2005
DOI: 10.1248/bpb.28.1886
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Effect of a Nutritive-Tonic Drink on Scopolamine-Induced Memory Impairment in Mice

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Cited by 12 publications
(9 citation statements)
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“…Therefore, extensive searches are being carried out for novel, naturally occurring active compounds that can be used to treat multiple-factor dementia. Numerous medicinal plant species are now being screened for advanced therapeutic drugs that possess both high efficacy and low side effects [1][2][3][4][5] . One such plant, Polygala tenuifolia Willd, is the species of interest in this study.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, extensive searches are being carried out for novel, naturally occurring active compounds that can be used to treat multiple-factor dementia. Numerous medicinal plant species are now being screened for advanced therapeutic drugs that possess both high efficacy and low side effects [1][2][3][4][5] . One such plant, Polygala tenuifolia Willd, is the species of interest in this study.…”
Section: Introductionmentioning
confidence: 99%
“…(Heidari et al, 2006;Ma et al, 2007;Stone et al, 1990) Increasing locomotor activity induced by morphine in rodents was thought to reflect dopamine release in the striatum (Murphy et al, 2001;Porras et al, 2003). Scopolamine was found to increase dopamine release depended on doses (Ichikawa et al, 2002) , and indirectly improved locomotor activity (Bauer, 1982;Chintoh et al, 2003;Joyce & Koob, 1981;Sakata et al, 2005) .Therefore we assumed that the hyper-locomotor activity, which was found in our experiment, was considered as the result from the cooperation of morphine and scopolamine to up-regulate the dopamine level. Atropine showed no effect on the locomotor activity both when administrating alone and co-administering with morphine.…”
Section: Discussionmentioning
confidence: 70%
“…The doses of scopolamine and atropine were conducted following several former researches in which the drugs effectively cause amnesia in mice (Jafari et al, 2006;Kim et al, 2006;Sakata et al, 2005). 1.4.2 Experiment 2 In experiment 1, all groups showed the impairments of the spatial recognition memory retrieval except the controls.…”
Section: Treatmentmentioning
confidence: 99%
“…These herbs include Lycium barbarum, Ginkgo biloba L., Lycoris radiata, Magnolia officinalis, Poly-gala tenuifolia WILLD, Ginseng Radix and Scrophularis buerheriana. [50][51][52][53][54][55] Other studies reported that the water extract of Polygalae Radix increased ChAT activity and NGF secretion in vitro 56) and its compound, acylated oligosaccharide, has cognition improving effects and cerebral protective effects. 57) An acidic oligosaccharide extracted from the brown algae, Echlonia Kurome OKAM, by enzymatic depolymerization attenuates the memory impairment induced by scopolamine, as evaluated by a shortened escape latency, a shortened swimming distance and an increased retention time in the quadrant where the platform was placed in a Morris water maze task.…”
Section: Discussionmentioning
confidence: 99%