Effect of a diet based on Iranian traditional medicine on inflammatory markers and clinical outcomes in COVID-19 patients: A double-blind, randomized, controlled trial

Hajibeygi, Ramtin; Mirghazanfari, Sayid Mahdi; Pahlavani, Naseh; Jalil, Abduladheem Turki; Alshahrani, Shadia Hamoud; Rizaev, Jasur; Hadi, Saeid; Hadi, Vahid; Yekta, Nafiseh Hosseini

doi:10.1016/j.eujim.2022.102179

Cited by 15 publications

(6 citation statements)

References 29 publications

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“…Ethical approval for the study was obtained from the University of Health Sciences, Bursa Sehir Training & Research Hospital ethical committee (2023-12/7). The patients were classified according to CONUT scores as low (0-4) and High (5)(6)(7)(8)(9)(10)(11)(12), and further classified as Normal (0-1), Mild (2-4), Moderate (5-9), and High (9)(10)(11)(12). The data was compared among the groups.…”

Section: Methodsmentioning

confidence: 99%

“…A higher CONUT score implies poor nutritional status, with higher scores linked to more significant morbidity and mortality. CONUT scores were classified as low (0-4) and High (5)(6)(7)(8)(9)(10)(11)(12), and further classified as Normal (0-2), Mild (3-4), Moderate (5-9), and High (9-12).…”

Section: Calculationsmentioning

confidence: 99%

“…Moreover, a comprehensive systematic review of Malekahmadi et al [ 6 ] delves into the advantages of employing an enteral immunomodulatory nutrition formula in managing inflammation and oxidative stress in various acute conditions, aiming to improve survival and critical care parameters. The research by Hajibeygi et al [ 7 ] underscores the pivotal role of dietary interventions in mitigating inflammation and potentially reducing oxidative stress in critically ill COVID-19 patients.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of nutritional status and clinical outcomes: A comprehensive retrospective analysis of critically ill patients

Özkan,

Koca,

Tekeli

2023

Medicine

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Assessing nutritional status is vital for understanding and managing patients’ clinical conditions. Controlling Nutritional Status (CONUT) score is one of the most frequently used scores that evaluate caloric status, protein reserve, and immunological response estimation. This study assesses the critically ill patients’ nutritional status and its relationship with patient-related factors and mortality. Electronic medical records of 1687 Intensive Care Unit (ICU) patient files were reviewed from January 2019 to May 2023 retrospectively. Patient demographic information, clinical characteristics, and laboratory data were extracted and anonymized for analysis. The patients were divided according to the CONUT scores, and retrieved data were compared. The study population’s demographic features and clinical outcomes were stratified by CONUT scores. The gender distribution was similar; however, there was a significant age difference between the Low-CONUT and High-CONUT groups (P < .001). High CONUT values are linked to an increased risk of death, intubation, age, APACHE-II scores, and the number of comorbidities. Malnutrition is prevalent in ICU patients with gastrointestinal illnesses and urogenital system disorders, including infections. Patients with a high CONUT score at admission had an increased risk of ICU death even after correcting for covariates. The CONUT score is a trustworthy and practical tool for assessing ICU patients’ nutritional status, which is highly associated with ICU mortality. Patients admitted to the ICU with gastrointestinal, urogenital, or infectious disorders should have their nutritional condition assessed carefully. According to our study, the rate of intubated patients admitted to the intensive care unit is higher in malnourished patients. This suggests it should be reviewed in clinical settings, particularly in elderly, frail patients and those with numerous comorbidities.

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Section: Methodsmentioning

confidence: 99%

Section: Calculationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of nutritional status and clinical outcomes: A comprehensive retrospective analysis of critically ill patients

Özkan,

Koca,

Tekeli

2023

Medicine

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“…Nutrition plays a pivotal role in enhancing these immune response mechanisms, thereby bolstering the body’s ability to defend against pathogens [ 8 – 10 ]. Studies have demonstrated a notable increase in the risk of mortality and adverse events during hospitalization among adult COVID-19 patients with nutritional deficiencies or malnutrition [ 11 – 13 ]. In COVID-19 patients, malnutrition or susceptibility to malnutrition correlates with heightened inflammation and compromised immune function, potentially exacerbating disease progression and complicating its outcomes [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

A randomized clinical trial investigating the impact of magnesium supplementation on clinical and biochemical measures in COVID-19 patients

Rostami,

Alavi,

Daghagheleh

et al. 2024

Virol J

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Background This study sought to examine the impact of magnesium supplementation on clinical outcomes and biochemical factors among hospitalized patients with COVID-19. Methods This double-blind, randomized clinical trial was conducted at Razi Hospital, Ahvaz, Iran, between September 2021 and March 2022. Participants aged 18–70 years with moderate disease severity were enrolled. Magnesium supplementation (300 mg daily) was administered to the intervention group, while the control group received a placebo. Clinical outcomes, including the need for oxygen therapy, oxygen saturation, respiratory rate, fever, hs-CRP and TNF-α levels, as well as quality of life and mental health, were assessed. Blood samples were collected to measure biochemical variables. Results The main result was the count of individuals requiring oxygen therapy. Additional outcomes comprised of oxygen saturation, respiratory rate, fever, hs-CRP and TNF-α levels, as well as quality of life and mental health. Out of 64 participants, 60 completed the study. The results showed that magnesium supplementation significantly reduced the number of patients requiring oxygen therapy (9 vs. 14; P < 0.001). Moreover, the magnesium group demonstrated improved oxygen saturation compared to the control group (4.55 ± 2.35 vs. 1.8 ± 1.67; P < 0.001). Furthermore, we observed a noteworthy enhancement in the quality of life and depression score in the magnesium group. No significant differences were observed in respiratory rate, fever, hs-CRP, and TNF-α levels (P > 0.05). Conclusion The findings suggest that magnesium supplementation may have beneficial effects on clinical outcomes and arterial oxygen saturation in COVID-19 patients. More investigation is necessary to delve into its potential mechanisms and long-term effects on patient outcomes. Trial registration This study is registered on Iranian Registry of Clinical Trials (IRCT) under identifier IRCT20210413050957N1. (The registration date: May 1, 2021).

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“…In this regard, it is essential to have a healthy diet that includes foods rich in antioxidants and anti-infammatory compounds. Tese nutrients can help support the immune system and minimize the adverse efects of infammation and oxidative stress on overall health [13][14][15]. Terefore, diet and healthy lifestyles play pivotal roles in both the prevention and management of COVID-19 and its long-term consequences [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

The Effects of an Eight-Week Swimming Program on Body Composition and Assessment of Dietary Intake in Post-COVID-19 Patients

Jakše,

Gilić,

Đurović

et al. 2024

Journal of Nutrition and Metabolism

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COVID-19 infection and its consequences (long-term COVID-19 syndrome) have implications for weight loss, body composition, and diet quality. In the context of the “PostCovSwim” project, which is part of a broader international study, the impact of an eight-week swimming program on post-COVID-19 patients’ nutritional status (i.e., body composition and dietary intake) was evaluated. Body composition and dietary intake were assessed by medically approved and calibrated bioelectrical impedance (Tanita 780 S MA) and food frequency questionnaires. At the baseline, most participants were classified as overweight based on their body mass index (BMI). However, their body fat percentage (BF%) classification indicated normal weight, although females were near obesity thresholds. Furthermore, at the baseline, according to the BMI classification, 62% of females and 61% of males were female, whereas according to the BF% for obesity classification, 44% of females and 43% of males were considered overweight or obese. Surprisingly, despite the eight-week program, there were no significant changes in body composition. Additionally, the assessment of dietary intake, which remained consistent throughout the study, revealed dietary imbalances characterized by an unhealthy low-carbohydrate, high-fat dietary pattern. This dietary pattern entailed excessive consumption of ultraprocessed foods; reduced carbohydrate intake (39% E vs. 37% E); increased total fat intake (46% E vs. 47% E); increased saturated fatty acids (14% E vs. 13% E); increased cholesterol (412 mg/d vs. 425 mg/d); increased free sugars (7% E vs. 7% E); and inadequate intake of fibre (24 g/d vs. 20 g/d), polyunsaturated fatty acids (6.6% E vs. 7.7% E), vitamin B12 (in females: 3.1 µg/d), vitamin C (86 mg/d vs. 66 mg/d), vitamin D (2 µg/d vs. 3.2 µg/d), folate (in males: 258 µg/d), calcium (777 mg/d vs. 743 mg/d), and selenium (in males: 66 µg/d). After an eight-week swimming program following COVID-19, no significant changes were observed in the subjects’ body composition. Their dietary intake was found to not align with the dietary recommendations. These findings underscore the urgency of implementing comprehensive dietary and lifestyle interventions for post-COVID-19 patients to optimize their recovery and overall well-being. Physical activity, like a swimming program, may positively affect various aspects of human well-being.

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Effect of a diet based on Iranian traditional medicine on inflammatory markers and clinical outcomes in COVID-19 patients: A double-blind, randomized, controlled trial

Cited by 15 publications

References 29 publications

Assessment of nutritional status and clinical outcomes: A comprehensive retrospective analysis of critically ill patients

Assessment of nutritional status and clinical outcomes: A comprehensive retrospective analysis of critically ill patients

A randomized clinical trial investigating the impact of magnesium supplementation on clinical and biochemical measures in COVID-19 patients

The Effects of an Eight-Week Swimming Program on Body Composition and Assessment of Dietary Intake in Post-COVID-19 Patients

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