2010
DOI: 10.1111/j.1365-3164.2009.00782.x
|View full text |Cite
|
Sign up to set email alerts
|

Effect of a novel topical diester glucocorticoid spray on immediate- and late-phase cutaneous allergic reactions in Maltese-beagle atopic dogs: a placebo-controlled study

Abstract: The inhibitory effect of 0.0584% hydrocortisone aceponate spray on immediate- and late-phase skin reactions and the duration of inhibition after medication withdrawal were studied in 10 Maltese-beagle atopic dogs. All subjects were sprayed on axillary and inguinal regions and on one randomly chosen side of the thorax once daily for 14 (phase 1) or 7 days (phase 2). Intradermal injections (IDT) of histamine and anticanine IgE antiserum were performed bilaterally on the thorax before, 7 and 14 days after treatme… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
40
0
1

Year Published

2012
2012
2017
2017

Publication Types

Select...
5
3

Relationship

1
7

Authors

Journals

citations
Cited by 35 publications
(42 citation statements)
references
References 27 publications
1
40
0
1
Order By: Relevance
“…Indeed, similar findings emerged from a study on a model of chronic inflammation, where the local administration of adelmidrol both down-modulated MC degranulation and prevented numerical increase of MC numbers [20]. Interestingly, topical corticosteroids decrease MC numbers in humans [56], without any apparent effect on dogs [44]. …”
Section: Discussionmentioning
confidence: 59%
See 1 more Smart Citation
“…Indeed, similar findings emerged from a study on a model of chronic inflammation, where the local administration of adelmidrol both down-modulated MC degranulation and prevented numerical increase of MC numbers [20]. Interestingly, topical corticosteroids decrease MC numbers in humans [56], without any apparent effect on dogs [44]. …”
Section: Discussionmentioning
confidence: 59%
“…The key findings are summarized in Table 2. The effect of corticosteroids (both oral or topical) on intradermally-induced skin wheal ranges from lack of effect [38,39] up to 45% inhibition [40-43], with the only exception of one single study (72% inhibition rate) [44]. Interestingly, similar results are observed in allergic human patients (i.e., 30-40% inhibition) [45], and better outcomes are known to occur with longer treatment [46].…”
Section: Discussionmentioning
confidence: 99%
“…injections were significantly reduced on both treated and untreated sides of the thorax after 7 and 14 days. Normal to near normal immediate reactivity to histamine returned at untreated sites within 2 weeks of discontinuation of treatment …”
Section: Resultsmentioning
confidence: 99%
“…In summary, the variability of the study designs and products used renders the determination of universal OWT and MWT difficult. Nevertheless, based on the evidence available from the testing of a potent topical glucocorticoid (Cortavance; Virbac, Carros, France), an OWT of 14 days is proposed (Table ). For lower‐potency topical glucocorticoid formulations, an MWT of 0 days is likely to be possible …”
Section: Resultsmentioning
confidence: 99%
“…Dogs were off all oral antihistamines, cyclosporine for a minimum of 1 month, essential fatty acid supplements, and long-acting injectable glucocorticoids for a minimum of 2 months while oral [26] and topical glucocorticoids for a variable time (5–14 days) [27]. The withdrawal time took into consideration also the type of glucocorticoids prescribed and the duration of treatment, as it would be done in clinical practice before intradermal skin testing.…”
Section: Methodsmentioning
confidence: 99%