Effect of a conjugated oestrogen (Premarin®) cream on ageing facial skin. a Comparative study with a placebo cream

Creidi, P.; Faivre, B.; Agache, P; Richard, Elisabeth G.; Haudiquet, V.; Sauvanet, J.-P.

doi:10.1016/0378-5122(94)90074-4

Cited by 111 publications

(55 citation statements)

References 13 publications

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“…Creidi et al, 68 in a randomized, double-blind, placebocontrolled study of 54 women, reported an improvement in fine wrinkling assessed by clinical examination after 24 weeks of therapy with Premarin cream applied to the face at bedtime. However, patient self-assessments did not reflect any changes from baseline in perception of facial appearance including wrinkling.…”

Section: Aging: Skin Laxity and Wrinklingmentioning

confidence: 97%

Estrogen and skin: The effects of estrogen, menopause, and hormone replacement therapy on the skin

Hall¹,

Phillips²

2005

Journal of the American Academy of Dermatology

276

193

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Section: Aging: Skin Laxity and Wrinklingmentioning

confidence: 97%

Estrogen and skin: The effects of estrogen, menopause, and hormone replacement therapy on the skin

Hall¹,

Phillips²

2005

Journal of the American Academy of Dermatology

276

193

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“…-30% in den ersten 4 Jahren der Menopause, anschließend 2,1%/Jahr) [52]. Die erste National Health and Nutrition Examination Survey (NHAMES), die bei 3.875 menopausalen Frauen im Durchschnittsalter von 61 Jahren durchgeführt wurde,hat gezeigt,dass die Östrogensub-stitution zu einer signifikanten Abnahme der Hautxerose bei weißen Frauen (83% des untersuchten Kollektivs; Odds-Ratio 0,68) und zu einer Abnahme der Hautfalten beim gesamten Kollektiv (Odds-Ratio von 0,68) geführt hat [17].Eine Zunahme der Hautdicke durch eine systemische Östrogensubstitution wurde auch durch weitere Untersuchungen nachgewiesen [8,37,51].Darüber hinaus nahm durch eine lokale Östrogenapplikation die Hautdicke zu [9,11,14,59]. Interessanterweise blieb durch eine Östrogensubstitution der dermale Kollagengehalt menopausaler Frauen erhalten, wenn diese Frauen seit dem Anfang ihrer Menopause mit Östro-genen substituiert wurden [10].…”

Section: Reduzierte Fibroblastenzahlunclassified

Intrinsische Hautalterung

Zouboulis

2003

Der Hautarzt

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Intrinsic skin aging is determined primarily by genetic factors and hormonal status. It reflects the same degenerative process seen in other organs. Skin function is one of the parameters most influenced by aging. The hormonal influences include reduced pituitary, adrenal and gonadal secretion. The hormonal changes of aging lead to the development of a specific body and skin phenotype. Individuals in developed lands spend up to a third of their life (women-post-menopausal) or perhaps 20 years (men-partial androgen deficiency of the aging man, PADAM) with oestrogen or androgen deficiency. Other hormones whose levels decrease with aging include melatonin, growth hormone (GH), dehydroepiandrosterone und insulin-like growth factor-I (IGF-I). Since the skin not only fulfils a protective function for the organism but is also an active peripheral endocrine organ, which even releases effective hormones in the circulation, local hormone substitution could become interesting in the future.

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“…Topical estradiol (17␤-estradiol) induces procollagen in abdominal skin of postmenopausal women (38% increase in total collagen 32 and hydroxyproline 31 content in estradioltreated skin after 3 months) and hip skin of elderly men and women (58% increase in procollagen after the use of estradiol cream, 0.01%, twice a week for 2 weeks). 33 When applied to the photoaged face, estrogens increase skin thickness (7.8% increase vs placebo), 34 increase epidermal thickness, 35 and decrease fine wrinkles 34 but have no effect on epidermal hydration. 36 To our knowledge, the effects of topical estrogens on procollagen production in photoaged skin have not been reported.…”

mentioning

confidence: 99%

Induction of Collagen by Estradiol

Rittié¹,

Kang²,

Voorhees³

et al. 2008

Arch Dermatol

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To evaluate the effectiveness of topical estradiol in stimulating collagen I and III production in naturally aged and photoaged human skin of postmenopausal women and age-matched men.Design: Vehicle-controlled treatment followed by biochemical and immunohistochemical analyses of skin biopsy specimens.Setting: Academic referral center.Participants: Seventy healthy volunteers (40 postmenopausal women with a mean age of 75 years, and 30 men with a mean age of 75 years) with photodamaged skin.Interventions: Topical application of estradiol, 0.01%, 0.1%, 1%, or 2.5% or vehicle on aged or photoaged skin, with biopsy specimens taken after last treatment.Main Outcome Measures: De novo synthesis of collagen by quantitative polymerase chain reaction, immunohistochemistry, and enzyme-linked immunosorbent assay.Results: Topical estradiol increased procollagen I and III messenger RNA and collagen I protein levels in sun-protected aged hip skin in postmenopausal women and, to a lesser extent, in age-matched men. Surprisingly, no significant changes in production were observed in women or men after 2-week estradiol treatment of photoaged forearm or face skin, despite similar expression of estrogen receptors (ER-␣, ER-␤, and GPR30) in aged and photoaged skin. Estradiol treatment induced the estrogenresponsive gene GREB1, indicating that penetration of topical estradiol and genomic response to estrogen were similar in the 3 anatomic sites.Conclusions: Two-week topical estradiol treatment stimulates collagen production in sun-protected hip skin, but not in photoaged forearm or face skin, in postmenopausal women and aged-matched men. These findings suggest that menopause-associated estrogen decline is involved in reduced collagen production in sun-protected skin. Interestingly, alterations induced by long-term sun exposure hinder the ability of topical 2-week estradiol to stimulate collagen production in aged skin.

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Effect of a conjugated oestrogen (Premarin®) cream on ageing facial skin. a Comparative study with a placebo cream

Cited by 111 publications

References 13 publications

Estrogen and skin: The effects of estrogen, menopause, and hormone replacement therapy on the skin

Estrogen and skin: The effects of estrogen, menopause, and hormone replacement therapy on the skin

Intrinsische Hautalterung

Induction of Collagen by Estradiol

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