Effect of a herbomineral preparation D-400 in streptozotocin-induced diabetic rats

Mitra, Sophie; Gopumadhavan, S; Muralidhar, T. S.; Anturlikar, S. D.; Sujatha, M B

doi:10.1016/0378-8741(96)01439-0

Cited by 53 publications

(34 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…dissolved in freshly prepared 0.05 M of sodium citrate buffer, pH=4.6 [18]. Fasting rats must measure their normal blood glucose level before STZ injection (zero-time), then measured again after 48 hr of STZ injection to be sure that the rats became diabetic, their weight also must be determined before and after injection.…”

Section: Induction Of Diabetesmentioning

confidence: 99%

Cytological and Histochemical Studies in Rat Liver and Pancreas during Progression of Streptozotocin Induced Diabetes and Possible Protection of Certain Natural Antioxidants

Waer¹,

Helmy²

2017

J Nutr Food Sci

View full text Add to dashboard Cite

Background: Diabetes mellitus is a major endocrine disorder and growing health problem in most countries. Diabetes manifested by experimental animal models exhibit high oxidative stress due to persistent and chronic hyperglycemia which increases the generation of free radicals, Streptozotocin (STZ) provides an animal model of type 1 diabetes. Thereby depleting the activities of antioxidative defense systems with alteration of antioxidant activities of enzymes such as green tea and curcumin.

show abstract

Section: Induction Of Diabetesmentioning

confidence: 99%

Cytological and Histochemical Studies in Rat Liver and Pancreas during Progression of Streptozotocin Induced Diabetes and Possible Protection of Certain Natural Antioxidants

Waer¹,

Helmy²

2017

J Nutr Food Sci

View full text Add to dashboard Cite

show abstract

“…It is a traditional medicinal plant, with reported use as a remedy for diabetes mellitus, stomachic and diuretic problems. The plant extracts are also used in folk, ayurvedic and homeopathic systems of medicine [3]. The extract of G. sylvestre plays a major role in blood glucose homeostasis through increased serum insulin level via β-cells regeneration of the endocrine pancreas [4,5].…”

Section: Introductionmentioning

confidence: 99%

HPTLC/HPLC and gravimetric methodology for the identification and quantification of gymnemic acid fromGymnema sylvestremethanolic extracts

Ahmed¹,

Rao²,

Rao³

et al. 2013

Acta Chromatographica

View full text Add to dashboard Cite

Summary. Gymnemic acid (GA), a well known anti-diabetic compound has been detected in methanol extracts of intact leaves and in vitro callus cultures derived from leaf explants of Gymnema sylvestre. Callus biomass was developed in MS medium with optimum plant growth regulators (OPGRs) of 2,4-D (1.5 mg L −1 ) + KN (0.5 mg L −1 ) under abiotic stress conditions at 45 days determined by growth curve analysis. GA detection and quantification were carried out using thin-layer chromatography (TLC), highperformance thin-layer chromatography (HPTLC), high-performance liquid chromatography (HPLC), and gravimetric techniques. GA detection peak area and their absorption spectra were evaluated through HPTLC and HPLC with the standard GA. Quantification of GA had showed the linearity, accuracy, robustness and precision by HPLC. GA content was significantly higher in gravimetric method than HPLC. All these methods were found to be simple, accurate, selective and rapid and could be successfully applied for the determination of GA. It could have potential as a pharmaceutical drug for Type 1 diabetes mellitus (IDDM) and obesity.

show abstract

“…Despite the presence of known antidiabetic medicine in the pharmaceutical market, diabetes and the related complications continued to be a major medical problem. Recently, some medicinal plants have been reported to be useful in diabetes worldwide and have been used empirically as antidiabetic and antihyperlipidemic remedies (Mitra et al, 1996;Shukla et al, 2000;Bhattaram et al, 2002;Mahomed and Ojewole, 2003;Hou et al, 2005;Huang et al, 2005). Diabetes mellitus is known to cause hyperlipidemia through various metabolic derangements.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Hyypoglycemic and Hypolipidemic Activity of <i>Nyctanthes Arbortristis Linn</i> against Streptozotocin Induced Diabetic Rats

Rongwu¹

2012

American Journal of Pharmacology and Toxicology

View full text Add to dashboard Cite

Problem statement: The present study was aimed to explore the hypoglycemic and hypolipidemic activity of Nyctanthes arbortristis linn roots against Streptozotocin (STZ) induced experimental rats. Approach: Ethanolic extract of roots of Nyctanthes arbortristis was administered to streptozotocin induced rats.Glibenclamide was used as a standard drug. Blood glucose levels were determined after oral administration of a dose of Nyctanthes arbortristis (200 mg kggroups. Blood glucose levels were determined on 0, 7th, 14th, 21st and 28th day after oral administration of ethanolic extracts of Nyctanthes arbortristis (200 mg kg −1 ). Results: An ethanolic extract of Nyctanthes arbortristis was found to reduce blood sugar in streptozotocin induced diabetic rats. Reduction in blood sugar could be seen from 7th day after continuous administration of the extract. The effect of extracts of Nyctanthes arbortristis on serum lipid profile like Total Cholesterol, triglycerides, low density, very low density and high density lipoprotein were also measured in the diabetic and non diabetic rats. There was significant reduction in Total Cholesterol, LDL cholesterol, VLDL cholesterol and improvement in HDL cholesterol in diabetic rats. Conclusion: We concluded that Nyctanthes arbortristis possesses a hypoglycemic and hypolipidemic effect.

show abstract

Effect of a herbomineral preparation D-400 in streptozotocin-induced diabetic rats

Cited by 53 publications

References 10 publications

Cytological and Histochemical Studies in Rat Liver and Pancreas during Progression of Streptozotocin Induced Diabetes and Possible Protection of Certain Natural Antioxidants

Cytological and Histochemical Studies in Rat Liver and Pancreas during Progression of Streptozotocin Induced Diabetes and Possible Protection of Certain Natural Antioxidants

HPTLC/HPLC and gravimetric methodology for the identification and quantification of gymnemic acid fromGymnema sylvestremethanolic extracts

Evaluation of Hyypoglycemic and Hypolipidemic Activity of <i>Nyctanthes Arbortristis Linn</i> against Streptozotocin Induced Diabetic Rats

Contact Info

Product

Resources

About