Effect of a miniaturized extracorporeal circulation (MECC™System) on liver function

Abstract

Liver function improved after cardiac surgery in both groups of patients, which may partly be explained by an increase in CI under mild inotrope support. Differences between the extracorporeal circuits with respect to PDRig appear to be minimal in a group of patients without pre-existing liver injury.

Minimized extracorporeal circulation system in coronary artery bypass surgery: a 10-year single-center experience with 2243 patients

“…A better liver function in MECC patients, especially in patients with liver diseases, was found by Prasser and colleagues [20].…”

Miniaturized cardiopulmonary bypass improves short-term outcome in cardiac surgery: A meta-analysis of randomized controlled studies

“…Specifically, we excluded 3 studies because of duplicate publication either explicitly acknowledged 10 or not 11,12 : 2 studies 13,14 because there were no outcome data and further details could not be obtained by the authors and 1 nonrandomized trial. 15 We finally identified 16 eligible randomized clinical trials, [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] which were included in the final analysis (Table 1).…”

The Inflammatory Response to Miniaturised Extracorporeal Circulation: A Review of the Literature

“…This is characterised by elevated liver transaminases and carries a mortality of up to 65% [32]. Prasser et al measured serum levels of alanine aminotransferase (ALT) and excretion of indocyanine green (a nontoxic dye metabolised solely by the liver) in 20 patients undergoing CABG and found no significant differences between MECC and CCPB groups [14]. With the aforementioned incidence of acute liver injury, it is unsurprising that this study was unable to demonstrate any difference in liver function between the two interventions.…”