Effect of a multinutrient supplement as an adjunct to nonsurgical treatment of periodontitis: A randomized placebo‐controlled clinical trial

Abstract

BackgroundThe aim of this double‐blind randomized placebo‐controlled clinical trial was to evaluate the efficacy of a multinutrient supplement as an add‐on therapy to scaling and root planing for patients with periodontitis.MethodsForty‐two patients with stage III or IV periodontitis were randomly allocated to a 2‐month treatment of either a multinutrient supplement containing vitamin C, vitamin E, zinc, selenium, alpha‐lipoic‐acid, cranberry extract, grapeseed extract, and coenzyme Q10 or placebo capsules as an adjunct to conservative periodontal therapy. Periodontal parameters, including probing pocket depth, gingival recession, bleeding on probing, approximal plaque index, and papillary bleeding index, were assessed. Clinical attachment loss, periodontal inflamed surface area, periodontal epithelial surface area, and percentages of pocket sites with ≤3, ≤4, ≥5, ≥6, ≥7, and ≥4 mm with bleeding on probing were calculated.ResultsAll clinical parameters significantly improved from baseline to reevaluation within each group (p < 0.05). Multinutrient intake resulted in a significantly higher reduction of probing‐pocket‐depth (−0.75 ± 0.42 mm) and bleeding‐on‐probing (−21.9 ± 16.1%) from baseline to reevaluation compared with placebo (−0.51 ± 0.30 mm, p = 0.040 and −12.5 ± 9.8%, p = 0.046, respectively). All periodontal parameters showed insignificantly higher improvements in patients receiving the supplement compared with those receiving the placebo (p > 0.05).ConclusionsMultinutrient supplementation as an adjunct to nonsurgical treatment of periodontitis showed some additional benefit regarding probing‐pocket‐depth and bleeding‐on‐probing. However, the clinical relevance needs to be further explored.

Associations of dietary antioxidant intake with periodontal health among US adults: An exploratory mediation analysis via mitochondrial function

“…Antioxidant supplementation could also confer benefits to periodontal health. A recent randomized controlled trial on multi-nutrient supplementation with antioxidant capability in conjunction with non-surgical treatment for periodontitis demonstrated additional advantages regarding PPD and bleeding on probing (Laky et al, 2023). Consistent with these studies, this study found that DOBS, TAC and CDAI were negatively associated with the mean AL/PPD and the percentage of sites with an F I G U R E 4 Potential pathomechanism of overall dietary antioxidant intake, methylmalonic acid (MMA) and periodontitis by Figdraw.…”

A Case Control Study Evaluating the Relationship between Vitamin K2 Serum Level and Periodontitis

“…There are also many studies concluding the relationship between periodontitis and serum levels of vitamins such as vitamin D [41] or vitamin C [42]. Parallelly investigators try to assess the influence of vitamins and other supplements intake on the outcomes of the periodontitis treatment and/or progression [43][44][45]. Chuai et al verified the association between vitamin K intake and the progression of periodontal attachment loss in American adults [46], which corresponds to the experimental results by Aral [33].…”