Effect of a new synbiotic supplement on symptoms, stool consistency, intestinal transit time and gut microbiota in patients with severe functional constipation: a pilot randomized double-blind, controlled trial

Bazzocchi, Gabriele; Giovannini, Tiziana; Giussani, C.; Brigidi, Patrizia; Turroni, Silvia

doi:10.1007/s10151-014-1201-5

Cited by 28 publications

(30 citation statements)

References 48 publications

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“…The benefits of pro, pre or synbiotic supplementation are known as beneficial to gut functionality. Studies similar to ours, in any way, have shown that probiotic intake (which are related to synbiotic) is capable of improving constipation in general population; the benefits pointed by the studies included increasing in the colonic transit (30) ; improvement in evacuation frequency (31) ; improvement in stool consistency (32) , among others. The benefits of these substances seem to be more pronounced when planned to specific groups, such as the ones diagnosed as functional constipation (33) .…”

Section: Discussionsupporting

confidence: 65%

Effects of Synbiotic Supplementation on Gut Functioning and Systemic Inflammation of Community-Dwelling Elders - Secondary Analyses From a Randomized Clinical Trial

Neto

Chella

Rudnik

et al. 2020

Arq. Gastroenterol.

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BACKGROUND: Aging is a complex process marked by alterations on gut functioning and physiology, accompanied by an increase on the inflammatory status, leading to a scenario called “inflammaging”. OBJECTIVE: To evaluate the effects of a synbiotic substance on systemic inflammation, gut functioning of community-dwelling elders. METHODS: This is a secondary analysis from a randomized clinical trial, lasting 24 weeks, including 49 elders, distributed into two groups: SYN (n=25), which received a synbiotic substance (Frutooligossacaride 6g, Lactobacillus paracasei LPC-31 109 to 108 UFC, Lactobacillus rhamnosus HN001 109 to 108 UFC, Lactobacillus acidophilus NCFM 109 to 108 UFC e Bifidobacterium lactis HN019 109 to 108 UFC), or PLA (n=24), receiving placebo. The evaluations consisted of serum IL-10 e TNF-α (after overnight fasting), evaluation of chronic constipation (by Rome III Criteria) and faeces types (by Bristol Stool Form Scale). Data were compared before and after the supplementation time, and between groups. RESULTS: No significant differences were found between baseline and final values of serum inflammatory markers. Some subtle beneficial changes were observed in SYN, concerning both gut functioning and faeces types. CONCLUSION: From our data, synbiotic supplementation showed a subtle benefit in gut functioning in apparently healthy community-dwelling elders. Our findings can suggest that the benefits in healthy individuals were less expressive than the ones presented in studies with individuals previously diagnosed as dysbiosis. Future studies, comparing elders with and without gut dysbiosis can confirm our findings.

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Section: Discussionsupporting

confidence: 65%

Effects of Synbiotic Supplementation on Gut Functioning and Systemic Inflammation of Community-Dwelling Elders - Secondary Analyses From a Randomized Clinical Trial

Neto

Chella

Rudnik

et al. 2020

Arq. Gastroenterol.

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“…Of the remaining 27 which were analyzed in detail, nine studies evaluated prebiotics or synbiotics for other diseases, two studies did not have a control group, two studies had no extractable data, in one study, synbiotics were given with laxative. As a result, we included five RCTs [17,[22][23][24][25] involving 199 patients who used prebiotics and eight RCTs [16,[26][27][28][29][30][31][32] involving 825 patients who used synbiotics. A flow diagram of studies identified in the search is shown in Figure 1.…”

Section: Eligible Rctsmentioning

confidence: 99%

“…Of the 13 included trials, nine used a parallel-group design [16,17,23,24,[26][27][28][29][30] and four used a crossover design [22,25,31,32] . These studies were performed in Argentina [31] , Brazil [17,27,29] , Finland [22,25] , Italy [16] , Iran [26] , Japan [30,32] , Malaysia [28] , Spain [23] , and the United Kingdom [24] . Sample sizes analyzed in the studies ranged from 14 to 266 participants, and follow-up ranged from 7 to 56 days.…”

Section: Eligible Rctsmentioning

confidence: 99%

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Effects of Prebiotics and Synbiotics on Functional Constipation

Zheng

Tan

et al. 2017

The American Journal of the Medical Sciences

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“…Undernutrition, a condition widely present among hospitalised patients, further impairs the immunologic/inflammatory response, thus increasing the risk of infections (2) . Symbiotics, 'a mixture of probiotics and prebiotics that beneficially affects the host by improving the survival and implantation of live microbial dietary supplements in the gastrointestinal tract, by selectively stimulating the growth and/ or by activating the metabolism of one or a limited number of health-promoting bacteria, and thus improving host welfare' (3) , have been reported to affect intestinal function and permeability (4) . The mechanisms of action can be related to the modulation of the intestinal barrier function, the production of cytokines and immunoglobulins with anti-inflammatory properties, and the capacity to compete against pathogenic bacteria and inhibit their adherence, thus reducing gut permeability and decreasing BT.…”

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confidence: 99%

Postoperative symbiotic in patients with head and neck cancer: a double-blind randomised trial

2017

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Studies on the 'gut origin of sepsis' have suggested that stressful insults, such as surgery, can affect intestinal permeability, leading to bacterial translocation. Symbiotics have been reported to be able to improve gut permeability and modulate the immunologic system, thereby decreasing postoperative complications. Therefore we aimed to evaluate the postoperative use of symbiotics in head and neck cancer surgical patients for intestinal function and permeability, as well as the postoperative outcomes. Patients were double-blind randomised into the symbiotic (n 18) or the control group (n 18). Samples were administered twice a day by nasoenteric tube, starting on the 1st postoperative day until the 5th to 7th day, and comprised 109 colony-forming units/ml each of Lactobacillus paracasei, L. rhamnosus, L. acidophilus, and Bifidobacterium lactis plus 6 g of fructo-oligosaccharides, or a placebo (6 g of maltodextrin). Intestinal function (day of first evacuation, total stool episodes, stool consistency, gastrointestinal tract symptoms and gut permeability by diamine oxidase (DAO) enzyme) and postoperative complications (infectious and non-infectious) were assessed. Results of comparison of the pre- and postoperative periods showed that the groups were similar for all outcome variables. In all, twelve patients had complications in the symbiotic group v. nine in the control group (P>0·05), and the preoperative-postoperative DAO activity ranged from 28·5 (sd 15·4) to 32·7 (sd 11·0) ng/ml in the symbiotic group and 35·2 (sd 17·7) to 34·1 (sd 12·0) ng/ml in the control group (P>0·05). In conclusion, postoperative symbiotics did not impact on intestinal function and postoperative outcomes of head and neck surgical patients.

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Effect of a new synbiotic supplement on symptoms, stool consistency, intestinal transit time and gut microbiota in patients with severe functional constipation: a pilot randomized double-blind, controlled trial

Abstract: An 8-week treatment with Psyllogel Megafermenti(®) improved the main clinical parameters of functional constipation in patients extremely homogeneous for disorder severity and underlying pathophysiology ( Eudract.ema.europa.eu , No. 2008-000913-30).

Cited by 28 publications

References 48 publications

Effects of Synbiotic Supplementation on Gut Functioning and Systemic Inflammation of Community-Dwelling Elders - Secondary Analyses From a Randomized Clinical Trial

Effects of Synbiotic Supplementation on Gut Functioning and Systemic Inflammation of Community-Dwelling Elders - Secondary Analyses From a Randomized Clinical Trial

Effects of Prebiotics and Synbiotics on Functional Constipation

Postoperative symbiotic in patients with head and neck cancer: a double-blind randomised trial

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