Effect of a gluten free diet on osteopenia in adults with newly diagnosed coeliac disease.

Mcfarlane, X. A.; Bhalla, A. K.; Robertson, Douglas R.

doi:10.1136/gut.39.2.180

Cited by 110 publications

(75 citation statements)

References 13 publications

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“…12,20 In adults, some reports found a low effect of the GFD for 1 year, 3,4,21 whereas the others showed a remarkable improvement of bone mineralization for the same period. 5,[22][23][24] Ciacci 25 concluded that recovery of low BMD seemed probable only if GFD was started before the age of 25. In our study, the BMD values of the newly diagnosed patients improved remarkably after 1 year of GFD.…”

Section: Discussionmentioning

confidence: 99%

Bone Mineral Density and Importance of a Gluten-Free Diet in Patients With Celiac Disease in Childhood

Kalaycı

Kansu²,

Girgin³

et al. 2001

Pediatrics

115

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ABSTRACT. Objectives. Celiac disease (CD), a common cause of malabsorption, is known to be associated with disorders of the skeleton, but there are conflicting data about the effect of diet on bone metabolism. The aims of this study were to investigate the prevalence of osteopenia; to identify the relationship between bone mineral density (BMD), serum calcium, and parathyroid hormone levels; and to determine the effect of glutenfree diet on BMD in children with celiac disease.Design. The study included 32 patients with CD (group 1) and 82 healthy controls (group 2). The patients with CD were evaluated under 2 subgroups, ie, 16 patients with recent diagnosis (group 1a) and 16 patients who follow their diet strictly (group 1b). BMD values and concentrations of calcium, phosphorus, alkaline phosphatase, and intact parathyroid hormone were determined on entry to the study and at 12 months in celiac patients. These values were compared with those of healthy control participants.Results. BMD and bone mineral content values in patients with recent diagnosis were found to be significantly lower than the control group. The BMD values in patients with recent diagnosis were significantly increased after a gluten-free diet for 1 year. Osteopenia was found more commonly in patients with recent diagnosis than patients in whom a gluten-free diet had been instituted. At 1-year follow-up, osteopenia was not resolved with the gluten-free diet, and this was especially true in patients without gastrointestinal manifestation. In patients with recent diagnosis (group 1a), the mean calcium level was found to be lower than the patients who follow their diet strictly (group 1b). There was a positive correlation between calcium level and BMD and bone mineral content.Conclusions. BMD is almost invariably low in newly diagnosed celiac patients in childhood. We therefore recommend that BMD should be evaluated in patients with CD. Strict gluten avoidance promoted a significant increase in BMD. However, values still remained markedly low after 1 year of follow-up in some patients. These patients should be followed for longer periods of time with yearly BMD evaluation, as 1 year of diet therapy was found to be insufficient for osteopenia to be resolved. Pediatrics 2001;108(5). URL: http://www. pediatrics.org/cgi/content/full/108/5/e89; bone mineral density, celiac disease, gluten-free diet, osteopenia, osteoporosis, childhood.

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Section: Discussionmentioning

confidence: 99%

Bone Mineral Density and Importance of a Gluten-Free Diet in Patients With Celiac Disease in Childhood

Kalaycı

Kansu²,

Girgin³

et al. 2001

Pediatrics

115

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“…Bone disease Improvement in bone mineral density [53][54][55][56][57][58][59][60] , including postmenopausal women and those without complete duodenal mucosal recovery 53 Normal bone mineralization long term in children and adults 59,352 Nutritional status Increase in body weight, body mass index, fat mass, bone mass and triceps skin fold thickness 359 Improved in fat mass but not indices of lean body mass 84 Improved nutrition and height velocity in Asian children 360 Prevention of nutrient deficiencies, in particular, iron deficiency anaemia 7,51 Improved calcium absorption from the gut 361 though not to normal values 47 Parathyroid hormone levels return to normal 47,59 .…”

Section: Malignancymentioning

confidence: 99%

Systematic review: the evidence base for long‐term management of coeliac disease

Haines

Anderson

Gibson

2008

Aliment Pharmacol Ther

182

144

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“…Vários estudos realizados na população adulta também observaram que a dieta sem glúten não restituiu totalmente a DMO 4,9,12,[18][19][20] .…”

Section: Discussionunclassified

“…A doença celíaca (DC) apresenta alta incidência de fraturas ósseas no esqueleto periférico 2,3 . Os adultos com DC apresentam risco aumentado para DMO reduzida [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] . Por outro lado, são poucos os dados acerca da DMO em crianças e adolescentes com DC [21][22][23][24][25][26][27][28][29] .…”

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Celiac disease under treatment: evaluation of bone mineral density

Carvalho¹,

Sdepanian²,

Neto³

et al. 2003

J Pediatr (Rio J)

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Objective: the present study was designed to compare the bone mineral density of children and adolescents with celiac disease to the bone mineral density of controls, and to evaluate laboratory analysis of calcium metabolism of celiac disease patients.Methods: thirty celiac disease patients (17 children, 13 adolescents), on a gluten-free diet, and 23 healthy subjects were studied. Tests of bone mineral density of the lumbar spine (DEXA, Lunar) were performed in all patients and controls. Laboratory analysis of calcium metabolism was performed in all patients.Results: mean weight and height of adolescents with celiac disease were lower than mean weight and height of controls (p<0.05). Bone mineral density in adolescents with celiac disease was significantly reduced if compared to controls (p=0.015), whereas no significant difference was found among children with celiac disease and controls. The number of adolescents who had started a glutenfree diet after the age of 2 years was higher than in children (p=0.003). Serum levels of ionized calcium, total calcium and parathormone were normal.Conclusions: the one mineral density of adolescents with celiac disease was lower than controls; whereas, no difference was found between the bone mineral density of children with celiac disease and controls.J Pediatr (Rio J) 2003;79(4):303-8: celiac disease, diet therapy, bone density, child, adolescent. ResumoObjetivo: comparar a densidade mineral óssea de crianças e adolescentes com doença celíaca em tratamento com controles sadios, e avaliar exames laboratoriais relacionados com o metabolismo do cálcio.Métodos: foram estudados 30 pacientes com doença celíaca em dieta isenta de glúten, 17 crianças e 13 adolescentes, e 23 indivíduos saudáveis. Todos os pacientes e controles realizaram a densidade mineral óssea (DEXA, Lunar). Os pacientes realizaram dosagem sérica de cálcio total, cálcio ionizado, fósforo, magnésio, fosfatase alcalina e paratormônio.Resultados: a média de peso, estatura e densidade mineral óssea dos adolescentes com doença celíaca foi menor do que dos controles (p<0,05), enquanto que não se observaram diferenças estatisticamente significantes destes parâmetros, comparando as crianças com doença celíaca com os controles. A proporção de adolescentes que iniciou dieta isenta de glúten após os dois anos de idade foi maior do que a de crianças (p<0,05). Os pacientes apresentaram níveis séricos normais de cálcio ionizado, cálcio total e paratormônio.Conclusões: a densidade mineral óssea dos adolescentes com doença celíaca em dieta isenta de glúten foi menor do que dos controles. Por outro lado, não houve diferença entre a densidade mineral óssea de crianças com doença celíaca e controles.J Pediatr (Rio J) 2003;79(4):303-8: doença celíaca, dietoterapia, densidade óssea, criança, adolescente.

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Effect of a gluten free diet on osteopenia in adults with newly diagnosed coeliac disease.

Cited by 110 publications

References 13 publications

Bone Mineral Density and Importance of a Gluten-Free Diet in Patients With Celiac Disease in Childhood

Bone Mineral Density and Importance of a Gluten-Free Diet in Patients With Celiac Disease in Childhood

Systematic review: the evidence base for long‐term management of coeliac disease

Celiac disease under treatment: evaluation of bone mineral density

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