Effect of a selective OX1R antagonist on food intake and body weight in two strains of rats that differ in susceptibility to dietary-induced obesity

White, Christy L.; Ishii, Yasuyuki; Mendoza, T.; Upton, Neil; Stasi, Luigi; Bray, George A.; York, David A.

doi:10.1016/j.peptides.2005.03.042

Cited by 48 publications

(32 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[35] In rats, it reduces food intake in a more effective manner in a strain more susceptible to dietary-induced obesity. [67] Prud'homme et al showed that the orexin system is involved in the modulation of the olfactory bulb responses to food odor. [68] They found that blockade of both OX1R/OX2R with almorexant in fasted rats induced similar behavioral and Fos responses to food odor exposure than satiated rats.…”

Section: Neurophysiology Of the Orexin Systemmentioning

confidence: 99%

Orexin Receptor Antagonists: A New Concept In CNS Disorders?

et al. 2010

View full text Add to dashboard Cite

Section: Neurophysiology Of the Orexin Systemmentioning

confidence: 99%

Orexin Receptor Antagonists: A New Concept In CNS Disorders?

et al. 2010

View full text Add to dashboard Cite

“…injections (Ishii et al, 2005b). In addition, systemic injections of SB 334867 decrease both home-cage food consumption (Haynes et al, 2000;Ishii et al, 2005a;White et al, 2005) and body weight (Haynes et al, 2000) for at least 24 h after these injections. Together, it is unlikely that the lack of effect of SB 334867 on hypocretin 1-, pelletpriming or yohimbine-induced reinstatement of food seeking is due to our 45-60 min injection-test interval or the use of doses that are too low to have an impact on food-seeking behaviours.…”

mentioning

confidence: 99%

Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats

2008

View full text Add to dashboard Cite

Background and purpose:Many studies have demonstrated a role of hypocretin 1 (orexin 1) receptors in home-cage food consumption in rodents. However, the role of these receptors in operant food self-administration or relapse to food seeking in animal models is unknown. Experimental approach: In Experiment 1, we trained food-restricted rats (16-20 g per day) to lever press for high-fat (35%) pellets (3-6 h per day, every other day). We then tested the effect of the hypocretin 1 receptor antagonist SB 334867 (10, 20 mg kg À1 , i.p) on pellet self-administration. In Experiment 2, we trained rats to self-administer the food pellets, and following extinction of the food-reinforced responding, we tested the effect of hypocretin 1 (3 and 6 mg, i.c.v) on reinstatement of foodseeking and the effect of SB 334867 on this reinstatement. In Experiment 3, we tested the effect of SB 334867 on reinstatement induced by non-contingent pellet exposure (pellet-priming) or the pharmacological stressor yohimbine (2 mg kg À1 , i.p). Key results: SB 334867 attenuated high-fat pellet self-administration. In contrast, SB 334867 had no effect on reinstatement of lever presses induced by hypocretin 1, pellet-priming or yohimbine. Conclusions and implications: These data indicate that during dieting, hypocretin 1 receptors contribute to operant high-fat pellet self-administration, but not to relapse to food seeking induced by acute re-exposure to the food itself or by the induction of a stress-like state.

show abstract

“…The majority of studies investigating OM and S5B rats have focused on the response to the adaptation to a HFD, which occurs following the consumption of HFD for at least 14 days (19,26,27,(37)(38)(39)(47)(48)(49)(50). In the current series of experiments, OM and S5B rats were fed a standard chow diet, which allowed for the investigation of innate differences between these two strains on the preference for fatty acid and sucrose solutions, expression of fatty acid receptors on the tongue, and the ability of CD36 on the tongue to modulate the preference for fatty acids.…”

mentioning

confidence: 99%

Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue

Chen

Bench

Schreiber

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

Chen CS, Bench EM, Allerton TD, Schreiber AL, Arceneaux KP 3rd, Primeaux SD. Preference for linoleic acid in obesity-prone and obesityresistant rats is attenuated by the reduction of CD36 on the tongue. Am J Physiol Regul Integr Comp Physiol 305: R1346-R1355, 2013. First published October 23, 2013 doi:10.1152/ajpregu.00582.2012.-Differential sensing of dietary fat and fatty acids by the oral cavity is proposed to regulate the susceptibility to obesity. In the current experiments, animals that differ in their susceptibility to obesity were used to investigate the influence of the oral cavity on the preference for the polyunsaturated fatty acid, linoleic acid. In experiment 1, the preference for differing concentrations of linoleic acid was determined in obesity-prone Osborne-Mendel (OM) and obesity-resistant S5B/Pl (S5B) rats. The preference threshold for linoleic acid was lower in S5B rats, compared with OM rats. To determine whether differences in linoleic acid preference threshold were related to innate strain differences in the fatty acid receptors on the tongue, the expression of GPR120, GPR40, and CD36 on the circumvallate papillae were assessed in OM and S5B rats. Results indicated that the expression of CD36, GPR40, and GPR120 did not differ between these two strains. Numerous studies have examined the role of CD36 on fat intake; therefore, in experiment 3, RNA interference was used to decrease the expression of CD36 on the tongues of OM and S5B rats, and the effect of decreased CD36 expression on linoleic acid preference was determined. CD36 siRNA attenuated linoleic acid preference for the most preferred concentration in both OM and S5B rats. Overall, these data indicate that there are innate differences in the preference threshold for linoleic acid in obesity-prone and obesity-resistant rats. Experimentally reducing the expression of CD36 on the circumvallate papillae attenuated the preference for linoleic acid in both strains. preference threshold; obesity-prone; obesity-resistant; CD36; taste CONSUMPTION OF AN ENERGY-DENSE, high-fat diet has been associated with an increased risk for developing obesity (23). The detection of dietary fat and subsequent fat intake are mediated by input from the oral cavity and by postingestive effects (12). The ability to sense dietary fat in the oral cavity has two main functions: 1) mediation of the cephalic phase response and 2) regulation of food intake (12, 31). Differences in fat/fatty acid sensors in the oral cavity have been proposed as potential mechanisms contributing to the susceptibility of becoming obese. This is characterized by a subset of individuals who become obese on a high-fat diet (HFD) and another subset of individuals that are resistant to becoming obese when consuming a HFD (15,24,31,33). Understanding the detection and regulation of fat intake by fat/fatty acid sensors in the oral cavity may elucidate the mechanisms by which individuals develop preferences for high-fat foods, overconsume dietary fat, and subsequently become obese.Demonstration...

show abstract

Effect of a selective OX1R antagonist on food intake and body weight in two strains of rats that differ in susceptibility to dietary-induced obesity

Cited by 48 publications

References 44 publications

Orexin Receptor Antagonists: A New Concept In CNS Disorders?

Orexin Receptor Antagonists: A New Concept In CNS Disorders?

Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats

Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue

Contact Info

Product

Resources

About