Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD Study

Jakicic, John M.; Jaramillo, Sarah A.; Balasubramanyam, Ashok; Bancroft, Barbara; Curtis, Jeffery M.; Mathews, Anne; Pereira, Mark A.; Regensteiner, Judith G.; Ribisl, Paul M.

doi:10.1038/ijo.2008.280

Cited by 132 publications

(134 citation statements)

References 17 publications

Supporting

Mentioning

129

Contrasting

Order By: Relevance

“…The majority of patients seem to enjoy the program and feel that it helped them lost weight and manage their disease ( Figure 3F). Data from twenty longitudinal cohort studies and six large-scale diabetes prevention intervention trials in adults with impaired glucose tolerance or at high risk of cardiovascular disease unanimously reflected the beneficial effect of moderate physical activity (approximately 150 minutes per week) in reducing the risk of developing the T2DM by nearly 20-30% [23][24][25][26]. Substantial amelioration of risk (40-60%) is achieved in pre-diabetic patients however with rigorous lifestyle intervention counseling for physical activity, nutrition, and weight loss [24].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, the Copenhagen Type 2 Diabetes Rehabilitation Project [30]-a randomized control trial of a small population of patients with T2DM undergoing a rehabilitation program consisting of empowerment-based education, supervised exercise and dietary intervention -found similar reductions at 1-year in weight (2.2 vs 1.6 kg), waist circumference (2.0 vs 1.6 cm), HbA1c (0.2 vs 0.4%), sBP (6 vs 3 mmHg) and dBP (4 vs 3 mmg) between the rehabilitation group versus the individual outpatient primary care group, suggesting both models of care are of similar efficacy [31]. Larger seminal trials, however, such as the Look AHEAD trial [32], clearly showed early superiority of the intensive lifestyle intervention arm versus the conventional treatment arm, with the former group having lost >5% in more than 50% of patients despite a lack of clear cardiovascular benefit at 9.6-yrs of follow-up [22][23][24][25][26][27][28][29][30][31][32].…”

Section: Waist Circumference Weight Loss and Selfempowermentmentioning

confidence: 99%

See 1 more Smart Citation

Self-Empowerment and Health Outcomes in Obese Adults with Type 2 Diabetes Following Completion of a Multi-Disciplinary Metabolic Rehabilitation Program

RH¹

2017

EMIJ

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Waist Circumference Weight Loss and Selfempowermentmentioning

confidence: 99%

Self-Empowerment and Health Outcomes in Obese Adults with Type 2 Diabetes Following Completion of a Multi-Disciplinary Metabolic Rehabilitation Program

RH¹

2017

EMIJ

View full text Add to dashboard Cite

“…The Look AHEAD study showed greater improvements in cardiorespiratory fitness for men compared with women at both the 1-and 4-year followup, even with adjustment for baseline fitness levels. 243,261 In contrast, both women and men with T2DM appeared to have similar improvements in fitness in response to exercise training interventions in the Diabetes Aerobic and Resistance Exercise trial 253 and in a meta-analysis of physical activity interventions among people with T2DM.…”

mentioning

confidence: 99%

Sex Differences in the Cardiovascular Consequences of Diabetes Mellitus

et al. 2015

View full text Add to dashboard Cite

Currently, ≈1 in 13 people living in the United States has DM, and 90% to 95% of these individuals have type 2 DM (T2DM).2 Overall, the prevalence of T2DM is similar in women and men. In the United States, ≈12.6 million women (10.8%) and 13 million men (11.8%) ≥20 years of age are currently estimated to have T2DM. 2 Among individuals with T2DM, cardiovascular disease (CVD) is the leading cause of morbidity and mortality and accounts for >75% of hospitalizations and >50% of all deaths.3 Although nondiabetic women have fewer cardiovascular events than nondiabetic men of the same age, this advantage appears to be lost in the context of T2DM. 4,5 The reasons for this advantage are not entirely clear but are likely multifactorial with contributions from inherent physiological differences, including the impact of the sex hormones, differences in cardiovascular risk factors, and differences between the sexes in the diagnosis and treatment of DM and CVD. 6 In addition, there are racial and ethnic factors to consider because women of ethnic minority backgrounds have a higher prevalence of DM than non-Hispanic white (NHW) women.This scientific statement was designed to provide the current state of knowledge about sex differences in the cardiovascular consequences of DM, and it will identify areas that would benefit from further research because much is still unknown about sex differences in DM and CVD. Areas that are discussed include hormonal differences between the sexes and their possible effects on the interaction between DM and CVD, sex differences in epidemiology, ethnic and racial differences and risk factors for CVD in DM across the life span, sex differences in various types of CVD and heart failure, and sex differences in the effects of treatments for DM, including both medications and lifestyle. In addition, there is discussion about risk factors that are specific to women, including gestational diabetes mellitus (GDM) and polycystic ovarian syndrome (PCOS), which affect CVD risk. Table 1 focuses on sex differences in CVD risk factors and outcomes in DM, and Table 2 provides information about sex differences in CVD treatments and interventions in DM. Table 3 contains some of the important ideas for research in sex differences in the cardiovascular consequences of DM. The American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.This statement was approved by the American Heart Association Science Advisory and Coordinating Committee on July 31, 2015, and the American Heart Association Executive Committee on September 5, 2015. A copy of the document is available at http://my.americanheart.org/statements by selecting either the "By...

show abstract

“…Combined approaches described above are effective in reducing insulin resistance [82], and decreasing CVD, heart failure, stroke, cancer, diabetes, and all-cause mortality [83][84][85]. However, because of poor compliance, unwillingness to accept obesity as a disease, and associated social stigma [19], the overall effectiveness of therapies for weight loss and metabolic syndrome is imperfect.…”

Section: Overall Management Of Obesity and T2dmentioning

confidence: 99%

Preventing Long-Term Complications of Obesity, Type 2 Diabetes, and Metabolic Syndrome

Wimalawansa¹

2015

Endocrinol Metab Syndr

View full text Add to dashboard Cite

During the past three decades, obesity and type 2 diabetes have become major public health problems worldwide. Together, these two are the most costly non-communicable diseases affecting most countries. Compared to the escalating management costs associated with their complications, the day-to-day management cost of these two diseases are relatively small. In addition to better management of these to diseases, the key is to not only to prevent people becoming obese and developing type 2 diabetes, but also to prevent associated complications. While implementing mass-scale public education on healthy diet and physical activities (sustainable positive lifestyle changes) on one side, patient-oriented, individualized, cause-driven, preventative approaches are essential for reducing the morbidities and mortalities associated with these two common diseases. Blindly following the standardized care of one-treatment-fits-all model is not only ineffective but also cost more in the long run, comparison to the intensive, individualize care model in preventing long-term complications and reducing management costs.

show abstract

Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD Study

Cited by 132 publications

References 17 publications

Self-Empowerment and Health Outcomes in Obese Adults with Type 2 Diabetes Following Completion of a Multi-Disciplinary Metabolic Rehabilitation Program

Self-Empowerment and Health Outcomes in Obese Adults with Type 2 Diabetes Following Completion of a Multi-Disciplinary Metabolic Rehabilitation Program

Sex Differences in the Cardiovascular Consequences of Diabetes Mellitus

Preventing Long-Term Complications of Obesity, Type 2 Diabetes, and Metabolic Syndrome

Contact Info

Product

Resources

About