Effect of a gold salt on the immune response

Persellin, Robert H.; Hess, Evelyn V.; Ziff, Morris

doi:10.1002/art.1780100204

Cited by 52 publications

(18 citation statements)

References 22 publications

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“…These data are in agreement with those obtained in the in vivo studies which indicate that GST inhibits activities of lysosomal enzymes [22,23] but not their release [24,25].…”

Section: Discussionsupporting

confidence: 94%

Effects ofd-penicillamine, dichlofenac sodium and gold sodium thiomalate upon the selective release of lysosomal enzymes from human polymorphonuclear leucocytes to immune complex

Carević¹

1985

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The selective release of beta-glucuronidase (beta-Gluc) and beta-N-acetylglucosaminidase (beta-Glm) from human polymorphonuclear leucocytes (PMN), initiated with bovine serum albumin/anti-bovine serum albumin (BSA/anti-BSA) immune complex (15 micrograms/ml-1) was significantly reduced by increasing concentrations (10(-7) M, 10(-6) M and 10(-5) M) of D-penicillamine (D-PEN) in a dose-dependent fashion. These effects upon the exocytosis of the lysosomal enzymes studied are in accordance with the results obtained previously in rats with adjuvant arthritis. In contrast, Dichlofenac Sodium (DICHL), which has been found to exert inhibitory activity upon extracellular release of beta-Gluc and beta-Glm in adjuvant arthritic rats in previous studies, had no significant in vitro effect on the exocytosis of these enzymes at the concentrations identical to those of D-PEN. Also, Gold Sodium Thiomalate (GST), in the same concentrations ranging from 10(-7) M-10(-5) M, failed to inhibit selective release of beta-Gluc and beta-Glm in the present investigations. Additionally, BSA/anti-BSA, D-PEN, DICHL and GST did not significantly produce the extracellular release of lactate dehydrogenase (LDH) indicating that under experimental conditions described the cell remained intact. Moreover, neither D-PEN, DICHL, GST or BSA/anti-BSA significantly changed the activities of lysosomal enzyme markers used in these experiments. The possible mechanism(s) of the observed phenomena are discussed.

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“…These data are in agreement with those obtained in the in vivo studies which indicate that GST inhibits activities of lysosomal enzymes [22,23] but not their release [24,25].…”

Section: Discussionsupporting

confidence: 94%

Effects ofd-penicillamine, dichlofenac sodium and gold sodium thiomalate upon the selective release of lysosomal enzymes from human polymorphonuclear leucocytes to immune complex

Carević¹

1985

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“…This finding recalls the observations of Persellin, Hess, and Ziff (1967), who found that gold salts had no effect on the antibody response to a variety of antigens. The value of this test in the diagnosis and prediction of gold toxicity is discussed.…”

Section: Criteria For Positive Lymphocyte Transformationsupporting

confidence: 90%

The lymphocyte transformation test and gold hypersensitivity.

Denman¹,

Denman²

1968

Annals of the Rheumatic Diseases

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“…Sodium aurothiomalate has recently been shown to inactivate C1 but does not otherwise appear to alter immunologic function (26,27). Antimalarials inhibited L-cell lysis by cytotoxins; inhibited RNA, DNA, and protein synthesis by cells; inhibited DNA and RNA polymerase; and bound to dsDNA (25,28,29).…”

Section: Discussionmentioning

confidence: 99%

Effects of certain antirheumatic drugs on normal human peripheral blood lymphocytes. Inhibition of mitogen‐ and antigen‐stimulated incorporation of tritiated thymidine

Panush

1976

Arthritis & Rheumatism

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The effects of antirheumatic drugs on in vitro responses of normal human peripheral blood lymphocytes were examined and found to affect phytomitogen, antigen, and mixed lymphocyte responses. The drugs and concentrations (pg/ml) at which 50% inhibition (ID50) of phytomitogen stimulation occurred were acetylsalicylic acid, 80; phenylbutazone, 150; indomethacin, 250; sodium aurothiomalate, 200; hydroxychloroquine, 75; D-penicillamine, 400; hydrocortisone, 50; naproxen, 350; and sodium meclofenamate, 175. Acetaminophen enhanced blastogenesis by 100% at 200 pg/ml, but was 50% inhibitory at 500 pg/ml. Other drugs had no effects. Numbers of viable cells in cultures with and without mitogens and drugs were generally similar at beginnings and ends of experiments. Stimulated cell cultures containing combinations of drugs exhibited greater inhibition than did cultures of individual drugs. Inhibition by drugs was greater when cells were cultured in medium alone than in medium

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Effect of a gold salt on the immune response

Cited by 52 publications

References 22 publications

Effects ofd-penicillamine, dichlofenac sodium and gold sodium thiomalate upon the selective release of lysosomal enzymes from human polymorphonuclear leucocytes to immune complex

Effects ofd-penicillamine, dichlofenac sodium and gold sodium thiomalate upon the selective release of lysosomal enzymes from human polymorphonuclear leucocytes to immune complex

The lymphocyte transformation test and gold hypersensitivity.

Effects of certain antirheumatic drugs on normal human peripheral blood lymphocytes. Inhibition of mitogen‐ and antigen‐stimulated incorporation of tritiated thymidine

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