Effect of a derived herbal recipe from an ancient Chinese formula, Danggui Buxue Tang, on ovariectomized rats

Xie, Qipeng; Xie, Jianhui; Dong, Tina Tingxia; Su, Juanjuan; Cai, Dake; Chen, Jianping; Liu, Liang-Feng; Li, Yucui; Lai, Xiaoping; Tsim, Karl Wah Keung; Su, Zi‐Ren

doi:10.1016/j.jep.2012.09.041

Cited by 49 publications

(31 citation statements)

References 41 publications

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“…It is worth mentioning that the stimulation of estrogen synthesis in our OVX animals agreed with the previous studies when the OVX rats were treated with other phytoestrogens. 13,29 Under physiological conditions, the biological effects of estrogen depend not only on the level of estrogen but also on the distribution and expression levels of the corresponding ERs, ERa and ERb, in the target cell [30][31][32] Estrogen and ERs are involved in the physiological function regulation of the female reproductive system. In this study, QBMR significantly up-regulated the expression of ERa and ERb in protein and gene levels in the target tissues, respectively.…”

Section: Discussionmentioning

confidence: 99%

Treatment with QiBaoMeiRan, a Kidney-Invigorating Chinese Herbal Formula, Antagonizes Estrogen Decline in Ovariectomized Rats

Ding

et al. 2014

Rejuvenation Research

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Traditional Chinese medicines (TCM) contain multi-interactive compounds that have been used for treatment of peri-menopausal syndrome and have become a new phytoestrogens resource. The QiBaoMeiRan formula (QBMR), including Polygoni Multiflori Radix, Angelicae Sinensis Radix, Achyranthis Bidentatae Radix, Semen Cuscutae, Fructus Lycii, Poria, and Fructus Psoraleae, has been used clinically for treating osteoporosis in post-menopausal women by virtue of its kidney-invigorating function. However, no evidence base links QBMR to estrogen replacement therapy. In this study, we undertook a characterization of estrogenic activity of QBMR using ovariectomized (OVX) rats. OVX rats were treated with QBMR at doses of 0.875, 1.75, and 3.5 grams/kg per day for 8 weeks. QBMR treatments demonstrated significant estrogenic activity, as indicated by vaginal cornification, reversal of atrophy of uterus, vagina, and mammary gland, and up-regulation of estrogen receptor a (ERa) and estrogen receptor b (ERb) expression in the reproductive target tissues, where ERb up-regulation was stronger than that of ERa. Meanwhile, treatment with QBMR significantly increased adrenal weight and serum estradiol levels and tended to decrease serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in a dose-dependent manner. Moreover, QBMR significantly decreased weight gain and rectal temperature increase caused by ovariectomy, and the largest changes in rectal temperature were found at the lowest dose. The data suggest that QBMR's estrogenic responses show tissue variation that reflects different affinities of ERs for QBMR components. This study demonstrates that QBMR activity is mediated through estrogenic components and provides an evidence base for QBMR treatment of post-menopausal symptoms.

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Section: Discussionmentioning

confidence: 99%

Treatment with QiBaoMeiRan, a Kidney-Invigorating Chinese Herbal Formula, Antagonizes Estrogen Decline in Ovariectomized Rats

Ding

et al. 2014

Rejuvenation Research

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“…RRF was prepared as described previously [19]. Amounts of RA, RAS, and FE were weighed according to a ratio of 5 : 1 : 5.…”

Section: Methodsmentioning

confidence: 99%

“…Previous pharmacological results suggested that DBT displays an estrogen-like activity on receptor phosphorylation without proliferating mammary gland cells [13], in addition to multiple abilities to promote hematopoietic function [14, 15], to prevent osteoporosis [16], and to stimulate immune response [17, 18]. Interestingly, our previous study on an ovariectomized model revealed that a herbal recipe (named RRF) derived from DBT, which includes Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii (leaves of Epimedium brevicornum Maxim, Berberidaceae), had a potential efficacy on both estrogen regulation and bone formation promotion [19], in which RRF exhibited the abilities to relieve the dramatic sexual hormonal unbalance of estradiol (E 2 ), lutenizing hormone (LH), and follicle stimulating hormone (FSH) and to restore the bone mineral density (BMD). All these findings strongly indicated the potential of RRF on prevention and treatment of women's perimenopausal symptoms.…”

Section: Introductionmentioning

confidence: 99%

Perimenopause Amelioration of a TCM Recipe Composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii: AnIn VivoStudy on Natural Aging Rat Model

Xie

Liu

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Traditional Chinese medicine (TCM) has been extensively applied as preferable herbal remedy for menopausal symptoms. In the present work, the potential of a TCM recipe named RRF, composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii, was investigated on a natural aging rat model. After administration of RRF (141, 282, and 564 mg/kg/d), the circulated estradiol (E2) level increased accompanied by a reduction of serum follicle stimulating hormone (FSH). But no significant impact on serum lutenizing hormone (LH) level was observed. As a result of the E2-FSH-LH adjustment, the histomorphology degenerations of ovary, uterus, and vagina of the 11.5-month female rats were alleviated. And lumbar vertebrae trabecular microstructure was also restored under RRF exposure by means of increasing the trabecular area and area rate. Moreover, levels of hypothalamic dopamine (DA) and norepinephrine (NE) rallied significantly after RRF treatment. Results from our studies suggest that RRF possesses a positive regulation on the estrogen imbalance and neurotransmitter disorder, thereby restoring reproductive organ degeneration and skeleton deterioration. The above-mentioned benefits of RRF on the menopause syndromes recommend RRF as a potential candidate for the treatment of perimenopausal syndrome.

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“…The most popular formulation is Danggui Buxue Tang (DBT) composed of Astragalus and Angelica at a 5 : 1 ratio, which is mainly used to treat anemia due to various causes via promoting hematopoiesis. 1) In recent years, studies have shown that DBT also has other pharmacological effects, such as enhancing immunity, 2) antagonizing diabetic nephropathy, 3) cardiovascular protection, 4) anti-fibrosis, 5,6) estrogen-like effect, 7,8) among others. Concerning the hematopoietic function of the AstragalusAngelica combination, most studies have revealed that Astragalus mixed with Angelica at 5 : 1 can strongly promote hematopoiesis.…”

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confidence: 99%

Effects of <i>Astragalus</i> Combined with <i>Angelica</i> on Bone Marrow Hematopoiesis Suppression Induced by Cyclophosphamide in Mice

Tang

Chen

et al. 2017

Biological & Pharmaceutical Bulletin

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Danggui Buxue Tang (DBT), a combination of Astragalus and Angelica at a 5 : 1 ratio, mainly promotes hematopoiesis. However, in the clinic, the combination ratio of Astragalus and Angelica to treat low hematopoietic function is not an absolute 5 : 1 ratio, suggesting that the herbs may promote hematopoiesis better after being combined at a certain range of ratios. The objective of this study is to investigate the effect of different ratio combinations of Astragalus and Angelica on bone marrow hematopoiesis suppression induced by cyclophosphamide (CTX) and to probe the interaction and mechanism of Astragalus combined with Angelica in promoting hematopoiesis. Following establishment of the model, mice were administered with Astragalus (6.00 g·kg 1

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Effect of a derived herbal recipe from an ancient Chinese formula, Danggui Buxue Tang, on ovariectomized rats

Cited by 49 publications

References 41 publications

Treatment with QiBaoMeiRan, a Kidney-Invigorating Chinese Herbal Formula, Antagonizes Estrogen Decline in Ovariectomized Rats

Treatment with QiBaoMeiRan, a Kidney-Invigorating Chinese Herbal Formula, Antagonizes Estrogen Decline in Ovariectomized Rats

Perimenopause Amelioration of a TCM Recipe Composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii: AnIn VivoStudy on Natural Aging Rat Model

Effects of <i>Astragalus</i> Combined with <i>Angelica</i> on Bone Marrow Hematopoiesis Suppression Induced by Cyclophosphamide in Mice

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