Effect of a Dietary Supplement Combining Bioactive Peptides and Magnesium on Adjustment Disorder with Anxiety: A Clinical Trial in General Practice

Abstract

Anxiety is a high frequency disorder in the general population. It is usually treated with benzodiazepines, which cause side effects and a dependence that could make withdrawal difficult. Alternative treatments are therefore needed to reduce the use of anxiolytics, particularly for adjustment disorder with anxiety. An observational, multicentre, prospective, longitudinal study has been conducted by general practitioners and one gynaecologist to evaluate the efficacy of a dietary supplement on adjustment disorder with anxiety (Stress 2 study). Patients diagnosed as anxious with a score of ≥ 20 on the Hamilton Anxiety Rating Scale (Ham-A, first visit on Day 0 (V0)) were offered a 28-day treatment with a dietary supplement formulated with bioactive peptides from a fish protein hydrolysate (Gabolysat®), magnesium and vitamin B6. At the second visit (V1), the Ham-A Rating Scale, the Patient Global Impression scale (PGI) and the Clinical Global Impressions scale (CGI) were administered. A 50% reduction in the Ham-A score, was achieved for 41.9% of the patients. The mean Ham-A score decreased by 12.1 ± 5.7 points (p < 0.001) between V0 (25.6 ± 3.8) and V1 (13.6 ± 6.0). Furthermore, according to the CGI scale, the anxiety of 75.3% of patients improved significantly and very significantly, with limited side effects and a negligible rebound effect. In conclusion, adjustment disorder with anxiety seems to be effectively managed by an alternative and safer solution than benzodiazepines.

Association between skin disease and anxiety: a logistic analysis and prediction

“…In this study, we collected the data of 214 patients from the Wuhan Institute of Dermatology and Venereology between January 2020 and January 2022, including demographic data, disease diagnosis, Hamilton Anxiety Rating Scale (HAMA) ( 18 ), and anxiety outcome. According to the anxiety assessment results of the included samples, patients were divided into an anxiety group (n=50) and a nonanxiety group (n=164).…”

“…The HAMA was developed by Hamilton in 1959 and includes 14 items ( 18 , 19 ): (I) anxiety mood; (II) tension; (III) fear; (IV) insomnia; (V) cognitive function; (VI) depression mood; (VII) somatic anxiety (muscle system symptoms); (VIII) sensory system symptoms; (IX) cardiovascular system symptoms; (X) respiratory system symptoms; (XI) gastrointestinal and digestive tract symptoms; (XII) reproductive and urinary system symptoms; (XIII) autonomic nervous system symptoms, and (XIV) behavior when talking to people. In this study, 2 trained assessors jointly evaluated patients with the HAMA through conversation and observation.…”

A Review on the Scope of Homoeopathic Medicines in Managing Adjustment Disorder

“…[12] In another study, it was found that dietary supplements showed better results in managing adjustment disorder as compared to benzodiazepines. [13] Studies conducted by Oliha and Audu (2010) on Adolescents with maladjustment, reveal that Rational Emotive Therapy and Systematic desensitization were effective in promoting emotional adjustment. [14] Recent case series by Karunakaran et al, reveal that maladjustment can be effectively treated by Homoeopathic medication.…”

Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder

“…The differences in the concentrations of Ca and Mg were not significant. On the other hand, there is evidence of the efficacy of a dietary supplement with magnesium on adjustment anxiety disorders [ 23 ].…”