Effect of a glyphosate-based herbicide in Cyprinus carpio: Assessment of acetylcholinesterase activity, hematological responses and serum biochemical parameters

Glyphosate-based herbicide affects biochemical parameters in Rhamdia quelen (Quoy & Gaimard, 1824 and) Leporinus obtusidens (Valenciennes, 1837)

“…In this context, they appear to be reliable in demonstrating liver damage caused by pesticides (Gholami-Seyedkolaei et al, 2013). In the present study, the plasma transaminases results showed liver damage under glyphosate exposure.…”

“…The liver damage was evidenced through some laboratory studies by Crestani et al (2006) who observed increased transaminase when R. quelen were exposure to clomazone (0.5 or 1.0 mg/L). Other authors have demonstrated increased AST and ALT activity when Cyprinus carpio were exposed to glyphosate at 3.5, 7, and 14 mg/L (Gholami-Seyedkolaei et al, 2013). An increase in these enzymatic activities (ALT and AST) in the extracellular fluid or plasma may be a sensible indicator of cellular liver damage caused by glyphosate exposure.…”

Altered Hematological and Biochemical Parameters in Schoolchildren Living in an Agricultural Community of Merida State, Venezuela

“…Various studies on animal models exposed to specific pesticides have explored changes in hematological and biochemical parameters as possible biomarkers of pesticide exposure before adverse clinical health problems occur [24][25][26][27][28][29]. More recently, clinical studies on pesticide sprayers have focused on the immunological, hematological and biochemical statuses of these farmers [23,[67][68][69][70][71].…”

“…Ismail et al [23] revealed significant differences in hematological, renal and hepatic indices in children and adolescent pesticide applicators compared with control group. Aside from these parameters, various studies evaluated the variation in oxidant/antioxidant status in experimental animals [24][25][26] as well as in aquatic organisms [27][28][29] to monitor the effects of chronic exposure to OP and phosphonate pesticides. Many pesticides share common cytotoxic mechanisms involving mitochondrial dysfunction, Altered Hematological and Biochemical Parameters in Schoolchildren Living in an Agricultural Community of Merida State, Venezuela which causes the generation of reactive oxygen species (ROS) and dysregulation of the oxidant/antioxidant system, thereby leading to oxidative stress [30,31].…”

Immunobiochemical modulations caused by clomazone in Swiss albino mice

“…Increases in the contents of liver enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) may be a sensible indicator of cellular liver damage caused by pesticide exposure (Gholami-Seyedkolaei, Mirvaghefi, Farahmand, & Kosari, 2013). Sharma, Bashir, Rshad, Gupta, and Dogra (2005) reported a significant increase in AST, ALT, and ALP activities in pesticide-treated rats that may be due to increase in the secretory activities of the hepatocyte cells resulted from the disturbance in their transport function and membrane permeability as a result of pesticide-induced hepatic injury that causes the leakage of AST, ALT, and ALP from hepatocytes into the blood (Abdulaziz & Hristev, 1996;Fan et al, 2009;Murussi et al, 2016;Yousef, Abbassi, & Yacout, 1999).…”