EFFECT OF A <i>Lactobacillus</i> FERMENTATION PRODUCT ON GROWTH, IMMUNE RESPONSE AND FECAL ENZYME ACTIVITY IN WEANED PIGS

Lessard, Martin; Brisson, G. J.

doi:10.4141/cjas87-049

Cited by 53 publications

(23 citation statements)

References 20 publications

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“…Some studies reported that treatment of piglets with B. lactis increases blood leukocyte phagocytic and T-lymphocyte proliferative responses [75]. Similar results have been observed with gnotobiotic piglets, where feeding with L. acidophilus increases the white blood cells [61] and the antibody level [41].…”

Section: Immunomodulationsupporting

confidence: 74%

“…However, Li et al [41] did not observe any effect on the microflora collected from the digesta and faeces of piglets after 11 days of high dose ZnO supplementation. Moreover, Mores et al [50] registered an improvement of diarrhoea index in E. coli K85 infected pigs fed 2400 mg per kg zinc from different commercial sources of ZnO, but did not observe any reduction of faecal shedding of the strain used for the challenge.…”

Section: Protection Against Pathogensmentioning

confidence: 99%

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Alternatives to in-feed antibiotics in pigs: Evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa. A comparison of in vitro and in vivo results

et al. 2005

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-Weaned pigs are susceptible to frequent infectious diseases. Antibiotics have been used over decades to reduce pathogen infections, but many microorganisms are becoming resistant to antibiotics. Thus, there is an urgent need to find alternatives to in-feed antibiotics. Up to now, various compounds have been used as alternatives, giving promising but sometimes contrasting results. In recent years, the in vitro models of cell culture have been proposed for the screening of various compounds and understanding their mechanisms of action. The intestine is a complex system with a continuous cross-talk among epithelial cells, the local immune system and microflora. Alternatives to in-feed antibiotics may interact with any of these constituents. This review presents data on the protective effects of probiotics, zinc salts and organic acids, used as alternatives to in-feed antibiotics, against pathogen induced damage and inflammatory processes in the intestinal cells and the underlying mechanisms, with an attempt to compare in vitro and in vivo results. All the alternatives tested resulted in effective protection against pathogens by a series of interactions with intestinal cells and pathogens, including the inhibition of adhesion and invasion of pathogens, interference in signalling pathways induced by pathogenic bacteria, maintenance of the epithelial cell cytoskeleton and junctional structure and modulation of the host immune response. microorganismes sont devenus résistants à ces substances. Aussi, est-il urgent de trouver des alternatives aux antibiotiques additifs alimentaires. Jusqu'à présent, diverses alternatives ont été envisagées, certaines donnant des résultats prometteurs, d'autres des résultats variables. Au cours des dernières années, les modèles in vitro de cultures cellulaires ont été proposés pour cribler ces substances et élucider leurs mécanismes d'action. L'intestin est un système complexe faisant intervenir des communications permanentes entre les cellules épithéliales, le système immunitaire local et la microflore. Les alternatives aux antibiotiques peuvent interagir avec n'importe lequel de ces composants. Le présent article fait la synthèse des effets protecteurs et des mécanismes d'action des probiotiques, des sels de zinc et des acides organiques, utilisés comme alternatives aux antibiotiques dans les processus inflammatoires et les altérations cellulaires épithéliales in vitro, induites par des agents pathogènes. Elle tente de comparer ces résultats avec les observations in vivo. Toutes les alternatives évaluées ont été efficaces contre les agents pathogènes, via des mécanismes d'interaction cellules épithéliales-agents pathogènes. Ces mécanismes incluaient l'inhibition de l'adhésion et de l'invasion cellulaire par ces pathogènes, la modulation des mécanismes de signalisation intracellulaire induits par les bactéries pathogènes, le maintien de la structure du cytosquelette et des jonctions serrées des cellules épithéliales, et enfin la modulation des réponses immunitaires de la cellu...

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Section: Immunomodulationsupporting

confidence: 74%

Section: Protection Against Pathogensmentioning

confidence: 99%

Alternatives to in-feed antibiotics in pigs: Evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa. A comparison of in vitro and in vivo results

et al. 2005

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“…The same results showed [30] on the experiments with weaned piglets, used LFPLactobacillus-Fermentation-Product. This probiotic contents Lactobacillus bulgaricus, Lactobacillus casei, Streptococcus thermophilus, produced in Quebec, Canada.…”

Section: Physical -Chemical Characteristics Of the Probioticsupporting

confidence: 69%

Efficiency of Probiotics in Farm Animals

Delia¹,

Tafaj²,

Männer³

2012

Probiotic in Animals

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Section: Probioticsmentioning

confidence: 99%

“…They can elicit an increase in immunoglobulin a production (Perdigon et al, 1995) and stimulate macrophages and NK cells (natural killers cells; Chiang et al, 2000;Matsuzaki and Chin, 2000). They can also regulate anti-and pro-inflammatory cytokine production (Lessard and Brisson, 1987;Shu et al, 2001;Roselli et al, 2005).The effect of probiotics depends on the combination of selected bacterial genera (Table 2), their doses, and on the interactions of probiotics with some pharmaceuticals, feed composition, storage conditions and feed technology (Kyriakis et al, 1999;Park et al, 2001; Chen et al, 2005). Probiotic application to piglets is important especially in the post-weaning period for the prophylaxis of PWD which is usually caused by enterotoxigenic E. coli strains (MantereAlhonen, 1995;Roberfroid, 1998; Bomba et al, 2002;Roselli et al, 2005;Marinho et al, 2007).…”

mentioning

confidence: 99%

Alternatives to antibiotic growth promoters in prevention of diarrhoea in weaned piglets: a review

Vondruskova¹,

Slamova²,

Trčková³

et al. 2010

Vet. Med.

165

155

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ABSTRACT:The weaning time is a crucial period in the management of piglets. The risk of development of post-weaning diarrhoea (PWD) in piglets is high. PWD is the cause of serious economic losses in pig herds. Since 2006, the use of antibiotic growth promoters for prevention of diarrhoeal diseases in piglets has been banned. This measure also led to the investigation of alternative suitable feed supplements that would be reasonably efficient in protecting and sustaining animal health and performance. Various natural materials such as probiotics, prebiotics, organic acids, zinc and plant extracts have been tested as effective alternatives to antibiotics. Recently, owing to their high adsorption capacity, research efforts have been conducted on the application of natural clays and clay-based feed supplements. The purpose of this review is to summarize the effect of different alternative components as growth promoters on the health and performance of weaned and growing piglets.Keywords: infection; swine; antibiotics; intestinal microflora; performance; probiotics; prebiotics, organic acids; zinc; phytobiotics; aluminosilicate List of abbreviations CFU = colony-forming unit; ETEC = enterotoxigenic Escherichia coli; MMT = montmorillonite; PWD = post weaning diarrhoea; SCFA = short chain fatty acids; VFA = volatile fatty acids Review ArticleVeterinarni Medicina, 55, 2010 (5): 199-224 200 ruses (Moller et al., 1998;Song et al., 2006), transmissive gastroenteritis virus (Hampson et al., 1987; Alexa et al., 1995 Alexa et al., , 2001 Chae et al., 2000;Madec et al., 2000;Melin et al., 2004;Song et al., 2006;Thomsson et al., 2008) and others have been most frequently diagnosed.Early-weaned piglets are exposed to several stress factors, with nutrition, etiology and indoor environment of housing being particularly implicated (Madec et al., 2000;Laine et al., 2008). Noninfectious stress factors which are involved in the development of gastroenteric disorders are: -age of piglets when they are weaned from their dam (Svensmark et al., 1989;Skirrow et al., 1997), -sudden change of feed from sow milk that provides piglets with immunoglobulins (Bailey et al., 1992), -irregular feed intake (Bark et al., 1986;Spencer and Howell, 1989;Svensmark et al., 1989;Madec et al., 1998;Laine et al., 2008), -feed structure (Amezcua et al., 2002), -animal hygiene and housing conditions (Le Dividich, 1981;Le Dividich and Herpin, 1994;Madec et al., 1998), -inadequate feeder space per piglet in the pen (Amezcua et al., 2002). Numerous changes in the early-weaned piglet body can initiate PWD, such as morphological (Hampson, 1986) and functional alterations of the small intestine (Kidder and Manners, 1980; Hampson and Kidder, 1986), changes in intestinal colonization with predominance of E. coli (Melin et al., 1997;Katouli et al., 1999) and weakening of the immune system (Blecha et al., 1983;Wattrang et al., 1998). Ban of antibiotic growth promotersRegarding the fact that weaning greatly affects general health condition of piglets, it is nece...

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EFFECT OF A Lactobacillus FERMENTATION PRODUCT ON GROWTH, IMMUNE RESPONSE AND FECAL ENZYME ACTIVITY IN WEANED PIGS

Cited by 53 publications

References 20 publications

Alternatives to in-feed antibiotics in pigs: Evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa. A comparison of in vitro and in vivo results

Alternatives to in-feed antibiotics in pigs: Evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa. A comparison of in vitro and in vivo results

Efficiency of Probiotics in Farm Animals

Alternatives to antibiotic growth promoters in prevention of diarrhoea in weaned piglets: a review

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