Effect of a nutritional supplementation on growth and body composition in short and lean preadolescent boys: A randomised, double‐blind, placebo‐controlled study

Shvalb, Naama Fisch; Lazar, Liora; Demol, Sharon; Mouler, Marie; Rachmiel, Marianna; Hershkovitz, Eli; Shamir, Raanan; Phillip, Moshe; Yackobovitch‐Gavan, Michal

doi:10.1111/apa.16054

Cited by 3 publications

(12 citation statements)

References 17 publications

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“…In the extension phase and the 12-month analysis, participants who were good formula consumers managed to maintain their height-SDS score, while the poor formula consumers showed a significant decline in their height-SDS. This result is in line with the positive effect on height-SDS observed in the first phase of the study among the older participants [6].…”

Section: Discussionsupporting

confidence: 88%

The Effect of a Nutritional Supplement on Growth and Body Composition in Short and Lean Preadolescent Boys following One Year of Intervention

Yackobovitch‐Gavan¹,

Lazar²,

Demol³

et al. 2022

Horm Res Paediatr

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Introduction: Adequate nutrition plays an important role in linear growth throughout childhood, including puberty. However, not all children are willing or able to consume an adequate balanced diet daily. We aimed to evaluate the 1-year effectiveness and safety of nutritional supplementation on linear growth, weight gain, and changes in body composition in short and lean peripubertal boys. Methods: A one-year, 2-phase multicenter interventional study comprising 1-6 months of a double-blinded intervention with nutritional formula or placebo, followed by 6-12 months of an open-label extension with the nutritional formula for all participants. Results: The outcomes of the double-blinded intervention were reported previously. A total of 79/98 (81%) boys, aged ≥10 years, Tanner stages 1-3, completed the open-labeled extension-phase. For this phase, a significant dose-response correlation (P<0.05) was found of the consumption of the formula with Δ height-SDS, Δ weight-SDS, and Δ muscle-mass (crude correlations and after adjustment for baseline age and end-of-study Tanner stage). In the extension phase and in the 12-month analysis, participants who were good formula consumers (intake ≥50% of recommended dose) maintained their height-SDS, while poor consumers had a significant decline in their height-SDS (P=0.028 and P=0.009, between group difference in the extension phase and 12-months analysis, respectively). Between-group differences were not observed in Tanner stage at any point of the study. No serious adverse events were reported. Conclusions: An intervention in healthy peripubertal boys suggests that one year consumption of a multi-nutrient, protein-rich nutritional supplement is efficacious and safe. The induced changes in growth and body composition, although modest, may be clinically significant. The effect of the formula on growth parameters was not mediated by enhancement of the pubertal tempo.

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Section: Discussionsupporting

confidence: 88%

The Effect of a Nutritional Supplement on Growth and Body Composition in Short and Lean Preadolescent Boys following One Year of Intervention

Yackobovitch‐Gavan¹,

Lazar²,

Demol³

et al. 2022

Horm Res Paediatr

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“…Ghosh et al and Alarcon et al suggest that the incidence of upper respiratory tract infections developed over the study period was significantly lower in the ONS + DC group compared to the control group [ 96 , 97 ]. Likewise, the effects of the high-protein ONS diet have also been assessed in healthy short and lean children [ 100 , 101 , 102 ]. Lebenthal et al [ 100 ] evaluated the intake of a high-protein ONS (24.5 g protein/serving) diet for 6 months in 171 short and lean children aged 3–9 years.…”

Section: Optimal Protein Intake In Picky Eatersmentioning

confidence: 99%

“…In the follow-up study, Yackbovitch-Gavan et al [ 101 ] reported similar results, suggesting that a one-year intervention with a high-protein ONS diet was effective in promoting the linear growth of these children, with no change in BMI. In contrast, in a similar approach in short and lean prepubertal boys (10–14.5 y), results reported a change in body composition [ 102 ]. The intervention included two phases: a double-blinded intervention with a high-protein ONS (36 g protein/serving) diet or placebo for 6 months, and subsequently, an open-label, extended 6-month diet containing ONS, for all the participants.…”

Section: Optimal Protein Intake In Picky Eatersmentioning

confidence: 99%

“…The intervention included two phases: a double-blinded intervention with a high-protein ONS (36 g protein/serving) diet or placebo for 6 months, and subsequently, an open-label, extended 6-month diet containing ONS, for all the participants. It was reported that ‘good’ formula consumers showed significantly increased weight-SDS, BMI-SDS, fat-free mass and muscle mass when compared to ‘poor’ consumers and the placebo group [ 102 ]. Nevertheless, it should be mentioned that while the body composition described by the authors could be relevant to with PE children, the presence of picky eating or any other behavior related to the refusal to eat adequately was not assessed [ 100 , 101 , 102 ].…”

Section: Optimal Protein Intake In Picky Eatersmentioning

confidence: 99%

“…It was reported that ‘good’ formula consumers showed significantly increased weight-SDS, BMI-SDS, fat-free mass and muscle mass when compared to ‘poor’ consumers and the placebo group [ 102 ]. Nevertheless, it should be mentioned that while the body composition described by the authors could be relevant to with PE children, the presence of picky eating or any other behavior related to the refusal to eat adequately was not assessed [ 100 , 101 , 102 ].…”

Section: Optimal Protein Intake In Picky Eatersmentioning

confidence: 99%

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Optimal Protein Intake in Healthy Children and Adolescents: Evaluating Current Evidence

et al. 2023

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High protein intake might elicit beneficial or detrimental effects, depending on life stages and populations. While high protein intake in elder individuals can promote beneficial health effects, elevated protein intakes in infancy are discouraged, since they have been associated with obesity risks later in life. However, in children and adolescents (4–18 years), there is a scarcity of data assessing the effects of high protein intake later in life, despite protein intake being usually two- to three-fold higher than the recommendations in developed countries. This narrative review aimed to revise the available evidence on the long-term effects of protein intake in children and adolescents aged 4–18 years. Additionally, it discusses emerging techniques to assess protein metabolism in children, which suggest a need to reevaluate current recommendations. While the optimal range is yet to be firmly established, available evidence suggests a link between high protein intake and increased Body Mass Index (BMI), which might be driven by an increase in Fat-Free Mass Index (FFMI), as opposed to Fat Mass Index (FMI).

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Dietary intake and sleep in late childhood – do shorter children have distinct patterns?

Fisch-Shvalb,

Zur,

Lazar

et al. 2024

Pediatr Res

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Background The exceptional growth rate during adolescence demands increased dietary intake. We aimed to compare diet and lifestyle of pre-adolescents with height and weight below the 10th percentile, with those of pre-adolescents of higher height and weight. Methods This case-control study included healthy pre-pubertal girls (≥9 years) and boys (≥10 years). The case groups included 31 girls and 32 boys with height and weight <10th percentile, and weight percentile ≤height percentile. The control groups comprised 24 girls and 24 boys, with height ≥25th percentile, BMI 5th–85th percentiles. Participants completed 3-day food diaries and lifestyle-related questionnaires. Results Energy intake/estimated-requirement and protein/body-weight were comparable in the case and control groups, both in boys and girls. In boys, fat (P = 0.050) and carbohydrate (P ≤ 0.001) intakes/body-weight were higher in the case group versus controls; and iron (P < 0.001), zinc (P = 0.005), vitamin A (P < 0.001), calcium (P = 0.005), and vitamin C (P = 0.034) consumption were lower. In girls, carbohydrate/body-weight was higher in the case group compared to controls (P = 0.007); micronutrient intake was comparable, and lower than recommended. Compared to controls, short and thin boys reported less sleep during weekdays (P < 0.001). Conclusions Relatively short, thin pre-adolescents may have distinct dietary intake and sleeping patterns compared to taller peers, especially boys. Impact Nutrition is a key environmental determinant of childhood growth. Not much is known about late nutritional impact on growth in children whose anthropometric indices are below the 10th percentile. We compared food diaries and lifestyle questionnaires of pre-pubertal pre-adolescents with height <10th percentiles and weight≤height for age and sex, with those of peers with indices in higher percentiles. We found distinct differences in micronutrient intakes and sleep duration in the shorter boys, but no energy deficit in either sex. We suggest that diet and lifestyle parameters should be evaluated in children with relatively low anthropometric indices, to ensure optimal growth.

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Effect of a nutritional supplementation on growth and body composition in short and lean preadolescent boys: A randomised, double‐blind, placebo‐controlled study

Cited by 3 publications

References 17 publications

The Effect of a Nutritional Supplement on Growth and Body Composition in Short and Lean Preadolescent Boys following One Year of Intervention

The Effect of a Nutritional Supplement on Growth and Body Composition in Short and Lean Preadolescent Boys following One Year of Intervention

Optimal Protein Intake in Healthy Children and Adolescents: Evaluating Current Evidence

Dietary intake and sleep in late childhood – do shorter children have distinct patterns?

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