Effect of a Diphtheria Booster Vaccination in Adults with a Documented History of an Incomplete Primary Series Vaccination

Hasselhorn, Hans Martin; Hofmann, Friedrich; Nübling, Matthias

doi:10.1007/s15010-004-3149-2

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Other parameters such as sex (Ref. 89), obesity (Ref. 90) and the composition of the T-cell repertoire ( Refs 49,50,91) have also been proposed to contribute to the decline of the protective effect of vaccination in old age and therefore could be potential targets for increasing vaccine efficacy.…”

Section: Strategies To Improve Vaccine Efficacy In the Elderlymentioning

confidence: 99%

Age-related changes in immunity: implications for vaccination in the elderly

Kovaiou

Herndler‐Brandstetter

Grubeck‐Loebenstein

2007

Expert Rev. Mol. Med.

144

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Average life expectancy is continuously rising in all developed countries, leading to an ever-increasing elderly population. Of the many functions of the body affected by the complex process of ageing, the immune system in particular undergoes various changes, collectively termed immunosenescence. As a result, elderly people are more susceptible to infections and are frequently less protected by vaccines. This review summarises the effect of ageing on immunity, emphasising the age-associated changes within T and B cells at a molecular and cellular level. Furthermore, it discusses strategies, such as the addition of immunostimulatory adjuvants and the use of potent antigen-delivery systems, that may counteract age-related defects in immune responses to vaccination. A proper understanding of how immunological memory is affected by ageing, and the introduction of strategies to ameliorate vaccine efficacy in the elderly, might reduce the incidence and the severity of infectious disease within this fragile age group and have a strong impact on the quality of life of elderly individuals.

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Section: Strategies To Improve Vaccine Efficacy In the Elderlymentioning

confidence: 99%

Age-related changes in immunity: implications for vaccination in the elderly

Kovaiou

Herndler‐Brandstetter

Grubeck‐Loebenstein

2007

Expert Rev. Mol. Med.

144

View full text Add to dashboard Cite

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Sex-dependent immune responses to infant vaccination: an individual participant data meta-analysis of antibody and memory B cells

Voysey

Barker

Snape

et al. 2016

Vaccine

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Supplementary table 1: Vaccines received as part of the study protocol and adjusted for in the analysisMnCC=Menjugate, MnACp=capsular group A + C meningococcal polysaccharide vaccine, MenACWY= capsular groups A,C,W,Y meningococcal conjugate vaccine, MenACWY-= meningococcal ACWY conjugate vaccine (without adjuvant), 9vPnC-MnCC= capsular group C meningococcal + 9 valent pneumococcal polysaccharide-CRM197 conjugate vaccine, MenC-TT= NeisVac-C, Hib-MenC-TT=Menitorix, MMR=measles mumps rubella vaccine, DTaP-IPV-Hib=Pediacel, OPV=oral polio vaccine, Pn=pneumococcal, PCV10= Synflorix, PV13=Prevenar-13. Table 2 : Individual participant data meta-analysis of immunological endpoints by vaccine antigen PRP: Polyribosylribitol phosphate, hSBA: serum bactericidal assay (human complement), rSBA: serum bactericidal assay (rabbit complement), IgG: immunoglobulins, GMR: geometric mean ratio. Heterogeneity p value from sexby-study interaction term in models which included at least 3 studies. Meta-analysis of pneumococcal serotype-specific differences in proportions with IgG > 0.35μg/mL (female -male) *Results from an unadjusted two-stage random effects meta-analysis of proportions. Supplementary Supplementary Supplementary Figure 1:Individual participant data meta-analyses of pneumococcal serotype specific opsonophagocytic activity for vaccine serotypes. Each point estimate represents the summary GMR from one meta-analysis. Lines indicate 95% confidence intervals. A GMR of 1.0 represents no difference in responses between females and males. 5 months = one-month post-prime, 12 months = pre-boost, 13 months = one-month post-boost, 24 months = persistence at one year post-boost.

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Effect of a Diphtheria Booster Vaccination in Adults with a Documented History of an Incomplete Primary Series Vaccination

Abstract: A specific immunologic memory exists in adults with a history of only two previous diphtheria vaccinations. However, our results also indicate the need for a second booster vaccination in this group if long-term protection is to be achieved.

Cited by 2 publications

References 14 publications

Age-related changes in immunity: implications for vaccination in the elderly

Age-related changes in immunity: implications for vaccination in the elderly

Sex-dependent immune responses to infant vaccination: an individual participant data meta-analysis of antibody and memory B cells

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