Effect of a Mouthrinse Containing Calcium Lactate on the Formation and Mineralization of Dental Plaque

Hoeven, J.S. van der; Schaeken, M.J.M.; Creugers, T.J.

doi:10.1159/000261168

Cited by 10 publications

(4 citation statements)

References 16 publications

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“…In principle, the chemical properties of this interface can be altered to decrease the cariogenic challenge originating from the metabolism of the oral flora. Several agents have been advanced as constituents of mouthwashes to minimize enamel demineralization, for example, lactate dehydrogenase [Higham and Edgar, 1991], urea and fluoride [Pearce, 1982[Pearce, , 1984Pearce and Nelson, 1988;Pearce et al, 1991], calcium phosphate [Stralfors, 1964;Rankine et al, 1989], calcium lactate [van der Hoeven, 1985;Shrestha et al, 1982;van der Hoeven et al, 1989;Kashket and Yaskell, 1992], calcium glycerophosphate [Bowen, 1972;Grenby and Bull, 1975;Sidi and Wilson, 1991] …”

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confidence: 99%

Comparative Reduction of Enamel Demineralization by Calcium and Phosphate in vitro

Tanaka¹,

Kadoma

2000

Caries Res

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In theory, calcium and phosphate in the plaque fluid exert a large influence on the demineralization of enamel surface. In order to know the effect of increasing the concentration of either of these factors, the following in vitro experiment was conducted. Three thin sections, about 150 Ìm thick, were cut out from each of 13 human premolars. All surfaces of the sections, except for the original enamel surface, were coated with nail varnish. These sections were immersed into one of two sets of demineralizing solutions for 1 week at 25°C. Each set, the ‘calcium set’ and the ‘phosphate set’, contained three solutions. The composition of these solutions differed mainly in calcium or phosphate concentrations. After 1 week, the degree of demineralization was determined by image analysis of contact microradiograms from each section. The subsurface demineralization in enamel was reduced by 95% by increasing the calcium concentration of the demineralizing solution from 7 to 21 mmol/l. A similar reduction (87%) was observed by increasing the phosphate concentration. However, the amount of phosphate needed was approximately 20 times more than that of calcium. The larger inhibitory effect that calcium has on enamel demineralization was related to the larger effect it has on the degree of saturation of the solution. Even though no statistically significant difference was found between the effect of calcium and phosphate on the demineralization of enamel (when the solutions had the same degree of saturation), the difference in the standard deviation of demineralization suggests the existence of some other factors which have an influence on the demineralization reaction.

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confidence: 99%

Comparative Reduction of Enamel Demineralization by Calcium and Phosphate in vitro

Tanaka¹,

Kadoma

2000

Caries Res

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“…In testing the effects of mouthrinses containing calcium lactate on the levels of plaque calcium, reduced calculus deposition was observed in healthy volunteers [Schaeken and van der Hoeven, 1990], This was a rather unexpected finding, since approximately twofold in creased levels of calcium in dental plaque were observed even 16 h after rinses with calcium lactate [van der Hoeven et al, 1989;Schaeken and van der Hoeven, 1990]. The present experiment was undertaken to retest the antical culus properties of calcium lactate.…”

Section: Introductionmentioning

confidence: 77%

Control of Calculus Formation by a Dentifrice Containing Calcium Lactate

Schaeken¹,

Hoeven²

1993

Caries Res

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The aim of this study was to re-investigate the anticalculus effects of calcium lactate. To this end calcium lactate was incorporated into experimental toothpastes. Three groups of 20 human volunteers brushed their teeth at least twice daily with three different toothpastes: (1) one containing calcium lactate, (2) one containing calcium lactate plus sodium lauryl sulphate, and (3) a control toothpaste. Plaque accumulation, gingival bleeding and calculus formation were scored at the beginning and at the end of the 3-month experimental period. After the first clinical examination the dentition was professionally cleaned to remove all dental deposits. The use of the calcium lactate containing toothpastes had no significant effects on plaque accumulation and gingival bleeding. However, calculus scores were significantly reduced in the calcium lactate groups at the end of the experiment. The results confirm and extend previous findings that the topical use of calcium lactate reduces calculus formation by, as yet, unexplained mechanisms.

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“…A clue to its possible mode of action can be drawn from the work of Van der Hoeven et al (1989), who found that use of a 1 % calcium lactate mouthrinse 4 times a day failed to alter gross plaque accumulation, but did double plaque calcium and interestingly also phosphate levels after only one week's usage. A clue to its possible mode of action can be drawn from the work of Van der Hoeven et al (1989), who found that use of a 1 % calcium lactate mouthrinse 4 times a day failed to alter gross plaque accumulation, but did double plaque calcium and interestingly also phosphate levels after only one week's usage.…”

Section: Calcium Lactatementioning

confidence: 99%

Non-Fluoride Anticaries Agents

Forward¹

1994

Adv Dent Res.

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Many potential anticaries agents other than fluoride have been identified in a range of laboratory models. This review covers only those agents which have demonstrated significant activity in either animal caries models, in situ models, or human clinical trials, including those measuring plaque acid formation. The agents which so far have been identified can be divided into 5 categories: (1) phosphorus-containing agents, (2) calcium-containing agents, (3) antimicrobials and antibiotics, (4) metals, and (5) miscellaneous agents. Although many potential agents have been identified in various models, very few have been taken forward to full anticaries testing in humans. Chlorhexidine is an exception, and certain agents such as calcium glycerophosphate have been shown to result in greater anticaries activity when added to fluoride. In the future, non-fluoride agents which modify the production of acid in plaque--either antimicrobially, biochemically, or directly--appear to have the most promise for use in topical products and may prove to be effective anticaries systems. Phosphates have shown encouraging activity as diet additives.

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Effect of a Mouthrinse Containing Calcium Lactate on the Formation and Mineralization of Dental Plaque

Cited by 10 publications

References 16 publications

Comparative Reduction of Enamel Demineralization by Calcium and Phosphate in vitro

Comparative Reduction of Enamel Demineralization by Calcium and Phosphate in vitro

Control of Calculus Formation by a Dentifrice Containing Calcium Lactate

Non-Fluoride Anticaries Agents

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