Effect of a single dose of pimobendan on right ventricular and right atrial function in 11 healthy cats

Kost, Lukas; Glaus, T M; Diana, Alessia; Toaldo, Marco Baron

doi:10.1016/j.jvc.2021.08.006

Cited by 3 publications

(7 citation statements)

References 40 publications

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“…The second echocardiography exam MED started 21 (19)(20)(21)(22)(23)(24) min after the administration of medetomidine IM. Thereafter, cats received 2.25 (1-3) mg/kg S-ketamine IV prior to the epididymectomy.…”

Section: Resultsmentioning

confidence: 99%

“…Atipamezole was administered IM 62 (49-81) min after medetomidine and 20 (20-35) min after S-ketamine and resulted in the rapid and full reversal of sedation, the return of pink mucous membranes and no signs of excitation in all cats. The third echocardiography ATI started 22 (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31) min after atipamezole and 43 (35-51) min after S-ketamine administration.…”

Section: Resultsmentioning

confidence: 99%

“…Cats were examined in right and left lateral recumbency following a standard protocol and using an ultrasound machine (CX50, Philips Health Care, Horgen, Switzerland) equipped with a multifrequency (S12-4) phased-array transducer. Two-dimensional, M-Mode, colour, pulsed wave and continuous wave Doppler as well as tissue Doppler images and videoclips were obtained using methods described elsewhere by one of the authors [ 9 , 22 , 23 ]. Echocardiographic studies were anonymized and transferred to an external hard disk for subsequent analysis using a dedicated workstation (TOMTEC ARENA, TOMTEC, Unterschleissheim, Germany).…”

Section: Methodsmentioning

confidence: 99%

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Atipamezole Reverses Cardiovascular Changes Induced by High-Dose Medetomidine in Cats Undergoing Sedation for Semen Collection

Diggelmann,

Baron Toaldo,

Bektas

et al. 2023

Animals

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This study aimed at describing the change in echocardiographic variables after high-dose medetomidine and the reversal with atipamezole in six cats undergoing sedation for semen collection. Further cardiac Troponin I (cTnI) concentration and the effect of repeated sedation were assessed. Echocardiography was performed before and 20 min after sedation with 0.1 mg/kg medetomidine intramuscularly (IM) for urethral catheterisation. Prior to epididymectomy, S-ketamine was administered intravenously. Twenty minutes after reversal with 0.5 mg/kg atipamezole IM, the third echocardiography was performed. Sedation with medetomidine and reversal with atipamezole was repeated on day 7, 14, 21 and 28. Heart rate (HR) and rhythm were monitored throughout all sedations. On day 0 and 28 cTnI concentrations were measured before and after the procedure. After normality testing, the values were compared over time. The administration of medetomidine led to a marked reduction in HR, cardiac output and ventricular systolic function and a significant increase in left ventricular dimensions. Rhythm abnormalities, such as ventricular premature complexes and idioventricular rhythm, could be observed. The administration of atipamezole completely reversed sedation and the changes in haemodynamic variables. No significant increase in cTnI concentrations could be detected, although two out of six cats showed values above the reference range.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Atipamezole Reverses Cardiovascular Changes Induced by High-Dose Medetomidine in Cats Undergoing Sedation for Semen Collection

Diggelmann,

Baron Toaldo,

Bektas

et al. 2023

Animals

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“…In this region, we also observed characteristic group peaks associated with stretching vibrations of aromatic heptazine-derived repeating units between 900 and 1700 cm À1 . These included sp 2 C=N stretching modes at 1627 cm À1 and out-of-plane bending vibrations of sp 3 C-N bonds at frequencies of 1536, 1393, 1311, and 1229 cm À1 [14]. A sharp absorption peak located at approximately 800 cm À1 was attributed to the characteristic ring mode of tri-s-triazine cycles [15], and an absorption band at 881 cm À1 was attributed to the deformation mode of N-H in amino groups [13][14][15].…”

Section: Characterization Of the Sensing Materialsmentioning

confidence: 99%

“…In Japan, pimobendan is used with human patients [1]. Oral pimobendan is used for treating congestive heart failure in dogs and cats [2]. Pimobendan is used to treat chronic heart failure and is less effective in patients with old myocardial infarction compared with those with dilated cardiomyopathy or other heart diseases [3,4].…”

Section: Introductionmentioning

confidence: 99%

Gold–graphitic carbon nitride composite electrode for pimobendan detection

Luk,

Chang,

et al. 2023

J Chinese Chemical Soc

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IntroductionHeart failure can lead to death and hospitalization, especially among older adults, and pimobendan is used with human patients. We investigated the electrochemical behavior of Au/g‐C3N4 electrochemical sensors to detect the concentration of pimobendan.ExperimentalCharacterization of the materials was conducted using XRD, TEM, SEM, EDS and FTIR. Cyclic voltammetry (CV) was used to measure the concentration and redox properties of pimobendan.Result and DiscussionsAt a voltage of 0.05 V, a reduction peak appeared, indicating an association between pimobendan concentration (ranging from 0 to 55 μM) and reductive current. At low concentrations of pimobendan concentration from 0.0 to 1.3 μM, the linearity R2 = 0.9149 with a detection limit of 0.29 μM. Dopamine, epinephrine, and uric acid did not interfere with the detection of pimobendan.ConclusionsA composite sensing electrode consisting of 3% Au/g‐C3N4 was fabricated for the detection of pimobendan. A potential pimobendan sensing mechanism on 3% Au/g‐C3N4 was proposed on the basis of these findings.

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Fabrication of Gold-Graphitic Carbon Nitride Composite Electrode for the Detection of Pimobendan

Luk¹,

Chang²,

Wu³

2023

Preprint

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In this study, the preparation of the composite 3% Au/graphite-C3N4 (3% Au/g-C3N4) sensing material was prepared by doping 3% Au onto the surface of graphitic carbonitride (C3N4) for detection pimobendan. By the way of sensing materials characterization, the X-ray diffraction analysis (XRD) and transmission electron Microscope (TEM) were performed. The cyclic voltammetry (CV) was used to measure the concentration and redox properties of pimobendan. It can be seen that when the voltage value is 0.05 V, and a reduction peak was appeared and the pimobendan concentration (0 to 55 μM) has a relationship with the reduction current value. At low concentrations of pimobendan concentration from 0.0 to 0.8 μM, the linearity R2 = 0.9642 with a detection limit of 0.28 μM. A possible pimobendan sensing mechanism on 3% Au/g-C3N4 was proposed.

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Effect of a single dose of pimobendan on right ventricular and right atrial function in 11 healthy cats

Cited by 3 publications

References 40 publications

Atipamezole Reverses Cardiovascular Changes Induced by High-Dose Medetomidine in Cats Undergoing Sedation for Semen Collection

Atipamezole Reverses Cardiovascular Changes Induced by High-Dose Medetomidine in Cats Undergoing Sedation for Semen Collection

Gold–graphitic carbon nitride composite electrode for pimobendan detection

Fabrication of Gold-Graphitic Carbon Nitride Composite Electrode for the Detection of Pimobendan

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