Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint®) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial

Heimer, Maria; Valdeon, Anita; Schwartz, Howard; Sheldon, Eric

doi:10.1186/1475-2891-7-3

Cited by 56 publications

(44 citation statements)

References 25 publications

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“…Additionally, more generic questionnaires such as the Short Form-36, Health Assessment Questionnaire and EuroQol have been used to measure functioning and quality of life more generally in people with osteoarthritis [21,22,[30][31][32].…”

Section: Self-report Measures Of Functionmentioning

confidence: 99%

Measurement of change in function and disability in osteoarthritis: current approaches and future challenges

Jordan

Wilkie

Müller

et al. 2009

Current Opinion in Rheumatology

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Measuring functional change is rightly recognized as critically important in osteoarthritis research. Key challenges that remain include capturing wider elements of disability such as ability to participate in everyday life, and in better capturing the longer, episodic nature of disability in osteoarthritis. Experience from fields outside of osteoarthritis may help advance the measurement of function in longitudinal studies of osteoarthritis and its sensible interpretation.

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Section: Self-report Measures Of Functionmentioning

confidence: 99%

Measurement of change in function and disability in osteoarthritis: current approaches and future challenges

Jordan

Wilkie

Müller

et al. 2009

Current Opinion in Rheumatology

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“…In this study, the improvement was more obvious with patients who performed therapeutic exercises in combination with HA therapy. Meanwhile, when 80 mg of HA was ingested daily for 8 weeks, physical function and total symptoms subscales of the WOMAC scores improved more apparently in the HA group compared with the control group, as did the role-physical and bodily pain subscales of the Short Form-36 Version 2 (SF-36v2) [15]. …”

Section: Introductionmentioning

confidence: 99%

Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo-Controlled Study over a 12-Month Period

Tashiro

Seino²,

Sato³

et al. 2012

The Scientific World Journal

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This study was conducted to investigate the efficacy of oral hyaluronic acid (HA) administration for osteoarthritis (OA) in knee joints. Sixty osteoarthritic subjects (Kellgren-Lawrence grade 2 or 3) were randomly assigned to the HA or placebo group. The subjects in the HA group were given 200 mg of HA once a day everyday for 12 months, while the subjects in the placebo group were given placebo. The subjects in both groups were requested to conduct quadriceps strengthening exercise everyday as part of the treatment. The subjects' symptoms were evaluated by the Japanese Knee Osteoarthritis Measure (JKOM) score. The symptoms of the subjects as determined by the JKOM score improved with time in both the HA and placebo groups. This improvement tended to be more obvious with the HA group, and this trend was more obvious with the subjects aged 70 years or less. For these relatively younger subjects, the JKOM score was significantly better than the one for the placebo group at the 2nd and 4th months after the initiation of administration. Oral administration of HA may improve the symptoms of knee OA in patients aged 70 years or younger when combined with the quadriceps strengthening exercise.

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“…Results from these studies have been mixed [6,8,12,13,15,23,28] and the most recent meta-analysis of glucosamine and chondroitin was non-supportive [29]. …”

Section: Discussionmentioning

confidence: 99%

A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial

Nieman

Shanely

Luo

et al. 2013

Nutr J

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BackgroundThe purpose of this study was to assess the effect of 8-weeks ingestion of a commercialized joint pain dietary supplement (InstaflexTM Joint Support, Direct Digital, Charlotte, NC) compared to placebo on joint pain, stiffness, and function in adults with self-reported joint pain. InstaflexTM is a joint pain supplement containing glucosamine sulfate, methylsufonlylmethane (MSM), white willow bark extract (15% salicin), ginger root concentrate, boswella serrata extract (65% boswellic acid), turmeric root extract, cayenne, and hyaluronic acid.MethodsSubjects included 100 men and women, ages 50-75 years, with a history (>3 months) of joint pain, and were randomized to Instaflex™ or placebo (3 colored gel capsules per day for 8 weeks, double-blind administration). Subjects agreed to avoid the use of non-steroidal anti-inflammatory drugs (NSAID) and all other medications and supplements targeted for joint pain. Primary outcome measures were obtained pre- and post-study and included joint pain severity, stiffness, and function (Western Ontario and McMaster Universities [WOMAC]), and secondary outcome measures included health-related quality of life (Short Form 36 or SF-36), systemic inflammation (serum C-reactive protein and 9 plasma cytokines), and physical function (6-minute walk test). Joint pain symptom severity was assessed bi-weekly using a 12-point Likert visual scale (12-VS).ResultsJoint pain severity was significantly reduced in Instaflex™ compared to placebo (8-week WOMAC, ↓37% versus ↓16%, respectively, interaction effect P = 0.025), with group differences using the 12-VS emerging by week 4 of the study (interaction effect, P = 0.0125). Improvements in ability to perform daily activities and stiffness scores in Instaflex™ compared to placebo were most evident for the 74% of subjects reporting knee pain (8-week WOMAC function score, ↓39% versus ↓14%, respectively, interaction effect P = 0.027; stiffness score, ↓30% versus ↓12%, respectively, interaction effect P = 0.081). Patterns of change in SF-36, systemic inflammation biomarkers, and the 6-minute walk test did not differ significantly between groups during the 8-week studyConclusionsResults from this randomized, double blind, placebo-controlled community trial support the use of the Instaflex™ dietary supplement in alleviating joint pain severity in middle-aged and older adults, with mitigation of difficulty performing daily activities most apparent in subjects with knee pain.Trial registrationClinicalTrials.gov Identifier: NCT01956500

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Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint®) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial

Cited by 56 publications

References 25 publications

Measurement of change in function and disability in osteoarthritis: current approaches and future challenges

Measurement of change in function and disability in osteoarthritis: current approaches and future challenges

Oral Administration of Polymer Hyaluronic Acid Alleviates Symptoms of Knee Osteoarthritis: A Double-Blind, Placebo-Controlled Study over a 12-Month Period

A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial

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