Effect of a fraction of bovine hypothalamic extract on the release of TSH by rat adenohypophysesin vitro

Schreiber, V; Eckertova, A; Franc, Z; Kočí, Jaromír; Rybák, M.; Kmentova, V

doi:10.1007/bf02161432

Cited by 28 publications

(3 citation statements)

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“…Since it had been established that a vascular link in which blood flowed from the hypothalamus to the APG was the only connection between these two organs, it was also concluded that a humoral substance had been formed in the hypothalamus and secreted into the vascular link to stimulate TSH release. Investigators who attempted to find this TSH neuroregulator were indeed successful (3)(4)(5). This chemical or hormone was designated as the thyrotrophin-releasing factor (TRF) or thyrotrophinreleasing hormone (TRH) (6) and was found in the hypothalamus of the sheep, ox, pig, rat and human (4,(7)(8)(9).…”

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confidence: 99%

Effect of Thyrotropin-Releasing Factor in Man

Bowers

Hawley

Gual

et al. 1968

The Journal of Clinical Endocrinology & Metabolism

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This study reports the changes of plasma TSH levels which occurred when a highly purified preparation of porcine TRF was given to 3 cretins. These results in man indicate a certain lack of species specificity since TRF prepared from the hypothalami of pigs was active in the mouse and rat as well as man. The levels of TSH were measured by both bioassay and radioimmunoassay and were found to rise within 3 min in 2 of the patients and by 6 min in all 3 patients. The greatest rise was from 6 to 30 min and was followed by a gradual decline of the TSH level over the next 45 min. When the plasma level of TSH was measured in one of the patients 120 min after injecting TRF, it had returned to the base line level. Some conditions considered important for testing the activity of TRF in man are given. Because of the limited supply of TRF available, it was not possible to determine if the above were the optimal conditions for detecting the TRF response in man. (J Clin Endocr 28: 978,1968) A SERIES of beautiful and specific studies was performed within the last 20 years which indicated that thyrotropin (TSH) released from the anterior pituitary gland (APG) was dependent on the hypothalamus (1, 2). To increase the release of TSH with electrodes placed into the hypothalamus, it was necessary to stimulate the preoptic area. To decrease the release of TSH it was found that either the removal of the pituitary gland and its transplantation away from its normal anatomical site, the severing of the anatomical connection between the hypothalamus and pituitary gland, or the localized destruction of specific areas in the hypothalamus was effective in each instance. It was concluded from these studies that the hypothalamus and anterior pituitary gland functioned as a unit to regulate TSH release. Since it had been established that a vascular link in which blood flowed from the hypothalamus to the APG was the only connection between these two organs, it was also concluded that a humoral substance had been formed in the hypothalamus and secreted

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mentioning

confidence: 99%

Effect of Thyrotropin-Releasing Factor in Man

Bowers

Hawley

Gual

et al. 1968

The Journal of Clinical Endocrinology & Metabolism

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“…Thyrotropin releasing activity (TRF) was reported to be present in hypothalamic extracts by Schreiber et al [50] in 1961, and later this was confirmed by Guillemin et al [15], The first convincing demonstration of growth hor mone releasing activity (GHRF or GRF) in hypothalamic extract was reported in 1963-1964 by Deuben and Meites [7], although an earlier claim had been made for the existance of such a factor by Franz, Haselbach, and Leibert in 1962. When AP tissue was incubated with hy pothalamic extract in vitro, release of GH ceased after a few days, but if hypothalamic extract was then added, GH release resumed [7].…”

Section: Role Of Hypothalamic Neurotransmitters In Regulating Ap Funcmentioning

confidence: 65%

Short History of Neuroendocrinology and the International Society of Neuroendocrinology

Meites

1992

Neuroendocrinology

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“…The hypothalamic-pituitary-thyroid (HPT) axis is the neuroendocrine thyrotropic axis (Figure 2). After indirect evidence of the existence of a thyrotropin-releasing factor in dogs (Shibusawa et al, 1955), a fraction, purified from bovine or ovine hypothalamic extracts, was found to stimulate the release of TSH (Schreiber et al, 1961;Guillemin et al, 1962Guillemin et al, , 1963. The TRH gene encodes multiple identical repeats of the three amino-acid (pyroglutamic acid-histidine-proline) TRH sequence (Galas et al, 2009).…”

Section: Thyrotropin-releasing Hormone and Its Receptorsmentioning

confidence: 99%

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

2021

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Post-embryonic acute developmental processes mainly allow the transition from one life stage in a specific ecological niche to the next life stage in a different ecological niche. Metamorphosis, an emblematic type of these post-embryonic developmental processes, has occurred repeatedly and independently in various phylogenetic groups throughout metazoan evolution, such as in cnidarian, insects, molluscs, tunicates, or vertebrates. This review will focus on metamorphoses and developmental transitions in vertebrates, including typical larval metamorphosis in anuran amphibians, larval and secondary metamorphoses in teleost fishes, egg hatching in sauropsids and birth in mammals. Two neuroendocrine axes, the hypothalamic-pituitary-thyroid and the hypothalamic-pituitary-adrenal/interrenal axes, are central players in the regulation of these life transitions. The review will address the molecular and functional evolution of these axes and their interactions. Mechanisms of integration of internal and environmental cues, and activation of these neuroendocrine axes represent key questions in an “eco-evo-devo” perspective of metamorphosis. The roles played by developmental transitions in the innovation, adaptation, and plasticity of life cycles throughout vertebrates will be discussed. In the current context of global climate change and habitat destruction, the review will also address the impact of environmental factors, such as global warming and endocrine disruptors on hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal/interrenal axes, and regulation of developmental transitions.

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Effect of a fraction of bovine hypothalamic extract on the release of TSH by rat adenohypophysesin vitro

Cited by 28 publications

References 1 publication

Effect of Thyrotropin-Releasing Factor in Man

Effect of Thyrotropin-Releasing Factor in Man

Short History of Neuroendocrinology and the International Society of Neuroendocrinology

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

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