Effect of a high density formula on growth and safety in congenital heart disease infants

Taniguchi-Fukatsu, Akiko; Matsuoka, Mio; Amagai, Teruyoshi

doi:10.1016/j.eclnm.2010.10.002

Cited by 10 publications

(10 citation statements)

References 9 publications

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“…In the present study, Onodera's PNI score predicted postoperative outcomes in infants with cardiac anomalies preoperatively. It remains to be seen whether one can prevent adverse events by implement of nutrition care, such as providing a high-density formula, 20 to improve nutrition states. To our knowledge, this is first report to show that Onodera's PNI is feasible in infants.…”

Section: Discussionmentioning

confidence: 99%

Nutrition Assessment as a Predictor of Clinical Outcomes for Infants With Cardiac Surgery: Using the Prognostic Nutritional Index

2011

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Section: Discussionmentioning

confidence: 99%

Nutrition Assessment as a Predictor of Clinical Outcomes for Infants With Cardiac Surgery: Using the Prognostic Nutritional Index

2011

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“…The complexity of this group of patients often causes insecurity when beginning the diet and also frequent interruptions in feeding, which will contribute to a lower energy supply . The use of energy‐enriched infant formula (EE formula) may promote a higher energy supply and was already proven to be safe and beneficial in this group of patients before CHD surgery . During the postoperative period, the use of EE formula was demonstrated to be well tolerated and was able to promote higher nutrition intake during the first postoperative days .…”

Section: Introductionmentioning

confidence: 99%

“…6 The use of energy-enriched infant formula (EE formula) may promote a higher energy supply and was already proven to be safe and beneficial in this group of patients before CHD surgery. 7 During the postoperative period, the use of EE formula was demonstrated to be well tolerated and was able to promote higher nutrition intake during the first postoperative days. 8 Although potentially beneficial, the use of EE formula still brings doubts regarding its safety, and there is lack of evidence regarding long-term effects.…”

Section: Introductionmentioning

confidence: 99%

Tolerability and Effects of the Use of Energy‐Enriched Infant Formula After Congenital Heart Surgery: A Randomized Controlled Trial

Scheeffer

Ricachinevsky

Freitas

et al. 2019

J Parenter Enteral Nutr

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Background Undernutrition is a common problem among children with congenital heart disease (CHD) and may lead to poorer surgical outcomes. A higher intake of energy during the postoperative period of CHD surgery seems to be associated with better outcomes. This study aimed to investigate the effect of the use of energy‐enriched formula (EE‐formula) compared with normocaloric formula during 30 days after CHD surgery. Methods A randomized controlled trial with patients undergoing heart surgery in a tertiary hospital in southern Brazil from March 2017 to December 2017 was performed. The intervention group received EE‐formula (1 kcal/mL), and the control group received normocaloric formula (0.67 kcal/mL). The researcher in charge of anthropometric evaluation was blinded to the randomization. Results Fifty‐nine patients were included; 30 in control group and 29 in intervention group. There were no statistically significant differences between groups regarding age, gender, anthropometry, and surgical risk classification after randomization. A statistically significant difference in z‐score of weight for age and in weight gain variation rate between groups after intervention was observed. Antibiotic use was less frequent in the intervention group, and hospital length of stay was shorter. General gastrointestinal side effects were similar between groups, whereas diarrhea was more frequent in the intervention group. However, this side effect was limited and had spontaneous resolution in 4 out of 6 cases. Conclusion This study demonstrates that EE‐formula use after heart surgery of patients with CHD is well tolerated and may improve short‐term nutrition outcome, decrease hospital stay, and reduce antibiotic use.

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“…Food concentrates reduce water intake without reducing the nutrient supply, whereas additional supplements that increase nutrient intake can increase energy density. Several clinical studies (Pillo‐Blocka et al, ; Taniguchi‐Fukatsu et al, ) were designed to explore the effects of feeding a high‐energy formula (HF) to infants with CHD. The results from these studies showed that feeding HF increased calorie intake, with fewer side effects on cardiopulmonary function.…”

Section: Introductionmentioning

confidence: 99%

High‐energy nutrition in paediatric cardiac critical care patients: a randomized controlled trial

Zhang

et al. 2018

Nursing in Critical Care

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Background Previous studies have shown that feeding a high‐energy formula (HF) to infants after cardiac surgery increases energy intake, with fewer side effects on cardiopulmonary function. However, impacts on weight gain and gastrointestinal function remain unclear. Aims and objectives To determine the impact of HF compared with standard formula on weight gain and gastrointestinal tolerance in postoperative infants with congenital heart disease. Design This was a randomized controlled trial. Methods The setting of the study was at a 20‐bed cardiac intensive care unit at a tertiary children's hospital in China. Study population included infants <1 year of age who underwent cardiac surgery and were allocated to the intervention group (n = 32) or control group (n = 32). The intervention group received HF (100 kcal/100 mL), and the control group received standard formula (67 kcal/100 mL) for 7 days during the stabilized postoperative period at the cardiac intensive care unit. Primary outcomes were weight gain and gastrointestinal intolerance. Secondary outcomes were energy intake and standard intensive care characteristics. Results Infants who received HF (n = 30) showed less weight loss than those who received standard formula (n = 29); −16 g [95% confidence interval (CI): −74 to 42] versus −181 g (95% CI: −264 to −99), P = 0·001. The evaluation of gastrointestinal intolerance showed that the intervention group had several side effects, such as abdominal distension (n = 1), gastric retention (n = 2) and diarrhoea (n = 1), while the control group had no problems. Enteral energy intake in the intervention group was higher than the control group from day three. Conclusion Infants after cardiac surgery fed with HF gained more weight but had increased feeding intolerance. However, the feeding intolerance symptoms could be relieved by medication and did not affect feeding advancement. Relevance to clinical practice Paediatric intensive care clinicians should consider gradually increasing the energy density of the formula during feeding and assess feeding intolerance signs in some children with malnutrition after cardiac surgery.

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Effect of a high density formula on growth and safety in congenital heart disease infants

Cited by 10 publications

References 9 publications

Nutrition Assessment as a Predictor of Clinical Outcomes for Infants With Cardiac Surgery: Using the Prognostic Nutritional Index

Nutrition Assessment as a Predictor of Clinical Outcomes for Infants With Cardiac Surgery: Using the Prognostic Nutritional Index

Tolerability and Effects of the Use of Energy‐Enriched Infant Formula After Congenital Heart Surgery: A Randomized Controlled Trial

High‐energy nutrition in paediatric cardiac critical care patients: a randomized controlled trial

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