Effect of a fascial tissue interface on silicone implant capsule formation – a preliminary experimental study

Uzunismail, Adnan; Perk, Cem; Findik, Hasan; Beyhan, Goekhan; Dincler, Mahmut

doi:10.1016/j.bjps.2007.06.030

Cited by 15 publications

(9 citation statements)

References 15 publications

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“…In addition, since experimental models are rarely able to replicate the development of capsular contracture, most studies evaluate the outcome of different interventions on normal capsule formation in their animal models (Vieira et al 2010, Dobke et al 1995, Rieger et al 2013, Bastos et al 2003, 2007a, Imber et al 1974, Ksander et al 1981, Peters et al 1980, Chelko et al 2012, Aparecida da Silva et al 2014, Shin et al 2013, Uzunismail et al 2008, Chang et al 1992, Hester et al 1988, Asplund et al 1996, Thuesen et al 1995, Puckett et al 1987, Hakelius and Ohlsen 1997, Handel et al 1995, Lemperle and Exner 1993, Zimman 2007, Bergmann et al 2012, Hester et al 2001, Lilla and Vistes 1976, Brand 1984. This fact understates the impact of conclusions from previous studies, since therapy should be focused in pathologic capsule formation.…”

Section: Discussionmentioning

confidence: 99%

“…There are some studies with rabbits trying to understand the capsular contracture process, but interestingly, most of them use smooth surface mini-implants only (Shin et al 2013, Moyer et al 2012, Adams et al 2006). To our knowledge, a single rabbit study compared textured and smooth surface silicone mini-implant, and found less cellularity and reduced capsule thickness surrounding textured surface prostheses (Uzunismail et al 2008). Minami et al (2006) used pigs to show that capsular contracture in smooth implants have a significantly higher intra-implant pressure, and the smooth implant capsule was significantly thicker than the textured (Minami et al 2006).…”

Section: Pu (Polyurethane); Tgf-β1 (Transforming Growth Factor-beta 1mentioning

confidence: 99%

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Capsular Contracture In Silicone Breast Implants: Insights From Rat Models

Vieira

d'Acâmpora

Neves

et al. 2016

An. Acad. Bras. Ciênc.

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Breast augmentation with silicone implants is one of the most common procedures performed by plastic surgeons around the world. Capsular contracture is a frequent complication in breast augmentation and reconstructive surgery, that requires invasive intervention. The inflammatory response to implanted mammary prostheses appears to be directly associated to capsular contracture. This review discusses the evidences from rat models studies, on the role of inflammation and fibrosis in capsular contraction and its relation to silicone breast implants surface.

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Section: Discussionmentioning

confidence: 99%

Section: Pu (Polyurethane); Tgf-β1 (Transforming Growth Factor-beta 1mentioning

confidence: 99%

Capsular Contracture In Silicone Breast Implants: Insights From Rat Models

Vieira

d'Acâmpora

Neves

et al. 2016

An. Acad. Bras. Ciênc.

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“…In fact, fascial flaps, placed around implants, have been used to decrease capsule formation in rabbits. 24 This may also explain recent findings that acellular dermal matrices can decrease the rate of capsular contracture when placed adjacent to an implant. 25 Photochemical cross-linking of collagen scaffolds has also been found to reduce both platelet adhesion and fibrin mesh formation.…”

Section: Discussionmentioning

confidence: 85%

Prevention of Capsular Contracture with Photochemical Tissue Passivation

Fernandes

Austen²

2014

Plastic and Reconstructive Surgery

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“…On the contrary, ACMs presented a different tissue response. This suggests that using biological materials as implant beds avoiding direct contact between the silicone prosthesis and the resident tissue could favour a physiological integration [30]. Schmitz et al [25] reported that the implantation of an acellular dermal matrix covering a silicone prosthesis reduced the rate of inflammation in rats [25].…”

Section: Discussionmentioning

confidence: 99%

Tissue-Material Integration and Biostimulation Study of Collagen Acellular Matrices

Sierra

Busato

Zingaretti

et al. 2022

Tissue Eng Regen Med

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Background: Breast reconstruction after mastectomy using silicone implants is a surgical procedure that occasionally leads to capsular contracture formation. This phenomenon constitutes an important and persistent cause of morbidity, and no successful therapies are available to date. Recently, the use of acellular membranes as a protective material for silicone prostheses has been gaining attention due to their ability to prevent this adverse outcome. For this reason, the evaluation of the tissue-material integration and the induced biostimulation by acellular membranes results crucial. Evaluation of in vivo tissue integration and biostimulation induced by three different natural acellular collagen membranes. Methods: Scanning electron microscopy was performed to analyse the membrane porosity and cells-biomaterial interaction in vitro, both in dry and wet conditions. Adipose-derived stem cells were cultured in the presence of membranes, and the colonisation capacity and differentiation potential of cells were assessed. In vivo tests and ex vivo analyses have been performed to evaluate dermal integration, absorption degree and biostimulation induced by the evaluated membrane. Results: Analysis performed in vitro on the three different acellular dermal matrices evidenced that porosity and the morphological structure of membranes influence the liquid swelling ratio, affecting the cell mobility and the colonisation capacity. Moreover, the evaluated membranes influenced in different manner the adipose derived stem cells differentiation and their survival. In vivo investigation indicated that the absorption degree and the fluid accumulation surrounding the implant were membrane-dependent. Finally, ex vivo analysis confirmed the membrane-dependent behavior revealing different degree of tissue integration and biostimulation, such as adipogenic stimulation. Conclusion: The physico-chemical characteristics of the membranes play a key role in the biostimulation of the cellular environment inducing the development of well-organized adipose tissue.

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Effect of a fascial tissue interface on silicone implant capsule formation – a preliminary experimental study

Cited by 15 publications

References 15 publications

Capsular Contracture In Silicone Breast Implants: Insights From Rat Models

Capsular Contracture In Silicone Breast Implants: Insights From Rat Models

Prevention of Capsular Contracture with Photochemical Tissue Passivation

Tissue-Material Integration and Biostimulation Study of Collagen Acellular Matrices

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