Effect of a gluten-free diet on bone mineral density in children with celiac disease

Heyman, Richard A.; Guggenbuhl, Pascal; Corbel, Amanda; Bridoux-Henno, Laure; Tourtelier, Y.; Balençon-Morival, M.; Kerdanet, M. de; Dabadie, A.

doi:10.1016/j.gcb.2008.09.020

Cited by 22 publications

(20 citation statements)

References 23 publications

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“…Current research shows that low BMD improves approximately one year after treatment of CD with a strict gluten-free diet [11,12,13]. This suggests that we may not need to screen patients who are compliant with their diet.…”

Section: Discussionmentioning

confidence: 99%

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Understanding the Variation in Use of Screening DXA Scans in Pediatric Patients with Celiac Disease

Webster¹,

Shaw²,

Shea³

et al. 2017

IJCD

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Celiac disease (CD) is an immune-mediated genetic disorder occurring secondary to gluten exposure and increasing the likelihood of low bone mineral density (BMD). As there are no published guidelines for dual-x-ray absorptiometry (DXA) scanning in pediatric CD patients, we characterized current practices of pediatric gastroenterologists in ordering screening DXA scans for pediatric CD patients. To accomplish this, A REDCap survey was distributed to the NASPGHAN listserv. There was a total of 231 (11%) responses. The majority (60%) of clinicians do not order screening DXA scans because they don't believe it is clinically necessary. Patient factors influenced ordering screening DXA scans with fracture history driving ordering and tissue transglutaminase (tTG) level not affecting practice. Physician factors such as practice type and experience were not associated with ordering screening DXA scans. Case scenarios, showed wide variation in management based on DXA results.

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Section: Discussionmentioning

confidence: 99%

“…There is also evidence that adherence to a gluten-free diet can reverse intestinal mucosal damage as well as the resulting abnormalities in growth and bone mineral density [7,11,12,13].…”

Section: Introductionmentioning

confidence: 99%

Understanding the Variation in Use of Screening DXA Scans in Pediatric Patients with Celiac Disease

Webster¹,

Shaw²,

Shea³

et al. 2017

IJCD

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“…Confusing results on the relationship between GFD and metabolism have been provided: most of studies demonstrated a lower prevalence of low BMD in coeliac patients who are on GDF (16,29), as well as GFD exert a beneficial effect on bone metabolism of coeliac patients (30)(31)(32). A similar prevalence of low BMD have been documented after one (33) and three years (34) on GFD, which shows that the main recovery in bone mass is reached in the first year of following the diet.…”

Section: Discussionmentioning

confidence: 99%

Does dermatitis herpetiformis result in bone loss as coeliac disease does?: a cross sectional study

Lőrinczy

Juhász

Csontos

et al. 2013

Rev. esp. enferm. dig.

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Introduction and objectives: coeliac disease (CD) and its cutaneous manifestation, dermatitis herpetiformis are both (DH) glutensensitive diseases. Metabolic bone disease is common among patients with CD, even in asymptomatic forms. Data are scarce about bone density in patients with dermatitis herpetiformis. The aim of our study was to compare bone mineral density (BMD) of celiac and dermatitis herpetiformis patients.Methods: 34 coeliac patients, 53 with dermatitis herpetiformis and 42 healthy controls were studied. The mean age was 38.0 ± 12.1, 32.18 ± 14.95, 35.33 ± 10.41 years in CD, dermatitis herpetiformis, and healthy controls, respectively. Bone mineral density of the lumbar spine, the left femoral neck and radius were measured by dual-energy X-ray absorptiometry. Low bone density, osteopenia and osteoporosis were defined as a body mass density (BMD) T-score between 0 and -1, between -1 and -2.5, and under -2.5, respectively.Results: at lumbar region, consisting of dominantly trabecular compartment, a decreased BMD was detected in 49 % (n = 26) patients with dermatitis herpetiformis, 62 % (n = 21) of CD patients, and 29 % (n = 12) of healthy controls, respectively. Lower BMD were measured at the lumbar region in dermatitis herpetiformis and CD compared to healthy subjects (0.993 ± 0.136 g/cm 2 and 0.880 ± 0.155 g/cm 2 vs. 1.056 ± 0.126 g/cm 2 ; p < 0.01). Density of bones consisting of dominantly cortical compartment (femoral neck) did not differ in dermatitis herpetiformis and healthy subjects.Conclusions: our results show that a low bone mass is also frequent among patients with dermatitis herpetiformis. Bone mineral content in these patients is significantly lower in those parts of the skeleton which contain more trabecular than cortical bone.

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“…Анализ взаимосвязи между антропометрическими показателями и костным возрастом детей с целиакией подчеркивает существующую прямую корреляцию между нарушением скорости роста и задержкой созревания костного скелета [51,52]. Замедление темпов линейного роста закономерно приводит к снижению МПКТ [52].…”

Section: Vdr Vdrunclassified

“…Замедление темпов линейного роста закономерно приводит к снижению МПКТ [52]. По данным R. Heyman и соавт., задержка костного возраста и снижение минерализации костной ткани формируются у 59% пациентов [51].…”

Section: Vdr Vdrunclassified

Hormonal-metabolic patterns disorders of bone tissue mineralization in children with celiac disease

Klimov¹,

Абрамская²,

Stoian³

et al. 2017

Med. sov.

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Effect of a gluten-free diet on bone mineral density in children with celiac disease

Cited by 22 publications

References 23 publications

Understanding the Variation in Use of Screening DXA Scans in Pediatric Patients with Celiac Disease

Understanding the Variation in Use of Screening DXA Scans in Pediatric Patients with Celiac Disease

Does dermatitis herpetiformis result in bone loss as coeliac disease does?: a cross sectional study

Hormonal-metabolic patterns disorders of bone tissue mineralization in children with celiac disease

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