Effect of a novel bioactive glass-ceramic on dentinal tubule occlusion: anin vitrostudy

Abstract

Background: This in vitro study aimed to assess the ability and efficacy of HX-BGC, a novel bioactive glass-ceramic (SiO 2 -P 2 O 5 -CaO-Na 2 O-SrO), to reduce dentine tubule permeability. Methods: Dentine discs from human third molars were etched and randomly allocated into five groups: Group 1 -distilled water; Group 2 -Sensodyne Repair toothpaste (containing NovaMin®); Group 3 -HX-BGC toothpaste (containing 7.5% HX-BGC); Group 4 -control toothpaste (without HX-BGC); and Group 5 -HX-BGC powder. Specimens were treated daily by brushing with an electric toothbrush for 20 seconds. Between daily treatments (7 days total), specimens were immersed in artificial saliva for 24 hours. Dentine permeability was measured at baseline, after the first treatment, after the first 24-hour immersion in artificial saliva and at the end of day 7. Dentine morphology and surface deposits were observed by scanning electron microscopy after one day and 7 days of treatment, respectively. Results: Sensodyne Repair and bioactive glass-ceramic toothpaste significantly and immediately lowered dentine permeability. The HX-BGC powder group showed the highest reduction in dentine permeability after 7 days of treatment. Conclusions: The novel bioactive glass-ceramic material HX-BGC is effective in reducing dentine permeability by occluding open dentine tubules, indicating that HX-BGC may be a potential treatment for dentine hypersensitivity.

Enhanced bioactive properties of BiodentineTM modified with bioactive glass nanoparticles

“…When BG has been added to other carriers, such as toothpastes, it has been demonstrated that the dentin tubule occlusion layer formed is resistant to acid challenge 5 , and reduces significantly dentine permeability under simulated oral environment 30 . In addition, it has been suggested that the apatite rods formed into dentine tubules after brushing with nBGs slurries would have excellent retention 4 .…”

Bioactive and inert dental glass‐ceramics

“…The highest reduction in dentine permeability was observed after 7 days of treatment . Figure shows the formation of apatite‐like crystals inside dentine tubules and on its surface after brushing of the dentine with toothpaste containing bioactive glass‐ceramic . One interesting advantage presented by glass‐ceramics in this application is that because these materials are fully crystalline, they do not present sharp cutting surfaces.…”

“…Bioactive glass‐ceramic toothpaste significantly and immediately lowered dentine permeability. The highest reduction in dentine permeability was observed after 7 days of treatment . Figure shows the formation of apatite‐like crystals inside dentine tubules and on its surface after brushing of the dentine with toothpaste containing bioactive glass‐ceramic .…”

“…One interesting advantage presented by glass‐ceramics in this application is that because these materials are fully crystalline, they do not present sharp cutting surfaces. In contrast, glasses possess conchoidal fracture surfaces that can lead to gum irritation during brushing . Therefore, bioactive glass‐ceramics deserve much more attention for this application.…”

“… SEM images show apatite‐like deposits inside the dentine tubules (a) and on the dentine surface (b) after 7 days of treatment with toothpaste filled with a bioactive glass‐ceramic …”