Effect of a high monounsaturated fatty acids diet and a Mediterranean diet on serum lipids and insulin sensitivity in adults with mild abdominal obesity

Bos, M.; Vries, J.H.M. de; Feskens, Edith J. M.; Dijk, Susan J. van; Hoelen, Dianne W M; Siebelink, Els; Heijligenberg, Rik; Groot, Lisette C. P. G. M. de

doi:10.1016/j.numecd.2009.05.008

Cited by 110 publications

(117 citation statements)

References 29 publications

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“…Notably, 4 SFAs [14:0 (myristic acid), 16:0 (palmitic acid), 18:0 (stearic acid), and 22:0 (behenic acid)] and 2 MUFAs [16:1 (palmitoleic acid), 18:1n-9c (oleic acid)] were elevated by the high selenium intake. A previous report showed a positive correlation between SFAs and obesity (51), whereas MUFAs could reduce TGs with high glucose and low fat intakes (52). However, previous research has suggested that long-chain MUFAs actually contributed to the development of obesity (53).…”

Section: Discussionmentioning

confidence: 95%

High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs

Zhao

Barcus

Kim

et al. 2016

The Journal of Nutrition

106

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Section: Discussionmentioning

confidence: 95%

High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs

Zhao

Barcus

Kim

et al. 2016

The Journal of Nutrition

106

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“…This reported an improvement in insulin sensitivity when SFA, mainly derived from animal fats and lard, were replaced by MUFA in the diet but the difference between treatments was of borderline significance. The RISCK study (30) found no evidence for adverse effects of SFA on insulin sensitivity nor did the LIPGENE (31) study or the study by Bos et al (55) The current evidence suggests that there is probably no difference between SFA and MUFA on insulin resistance in human subjects.…”

Section: Insulin Resistancementioning

confidence: 48%

Reappraisal of SFA and cardiovascular risk

Sanders

2013

Proc. Nutr. Soc.

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This review reappraises dietary advice to reduce and replace SFA for the prevention of CVD. In the 1970s, SFA accounted for about 18% UK food energy, by 2001 it had fallen to 13% and continues to be above the <11% target. Compared with carbohydrates, C 12 -C 16 SFA raise serum total cholesterol (TC), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) without affecting the TC:HDL-C ratio; other SFA have neutral effects on the fasting lipid profile. Replacing 3% dietary SFA with MUFA or PUFA lowers LDL-C by 2% and TC:HDL-C ratio by 0·03. No other specific adverse effects of SFA compared with MUFA on risk CVD factors have been proven. Meta-analyses of prospective cohort studies report the relative risks (95% CI) of high v. low intakes of SFA to be 1·07 (0·96, 1·19) for CHD, 0·81 (0·62, 1·05) for stroke and 1·00 (0·89, 1·11) for CVD mortality and were not statistically significant. Exchanging 5% energy SFA for PUFA or carbohydrates found hazard ratios (95% CI) for CHD death to be 26% (−23, −3) and 4% (−18, 12; NS) lower, respectively. Meta-analysis of randomised controlled trials with clinical endpoints reports mean reductions (95% CI) of 14% (4, 23) in CHD incidence and 6% (−25, 4; NS) in mortality in trials, where SFA was lowered by decreasing and/or modifying dietary fat. In conclusion, SFA intakes are now close to guideline amounts and further reductions may only have a minor impact on CVD.

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“…It has been reported that their consumption can improve the lipid profile; a MUFA-rich diet was able to reduce total and LDL cholesterol in moderately obese humans and a n-6 PUFA-enriched diet produced a decrease in postprandial triacylglycerol compared with SFA-rich butter (Gardner and Kraemer, 2011;Bos et al, 2010;Masson and Mensink, 2011). The replacement of SFA with cis-MUFA improved the total/HDL cholesterol ratio and if the replacement was made with n-6 PUFA, postprandial tumor necrosis factor alpha (TNF-α) and interleukine 6 (IL-6) plasma levels were reduced in obese men (Egert et al, 2009).…”

Section: Postprandial Inflammatory Response To the Polyphenols Of Olimentioning

confidence: 99%

Cardiovascular risk protection from the Mediterranean diet and olive oil. A transcriptomic update in humans

2016

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SUMMARY: This review highlights the human studies that explore the benefits of the Mediterranean diet and olive oil, based on gene expression analysis. We summarized consistent human transcriptomic studies on cardiovascular risk, based on TMD and olive oil interventions, with real life doses and conditions. A literature review was carried out leading up to February 2016. The results show that the TMD, specially supplemented with virgin olive oil, produces beneficial changes in the transcriptomic response of relevant genes in cardiovascular risk such as CAT, GPX1 and SIRT2. p65 and MCP-1, IL1B, IL6, CXCL1, INF-γ, ARHGAP15 and IL7R, which are involved in inflammation; and ABCA1, SR-B1, PPARBP, PPARα, PPARγ, PPARδ, CD-36 and COX-1, which play an important role in cholesterol efflux. The available data illustrate a transcriptomic effect on atherosclerosis, inflammation and oxidative stress pathways as well as the mentioned genes.KEYWORDS: Cardiovascular; Mediterranean Diet; MUFA; Nutrigenomics; Olive oil; Polyphenols; Transcriptomics RESUMEN: Protección cardiovascular de la dieta mediterránea y el aceite de oliva. Una actua lización de transcriptómica en humanos. Esta revisión resume los estudios de transcriptómica en humanos que muestran efectos beneficiosos de la dieta mediterránea tradicional (TMD) y el aceite de oliva, en condiciones y dosis de la vida real en relación al riesgo cardiovascular. La revisión se llevó a cabo hasta febrero de 2016. Los resultados muestran que la TMD, especialmente suplementada con aceite de oliva virgen, ejerce cambios beneficiosos en la respuesta transcriptómica de genes relevantes en el riesgo cardiovascular tales como CAT, GPX1 y SIRT2. p65 y MCP-1, IL1B, IL6, CXCL1, INF-γ, ARHGAP15 y IL7R implicados en la inflamación. ABCA1, SR-B1, PPARBP, PPARα, PPARγ, PPARδ, CD-36 y la COX-1 juegan un papel importante en el eflujo de colesterol. Además, ADRB2 está relacionada con el estrés oxidativo. Los datos disponibles nos llevan a un efecto transcriptómico sobre las vías de arteriosclerosis, inflamación y estrés oxidativo, así como sobre los genes mencionados.

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Effect of a high monounsaturated fatty acids diet and a Mediterranean diet on serum lipids and insulin sensitivity in adults with mild abdominal obesity

Cited by 110 publications

References 29 publications

High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs

High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs

Reappraisal of SFA and cardiovascular risk

Cardiovascular risk protection from the Mediterranean diet and olive oil. A transcriptomic update in humans

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