swelling or trismus.…”

Section: Discussioncontrasting

confidence: 99%

“…In various studies done by Satilmiş et al [32], Garip et al [33], Gupta et al [36] ketamine has shown to reduce postoperative pain and swelling in patients undergoing surgical removal of third molars and also provide a comfortable procedure for the surgeon and patient. But in contrast Lebrun et al [35] concluded that there was no benefit to pre-emptive administration of ketamine 300 lg/ kg iv whether administered pre-or postoperatively after assessing the effect on 84 patients scheduled for third molar surgical removal.…”

Section: Discussionmentioning

confidence: 98%

“…Recently ketamine has been used in oral and maxillofacial surgical practice as well [14,[32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

“…The patients received ketamine by intramuscular injection and all three forms of ketamine consistently relieved postoperative pain. Gupta et al [36] assessed the clinical efficacy of premedication with a combination of oral midazolam (0.25 mg/kg) plus lowdose ketamine (5 mg/kg) prior to surgical removal of third molars resulting in significantly low pain scores at 30 min and 24 h post operatively. Satilmiş et al [32] assessed the clinical efficacy of combined treatment with local anesthetic and sub-anesthetic ketamine (0.3 mg/kg) during surgical extraction of third molars.…”

Section: Discussionmentioning

confidence: 99%

“…Gupta et al [36] checked postoperative swelling 24 h after surgery; out of 30 patients, only 5 patients showed slight swelling when oral midazolam plus low-dose ketamine was used, whereas 12 patients showed swelling when placebo was used. Garip et al [34] found that facial swelling on postoperative days 1, 3 and 7 was significantly lower in the midazolam plus ketamine group than in midazolam plus placebo group and also mouth opening was significantly better on postoperative days 1 and 3 in the midazolam plus ketamine group.…”

Section: Discussionmentioning

confidence: 99%

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Pre-Emptive Analgesia with Ketamine for Relief of Postoperative Pain After Surgical Removal of Impacted Mandibular Third Molars

Hadhimane

Shankariah

Neswi

2015

J. Maxillofac. Oral Surg.

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Purpose In this study we assessed the clinical efficacy of sub-mucosal injection of ketamine at sub-anesthetic dose of 0.5 mg/kg on post-operative pain, swelling and trismus following surgical extraction of impacted mandibular third molars. Methods Forty bilaterally symmetrical impacted mandibular third molars in 20 patients who required surgical removal were included in the study. Within the same individual, one of the sites received a test medication whereas the other site was used as control. All patients received nerve blocks with local anesthetic (2 % lignocaine hydrochloride with 1:80,000 adrenaline); the Test group received sub-mucosal infiltration of 0.5 mg/kg of ketamine hydrochloride (without preservative) around the impacted mandibular third molar and along the incision line, while the Placebo group received normal saline infiltration, 10 min before placement of the incision. Results The pain scores on VAS at 30 min, 1, 4, 12 h and 1 day post-operatively was significantly lower in the Test group than in the Placebo group (p \ .05). With respect to facial swelling and mouth opening the Test group and Placebo group showed overall no statistically significant difference (p [ .05) on the 1st, 3rd and 7th post-operative days. Conclusion The sub-mucosal injection of 0.5 mg/kg ketamine administered before surgical removal of impacted mandibular third molars was found to be effective in significantly reducing post-operative pain for the first 24 h.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 98%

“…Recently ketamine has been used in oral and maxillofacial surgical practice as well [14,[32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Pre-Emptive Analgesia with Ketamine for Relief of Postoperative Pain After Surgical Removal of Impacted Mandibular Third Molars

Hadhimane

Shankariah

Neswi

2015

J. Maxillofac. Oral Surg.

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Does Sub-Anesthetic Ketamine Provide Postoperative Analgesia for Third Molar Surgery?

Cheung

Alashi

Koto

et al. 2019

Journal of Oral and Maxillofacial Surgery

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A novel speculum-free imaging strategy for visualization of the internal female lower reproductive system

Asiedu

Agudogo

Dotson

et al. 2020

Sci Rep

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Fear of the speculum and feelings of vulnerability during the gynecologic exams are two of the biggest barriers to cervical cancer screening for women. To address these barriers, we have developed a novel, low-cost tool called the Callascope to reimagine the gynecological exam, enabling clinician and self-imaging of the cervix without the need for a speculum. The Callascope contains a 2 megapixel camera and contrast agent spray mechanism housed within a form factor designed to eliminate the need for a speculum during contrast agent administration and image capture. Preliminary bench testing for comparison of the Callascope camera to a $20,000 high-end colposcope demonstrated that the Callascope camera meets visual requirements for cervical imaging. Bench testing of the spray mechanism demonstrates that the contrast agent delivery enables satisfactory administration and cervix coverage. Clinical studies performed at Duke University Medical Center, Durham, USA and in Greater Accra Regional Hospital, Accra, Ghana assessed (1) the Callascope’s ability to visualize the cervix compared to the standard-of-care speculum exam, (2) the feasibility and willingness of women to use the Callascope for self-exams, and (3) the feasibility and willingness of clinicians and their patients to use the Callascope for clinician-based examinations. Cervix visualization was comparable between the Callascope and speculum (83% or 44/53 women vs. 100%) when performed by a clinician. Visualization was achieved in 95% (21/22) of women who used the Callascope for self-imaging. Post-exam surveys indicated that participants preferred the Callascope to a speculum-based exam. Our results indicate the Callascope is a viable option for clinician-based and self-exam speculum-free cervical imaging. Clinical study registration ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/record/ NCT00900575, Pan African Clinical Trial Registry (PACTR) https://www.pactr.org/ PACTR201905806116817.

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Effect of a combination of oral midazolam and low-dose ketamine on anxiety, pain, swelling, and comfort during and after surgical extractions of mandibular third molars

Abstract: Premedication with midazolam plus low-dose ketamine prior to surgical extraction of third molars can provide the patient with a comfortable procedure and good postoperative analgesia, with less swelling and significantly less pain.

Cited by 12 publications

References 0 publications

Pre-Emptive Analgesia with Ketamine for Relief of Postoperative Pain After Surgical Removal of Impacted Mandibular Third Molars

Pre-Emptive Analgesia with Ketamine for Relief of Postoperative Pain After Surgical Removal of Impacted Mandibular Third Molars

Does Sub-Anesthetic Ketamine Provide Postoperative Analgesia for Third Molar Surgery?

A novel speculum-free imaging strategy for visualization of the internal female lower reproductive system

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