Effect of a Psidii guajavae folium extract in the treatment of primary dysmenorrhea: A randomized clinical trial

Doubova, Svetlana V; Morales, Hortensia Reyes; Hernández, Sergio Flores; Martínez-García, María del Carmen; Ortiz, Marcela González de Cossío; Soto, Marco A. Chávez; Arce, Erika Rivera; Lozoya, Xavier

doi:10.1016/j.jep.2006.09.033

Cited by 40 publications

(21 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The flavonoids and terpenoids present in Psidium guajava leaf extract have been reported by some investigators to have antispasmodic effects on smooth muscle preparations, and to inhibit inflammation through prostaglandin-synthesis enzymatic system (Doubova et al, 2007). In a study by Revuelta et al (1997), quercetin and kaemferol relaxed rat isolated uteri precontracted with potassium chloride.…”

Section: Discussionmentioning

confidence: 99%

“…Based on our laboratory, experimental findings and the clinical observations of Doubova et al, (2007), leaf extract of Psidium guajava could be recommended as a natural therapeutic alternative to non-steroidal anti-inflammatory drugs (NSAIDs) in the management, control and/or treatment of primary dysmenorrhoea.…”

Section: +mentioning

confidence: 99%

“…Globally, primary dysmenorrhoea is one of the most common gynaecological disorders in young women (Doubova et al, 2007). Women with primary dysmenorrhoea have been found to produce higher levels of prostaglandins (PGF2α) in their endometria, which in turn, increase uterine tones and cause exaggerated uterine muscle contractility (Speroff et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…(family: Myrtaceae), is usually employed traditionally for the management, control and/or treatment of primary dysmenorrhoea in many rural African communities. At present, the Western, conventional treatment of primary dysmenorrhoea depends largely on the administration of non-steroidal anti-inflammatory drugs (NSAIDs) during the painful stages of the menstrual cycle (Doubova et al, 2007). The use of infusions, decoctions and extracts of Psidium guajava leaves for the relief of some menstrual disorders associated with abdominal cramps and discomfort has been documented since ancient times (Conway, 2001).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Spasmolytic effect of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract on rat isolated uterine horns

Chiwororo

Ojewole

2009

J. Smooth Muscle Res.

View full text Add to dashboard Cite

Globally, primary dysmenorrhoea is one of the most frequent gynaecological disorders in young women. It is associated with increased uterine tone, and exaggerated contractility of uterine smooth muscles. In many rural African communities, a number of medicinal plants, including Psidium guajava Linn. (family: Myrtaceae), are used traditionally for the management, control and/or treatment of primary dysmenorrhoea. The present study was, therefore, undertaken to examine the spasmolytic effect of Psidium guajava leaf aqueous extract (PGE) on isolated, spontaneously-contracting and oestrogen-dominated, quiescent uterine horns of healthy, young adult, female Wistar rats. Graded, escalated concentrations of PGE (0.5-4.0 mg/ml) produced concentration-dependent and significant inhibitions of the amplitude of spontaneous phasic contractions of the isolated rat uterine horn preparations. In a concentration-related manner, PGE also significantly inhibited or abolished contractions produced by acetylcholine (ACh, 0.5-8.0 µg/ml), oxytocin (0.5-4.0 µU), bradykinin (2.5-10 ng/ml), carbachol (CCh, 0.5-8.0 µg/ml) or potassium chloride (K + , 10-80 mM) in quiescent uterine horn preparations isolated from the oestrogendominated rats. The spasmolytic effect of PGE observed in the present study lends pharmacological support to the traditional use of 'guava' leaves in the management, control and/or treatment of primary dysmenorrhoea in some rural African communities.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: +mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spasmolytic effect of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract on rat isolated uterine horns

Chiwororo

Ojewole

2009

J. Smooth Muscle Res.

View full text Add to dashboard Cite

show abstract

“…Primary dysmenorrhea (PDM, menstrual pain without pelvic abnormality) is one of the most common gynaecological disorders in young women (Doubova et al, 2007). Hyperactivity of the myometrium with accompanying uterine ischemia is considered critical in the causation of pain.…”

Section: Introductionmentioning

confidence: 99%

Plasma metabolic profiling of normal and dysmenorrhea syndrome rats and the effects of Xiang–Fu–Si–Wu Decoction intervention

Liu

Duan

Guo

et al. 2013

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Primary dysmenorrhea (PDM), a common, clinically heterogeneous endocrine disorder affecting young women, is associated with endocrinopathy and metabolic abnormalities. The Xiang-Fu-Si-Wu Decoction (XFSWD) is a traditional Chinese medicine preparation used to treat PDM. Objective: In the current study, a plasma metabonomics method based on the ultrahigh-performance liquid chromatography-quantitative time-of-flight-mass spectrometry (UHPLC-Q-TOF-MS) system was employed to examine the mechanism of XFSWD action in PDM. Materials and methods: Estradiol benzoate (0.01 g/kg/d) and oxytocin (5 mL/kg) were used to create the dysmenorrhea rat model. Based on the chromatographic data of plasma samples at different time-points following oral administration of XFSWD mixed in water (37.8 g crude herbs/kg) on day 7, partial least square (PLS) and discriminate analysis (DA) were applied to visualize group differentiation and marker selection. Results: Systemic changes occurring in PDM reflect alterations in not only uterus function but also whole-body metabolism. The XFSWD was effective as a therapeutic agent for PDM by reflect metabolic pathway. Prostaglandins and lysophospholipids were identified as two marker types for oxytocin-induced dysmenorrhea syndrome, including LysoPC(18:4), LysoPE(22:2/0:0), LysoPC(17:0), PGJ 2 , 11-deoxy-11-methylene-PGD 2 , 15-deoxy-d-12,14-PGJ 2 , LysoPC(20:3), etc. Specifically, the concentrations of prostaglandins compounds (PGJ 2 , 11-deoxy-11-methylene-PGD 2 , 15-deoxy-d-12,14-PGJ 2 ) were increased while those of lysophospholipid compounds [lysoPC(18:4), LysoPE(22:2/0:0), LysoPC(17:0)] were decreased to a significant extent (p50.05) in dysmenorrheal rats. Upon treatment with the XFSWD at 12 h, the concentrations of lysophospholipids showed no significant differences (P40.05) between the model and normal groups. The lysophospholipid levels were restored. Lysophospholipids were the key factors in phospholipid metabolism. Thus, disruption of phospholipids metabolism appears critical for the development of dysmenorrhea. The XFSWD exerted its effects by interfering with the sphingolipid metabolic pathway. Discussion and conclusions: The metabonomics method presents a promising tool to treat PDM in animal models, and may be applicable for clinical treatment of the human disease in the future.

show abstract

Nonsteroidal anti-inflammatory drugs for dysmenorrhoea

Marjoribanks¹,

Proctor²,

Farquhar³

et al. 2010

Cochrane Database of Systematic Reviews

152

110

View full text Add to dashboard Cite

Effect of a Psidii guajavae folium extract in the treatment of primary dysmenorrhea: A randomized clinical trial

Cited by 40 publications

References 24 publications

Spasmolytic effect of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract on rat isolated uterine horns

Spasmolytic effect of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract on rat isolated uterine horns

Plasma metabolic profiling of normal and dysmenorrhea syndrome rats and the effects of Xiang–Fu–Si–Wu Decoction intervention

Nonsteroidal anti-inflammatory drugs for dysmenorrhoea

Contact Info

Product

Resources

About