Effect of a denture base acrylic resin containing silver nanoparticles on<i>Candida albicans</i>adhesion and biofilm formation

Li, Zhe; Sun, Jing; Lan, Jing; Qi, Qing-guo

doi:10.1111/ger.12142

Cited by 96 publications

(78 citation statements)

References 35 publications

(56 reference statements)

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“…Some efforts have currently been made to modify the chemical composition of materials or to produce a hydrophilic layer on its surface aimed at disrupting biofilm formation (Cierech and Mierzwińska-Nastalska, 2014). A growing number of intensive studies have also been carried out to modify the chemical composition of PMMA by nanoparticles, e.g., nano-Ag (Li et al 2016) or nano-Pt (Nam, 2014). 4 Nanotechnology is one of the fastest growing areas in science and technology.…”

Section: Introductionmentioning

confidence: 99%

Significance of polymethylmethacrylate (PMMA) modification by zinc oxide nanoparticles for fungal biofilm formation

Cierech

Kolenda

Grudniak

et al. 2016

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Significance of polymethylmethacrylate (PMMA) modification by zinc oxide nanoparticles for fungal biofilm formation

Cierech

Kolenda

Grudniak

et al. 2016

International Journal of Pharmaceutics

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“…64 It was found that PMMA/BaTiO 3 composite is thermally stable, but its increased density affects denture retention. 59,65 Noble metals Silver (Ag) Several studies found that addition of silver NPs (AgNPs) to denture base acrylic resin displayed antifungal properties, [66][67][68][69] especially at high concentrations, 70 and acted like a latent antifungal material with low-releasing Ag + . 71 On the contrary, Wady et al 72 found that incorporating silver NPs in PMMA did not affect the adhesion of C. albicans and biofilm accumulation.…”

mentioning

confidence: 99%

PMMA denture base material enhancement: a review of fiber, filler, and nanofiller addition

Gad

Fouda

Al‐Harbi

et al. 2017

IJN

323

319

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This paper reviews acrylic denture base resin enhancement during the past few decades. Specific attention is given to the effect of fiber, filler, and nanofiller addition on poly(methyl methacrylate) (PMMA) properties. The review is based on scientific reviews, papers, and abstracts, as well as studies concerning the effect of additives, fibers, fillers, and reinforcement materials on PMMA, published between 1974 and 2016. Many studies have reported improvement of PMMA denture base material with the addition of fillers, fibers, nanofiller, and hybrid reinforcement. However, most of the studies were limited to in vitro investigations without bioactivity and clinical implications. Considering the findings of the review, there is no ideal denture base material, but the properties of PMMA could be improved with some modifications, especially with silanized nanoparticle addition and a hybrid reinforcement system.

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“…Furthermore, silver nanoparticles interact with the exposed sulfhydryl groups in bacterial proteins, thus preventing DNA replication 14 . Therefore, many studies have incorporated silver nanoparticles into denture base resins to prevent denture stomatitis 15, 16 or into dental resins to diminish biofilm accumulation over the composite and in the restoration margins 17–19 .…”

Section: Introductionmentioning

confidence: 99%

The antifungal effects and mechanical properties of silver bromide/cationic polymer nano-composite-modified Poly-methyl methacrylate-based dental resin

Zhang

Chen

Huang

et al. 2017

Sci Rep

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Poly-methyl methacrylate (PMMA)-based dental resins with strong and long-lasting antifungal properties are critical for the prevention of denture stomatitis. This study evaluated the antifungal effects on Candida albicans ATCC90028, the cytotoxicity toward human dental pulp cells (HDPCs), and the mechanical properties of a silver bromide/cationic polymer nano-composite (AgBr/NPVP)-modified PMMA-based dental resin. AgBr/NPVP was added to the PMMA resin at 0.1, 0.2, and 0.3 wt%, and PMMA resin without AgBr/NPVP served as the control. Fungal growth was inhibited on the AgBr/NPVP-modified PMMA resin compared to the control (P < 0.05), and the antifungal activity increased as the incorporation of the AgBr/NPVP antimicrobial composite increased. Confocal laser scanning microscopy (CLSM) showed that the number of fungal cells attached to the modified PMMA resin was considerably lower than in the control. The relative growth rate of HDPCs of modified groups were higher than 75%. The flexural strength (FS) and flexural modulus (FM) were not significantly different (P > 0.05) between the experimental and control groups. These data indicate that the incorporation of AgBr/NPVP conferred strong and long-lasting antifungal effects against Candida albicans to the PMMA resin, and it has low toxicity toward HDPCs, and its mechanical properties were not significantly affected.

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Effect of a denture base acrylic resin containing silver nanoparticles onCandida albicansadhesion and biofilm formation

Abstract: Nano-silver had antifungal activity and inhibited C. albicans biofilm formation. Antifungal activity and an inhibitory effect on adhesion and biofilm formation by denture base resin containing nano-silver were discovered, especially at a higher concentration.

Cited by 96 publications

References 35 publications

Significance of polymethylmethacrylate (PMMA) modification by zinc oxide nanoparticles for fungal biofilm formation

Significance of polymethylmethacrylate (PMMA) modification by zinc oxide nanoparticles for fungal biofilm formation

PMMA denture base material enhancement: a review of fiber, filler, and nanofiller addition

The antifungal effects and mechanical properties of silver bromide/cationic polymer nano-composite-modified Poly-methyl methacrylate-based dental resin

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