Effect of a newly developed ready-to-use supplementary food on growth indicators in children with mild to moderate malnutrition

Azimi, Faramarz; Esmaillzadeh, Ahmad; Alipoor, Elham; Moslemi, Masoumeh; Yaseri, Mehdi; Hosseinzadeh‐Attar, Mohammad Javad

doi:10.1016/j.puhe.2020.06.025

Cited by 19 publications

(22 citation statements)

References 24 publications

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“…A significantly lower prevalence of both diarrhoea (n=6 (12%) vs n=14 (28·6%), p=0·01), and fever (8 (16%) vs 18 (36·7%), p=0·05) was observed in children treated with an LNS compared to usual diet 13 .…”

Section: Study Resultsmentioning

confidence: 89%

“…Twelve studies were conducted in African countries, the other in Iran 13 . Two were in urban areas; ten in rural settings; one was set in both an urban and rural area.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies compared treatment of MAM with a food supplement versus a non-food supplement 13,18 . One compared child-centered counselling (CCC) with a blended food (CSB++) and LNS (RUSF) in Burkina Faso; the other compared an LNS (RUSF) with usual diet and nutrition education in Iran.…”

Section: Study Resultsmentioning

confidence: 99%

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The management of Moderate Acute Malnutrition (MAM) in children aged 6-59 months: A systematic review and meta-analysis

Gluning

Kerac

Bailey

et al. 2021

Preprint

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BackgroundMalnutrition is a leading cause of morbidity and mortality in children aged under five years, especially in low- and middle-income countries (LMICs). Although severe acute malnutrition (SAM) is considered the most serious form of malnutrition, moderate acute malnutrition (MAM) affects greater numbers globally and, unlike SAM, guidelines lack a robust evidence-base. This systematic review and meta-analysis assessed the evidence for lipid-based nutrient supplements (LNS), fortified-blended-flours (FBF) and nutrition counselling, in the treatment of MAM.MethodsFive databases were systematically searched for studies conducted in LMICs that compared the effectiveness of food-based products versus any comparator group in promoting recovery from MAM in children aged 6-59 months. Where appropriate, pooled estimates of effect were estimated using random-effects meta-analyses.ResultsA total of thirteen trials were identified for inclusion. All used active controls rather than ‘standard care’, which is often minimal in most settings. There was evidence of increased probability of recovery (as assessed by gaining normal weight-for-height and/or MUAC) among children treated with LNS compared to children treated with FBF (RR 1·05, 95%CI 1·01-1·09, p=0·009). Treatment with an LNS was also associated with a lower risk of persistent MAM at the end of treatment compared with a FBF (RR 0·82, 95%CI 0·71-0·95, p=0·007).ConclusionBased on a relatively small number of studies mainly from Africa, LNS are superior to FBF in improving anthropometric recovery from MAM. The true benefit of MAM treatment may be underestimated due to all studies using active controls rather than usual care which is minimal.More high-quality evidence is needed to evaluate nutrition education/counselling alone as a MAM intervention. Studies should also assess a wider range of outcomes including body composition, morbidity and development – not weight-gain alone.

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Section: Study Resultsmentioning

confidence: 89%

“…Twelve studies were conducted in African countries, the other in Iran 13 . Two were in urban areas; ten in rural settings; one was set in both an urban and rural area.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The management of Moderate Acute Malnutrition (MAM) in children aged 6-59 months: A systematic review and meta-analysis

Gluning

Kerac

Bailey

et al. 2021

Preprint

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“…This systematic review and meta-analysis aimed to investigate the effectiveness of RUSF compared to any other dietary supplementation intervention or no intervention on functioning at different levels of the ICF among children with MAM aged between 2 and 12 years old. The review summarises the findings from a total of seven studies, which include 6476 MAM children, (36,(38)(39)(40)(41)(42)(43)(44) aged between 6 months and 5 years. Despite the lack of strong evidence in the included literature, RUSF supplementation showed greater advantages in the…”

Section: Discussionmentioning

confidence: 99%

“…None of the included studies looked into the children's developmental features at a motor, cognitive, or social level, even though these issues have been established in these children in previous research. (36,(38)(39)(40)(41)(42)(43)(44) The link between the changes that occur in the nutritional status of MAM children and the type of supplementation or the changes at other levels of functioning and how they are intertwined needs to be disentangled in future research. Furthermore, supplements are given to strengthen the MAM children and empower them to participate in activities of daily life.…”

Section: Clinical Implications and Recommendations For Future Researchmentioning

confidence: 99%

Current evidence on the effectiveness of Ready-to-Use Supplementary Foods in children with moderate acute malnutrition: a systematic review and meta-analysis

Teshome,

Lema,

Abessa

et al. 2023

J Nutr Sci

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Moderate acute malnutrition (MAM) is defined by a weight-for-height Z-score (WHZ) between −3 and −2 of the WHO reference or by a mid-upper arm circumference (MUAC) of ≥11⋅5 and <12⋅5 cm. This study aimed to synthesise the evidence for the effectiveness of Ready-to-Use Supplementary Food (RUSF) compared to other dietary interventions or no intervention on functioning at different levels of the International Classification of Functioning, Disability, and Health (ICF) among children with MAM between 2 and12 years old. Three databases (PubMed, Scopus, and Web of Science) were systematically searched (last update: 20 November 2022). Pooled estimates of effect were calculated using random-effects meta-analyses. The level of evidence was estimated with the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) method. Seven studies were included. RUSF had a significant small-sized better effect (pooled mean: 0⋅38; 95 % CI = [0⋅10, 0⋅67], P = 0⋅01, I² = 97 %) on different anthropometric measurements compared to other dietary interventions among MAM children (n 6476). Comparing RUSF with corn–soy blend Plus Plus (CSB++) showed that RUSF had a small-sized but significantly better effect on the children's anthropometric measures compared to children who received CSB++ (pooled mean: 0⋅16; 95 % CI = [0⋅05, 0⋅27], P = 0⋅01; I2 = 35 %). MAM children treated with RUSF had a better recovery rate compared to those treated with CSB++ (pooled risk difference: 0⋅11; 95 % CI = [0⋅06, 0⋅11], P < 0⋅001; I2 = 0 %). The RUSF intervention seems promising in improving MAM children's nutritional outcomes and recovery rate compared to other dietary interventions.

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A fermented milk drink with Umbu (Spondias tuberosa) pulp and whey is effective for weight gain and re-nutrition in malnourished: An in vivo study in mice and children

Mendes,

Souza,

Lopes

et al. 2024

Food Research International

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Effect of a newly developed ready-to-use supplementary food on growth indicators in children with mild to moderate malnutrition

Cited by 19 publications

References 24 publications

The management of Moderate Acute Malnutrition (MAM) in children aged 6-59 months: A systematic review and meta-analysis

The management of Moderate Acute Malnutrition (MAM) in children aged 6-59 months: A systematic review and meta-analysis

Current evidence on the effectiveness of Ready-to-Use Supplementary Foods in children with moderate acute malnutrition: a systematic review and meta-analysis

A fermented milk drink with Umbu (Spondias tuberosa) pulp and whey is effective for weight gain and re-nutrition in malnourished: An in vivo study in mice and children

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