Effect of a proteinase inhibitor on intermittent claudication or on pain at rest in patients with peripheral arterial disease

Digiesi, V.; Bartoli, V.; B, Dorigo

doi:10.1016/0304-3959(75)90076-7

Cited by 10 publications

(2 citation statements)

References 7 publications

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“…Other authors suggested the release of kinins (e.g. bradykinin) as a possible cause for ischaemic pain (Sicuteri, Franchi & Fanciullacci, 1964;Digiesi, Bartoli & Dorigo, 1975). Our data have shown that this substance sensitizes high-threshold muscle receptors so that they respond to innocuous mechanical stimuli (Mense & Meyer, 1981).…”

Section: Discussionsupporting

confidence: 54%

Responses in muscle afferent fibres of slow conduction velocity to contractions and ischaemia in the cat.

Mense¹,

Stahnke²

1983

The Journal of Physiology

366

226

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SUMMARY1. The aim ofthe study was to find out to what extent muscle receptors with slowly conducting afferent fibres (group III and IV) are activated by muscular contractions of moderate force, and what kind of muscle afferents could mediate the pain of ischaemic exercise.2. In chloralose-anaesthetized cats, the impulse activity of single afferent units from the triceps surae muscle was recorded from dorsal root filaments during muscular contractions with intact blood supply and after occlusion of the muscle artery.3. Two types of responses were observed to contractions without muscular ischaemia. One was characterized by sudden onset and a graded response amplitude to contractions of increasing force. In most cases stretching the muscle was also an effective stimulus. Units showing this response behaviour were labelled c.s.m (contraction-sensitive with mechanical mechanism of activation). The other response type had a more delayed onset and often outlasted the exercise period; because of the unknown mechanism of activation, units of this kind were labelled c.s.X. The proportion of c.s.m receptors was significantly higher amongst group III than amongst group IV units. 4. During ischaemic contractions of comparable force the c.s.m and c.s.. receptors exhibited an unchanged or a decreased response amplitude. Under these conditions another receptor type (N, for nociceptive) was activated which did not respond to contractions with intact blood supply. Vigorous activations during ischaemic work were only observed in group IV receptors.5. The majority of the 131 group III and IV units tested did not respond to contractions at all. These contraction-insensitive (c.i.) endings probably comprised different receptor populations (nociceptors, thermoreceptors, low-threshold mechanoreceptors).6. It is concluded that the various central nervous effects of muscular exercise without ischaemia which are known to be due to raised activity in thin muscle afferents (e.g. cardiopulmonary adjustments, spinal locomotor reflexes) are probably produced by the c.s.m and c.s.x types. The pain ofischaemic contractions is most likely mediated by the N receptors most of which possess non-myelinated afferent fibres.

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Section: Discussionsupporting

confidence: 54%

Responses in muscle afferent fibres of slow conduction velocity to contractions and ischaemia in the cat.

Mense¹,

Stahnke²

1983

The Journal of Physiology

366

226

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“…It is likely that the powerful analgesic effect of aprotinin is because of its indirect anti-kinin property, although a certain degree of pro-endorphin activity cannot be excluded. The same process may play a part in analgesia displayed by aprotinin in intermittent claudication (17).…”

mentioning

confidence: 89%

Enkephalinase Inhibition Relieves Pain Syndromes of Central Dysnociception (Migraine and Related Headache)

Sicuteri

1981

Cephalalgia

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Normotensive and hypertensive headache sufferers were treated with D-phenylalanine, aprotinin or captopril--all inhibitors of endogenous opioid degradation. Inconsistent results were obtained using D-phenylalanine and aprotinin (acute administration at the start of a migraine attack). Satisfactory results were obtained by prophylactic treatment with captopril (an inhibitor of the angiotensin converting enzyme and of the dipeptidyl carboxypeptidase--an enkephalin inactivating enzyme) compared with conventional drugs such as methysergide, lisuride, pizotifen, clonidine and beta-blocking agents. Excellent results were obtained with captopril on patients suffering from headache and arterial hypertension who had experienced no relief from beta-blocking agents and clonidine. Captopril could thus be a drug of choice in the therapy of headache associated with essential hypertension.

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Muscle Pain: Understanding the Mechanisms

Mense

Gerwin²

2010

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Effect of a proteinase inhibitor on intermittent claudication or on pain at rest in patients with peripheral arterial disease

Cited by 10 publications

References 7 publications

Responses in muscle afferent fibres of slow conduction velocity to contractions and ischaemia in the cat.

Responses in muscle afferent fibres of slow conduction velocity to contractions and ischaemia in the cat.

Enkephalinase Inhibition Relieves Pain Syndromes of Central Dysnociception (Migraine and Related Headache)

Muscle Pain: Understanding the Mechanisms

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