Effect of a high-fat diet on obese-hyperglycaemic and non-obese Bar Harbor mice

Lemonnier, Daniel; Winand, Jacques; Furnelle, Jacques; Christophe, Jean

doi:10.1007/bf01219466

Cited by 34 publications

(23 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The percentages of the substrate fatty acids, palmitic acid and stearic acid (Paulsrud et al, 1970), and the products palmitoleic acid and oleic acid in the total liver lipids are shown in Table 3. The high concentration of oleic acid in the liver lipids from obese mice was similar to that reported previously (Lemonnier et al, 1971;Enser, 1975). Over all the treatment groups differences in desaturase activity corresponded to differences in the proportion of oleic acid and corresponded inversely with the proportion of stearic acid.…”

Section: Food Intake and Body Weight Of Micesupporting

confidence: 66%

The role of insulin in the regulation of stearic acid desaturase activity in liver and adipose tissue from obese–hyperglycaemic (ob/ob) and lean mice

Enser¹

1979

Biochemical Journal

View full text Add to dashboard Cite

The relationship between the hyperinsulinaemia of obese-hyperglycaemic (ob/ob) mice and their high activity of stearic acid A9-desaturase compared with lean mice has been investigated. The concentrations of plasma insulin in obese mice were decreased by 71, 88 and 96 % after treatment either with alloxan or food restriction to maintain the same weight as lean mice, or treatment of the weight restricted mice with alloxan followed by feeding ad libitum. The concentration of plasma insulin produced by the latter treatment was the same as in normal lean mice. After treatment the hepatic desaturase activities were 24, 68 and 19 % less respectively on a cell basis than in livers from untreated obese mice, and the total epididymal fat-pad activities were lower by 16, 62 and 57%. These results suggest that hyperinsulinaemia is not essential for the increased hepatic desaturase, but may be important in adipose tissue. Food intake appears to be a significant factor controlling the hepatic desaturase activity, but even this may be subject to overriding regulation by the concentration of esterified linoleic acid in the liver lipids, which was negatively correlated (r = 0.91, P<0.001) with desaturase activity.

show abstract

Section: Food Intake and Body Weight Of Micesupporting

confidence: 66%

The role of insulin in the regulation of stearic acid desaturase activity in liver and adipose tissue from obese–hyperglycaemic (ob/ob) and lean mice

Enser¹

1979

Biochemical Journal

View full text Add to dashboard Cite

show abstract

“…This hyperinsulinism is partly related to a high carbohydrate intake [l]. Long term feeding of a high fat diet to genetically obese obob mice (a) markedly increases their obesity, (b) has no effect on their hyperglycemia, but (c) decreases serum insulin levels [2]. Moreover, obesity can be induced in lean animals by feeding a high-fat-low-carbohydrate diet given ad lib.…”

Section: Metabolism Of Genetically Obese Rats On Normal or High-fat Dietmentioning

confidence: 99%

Metabolism of genetically obese rats on normal or high-fat diet

et al. 1974

Self Cite

View full text Add to dashboard Cite

Adult genetically obese fafa rats showed a high level of lipogenesis from glucose in liver but not in adipose tissue; pancreatic content and serum levels of insulin were elevated. Glucose uptake anO insulin sensitivity were decreased in muscle, fafa rats and their lean littermates fed a high-fat diet showed increased fat deposits. Serum insulin levels were not significantly affected by diet in either group. The larger the fat cells were, the more actively they utilised glucose; insulin sensitivity was influenced both by diet and cell size. Control rats made obese by a high caloric diet did not show insulin resistance in muscle. --The data indicate that in adult obesity in these rats, even in the presence of marked hyperinsulinism, increased lipogenesis in adipose tissue is not a prerequisite. Rather, fat storage is a consequence of increased uptake of circulating triglycerides. On a diet rich in carbohydrate, adipose tissue fatty acids were mainly of hepatic origin; on a high-fat diet they were of dietary origin.

show abstract

“…This fat does not present any detectable modification in the number of fat cells in genetic (3)(4)(5)(6)(7), hypothalamic (8,9), or nutritional (10) obesities in rats or mice, although obesity appears during the normal phase of fat cell multiplication. Yet, there may be an increased number of fat cells in other sites (7).…”

Section: Introductionmentioning

confidence: 99%

Effect of age, sex, and site on the cellularity of the adipose tissue in mice and rats rendered obese by a high-fat diet

Lemonnier¹

1972

J. Clin. Invest.

302

135

View full text Add to dashboard Cite

A B S T R A C T Cell size and number of parametrial fat pads were determined in Swiss mice made obese by means of a high-fat diet (40% lard w/w) given ad lib.This diet and a control were introduced to two groups of mothers during gestation and lactation, and sucklings were given the same diets as their mothers at weaning and throughout life.2-wk old mice suckled by mothers fed a high-fat diet have fatter parametrial pads. This difference is due solely to an increase in fat cell size. After weaning, until the 18th wk, the two groups differed with a striking fat cell enlargement seen in the obese group. Later on, whereas cell numbers did not change in the control group, a constant and uninterrupted increase in number is shown in those of obese mice until the 52nd wk. Hyperplasia was observed only in adults. When the highfat diet was introduced to adult rats it also triggered an increase in fat cell number.Three sites of fat pads were compared in both sexes at 32 wk of age. All sites increased in weight in the high-fat fed group. This was due to: hyperplasia in perirenal site, hypertrophy in epididymal and subcutaneous sites, and hyperplasia plus hypertrophy in the parametrial one. So, in each sex, adipose sites in the obese mice reacted to the diet in a site-specific way. It was concluded that the level of fat in a diet is involved in both formation and maturation of new fat cells and in the regulation of fat cell lipid content. The two processes may be separated or may act together according to the adipose tissue site.

show abstract

Effect of a high-fat diet on obese-hyperglycaemic and non-obese Bar Harbor mice

Cited by 34 publications

References 21 publications

The role of insulin in the regulation of stearic acid desaturase activity in liver and adipose tissue from obese–hyperglycaemic (ob/ob) and lean mice

The role of insulin in the regulation of stearic acid desaturase activity in liver and adipose tissue from obese–hyperglycaemic (ob/ob) and lean mice

Metabolism of genetically obese rats on normal or high-fat diet

Effect of age, sex, and site on the cellularity of the adipose tissue in mice and rats rendered obese by a high-fat diet

Contact Info

Product

Resources

About