Effect of a single early-gestational alcohol consumption on the insulin binding by immune cells of adult rats

Pállinger, Éva; Csaba, G.

doi:10.1007/s00011-005-1383-4

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…These models are advantageous because they allow for precise control over variables such as timing of exposure and early experience that cannot be controlled for in human studies (Streissguth et al., 1980; Malanga and Kosofsky, 1999; Costa et al., 2000; Berman and Hannigan, 2000; Welch‐Carre, 2005). Data from mammalian models support the findings in humans demonstrating the effects of ethanol on a range of physical, behavioral, and physiological processes including brain growth and neural development (Diaz and Samson, 1980; Hofmann et al., 2002; Zhou et al., 2005), neurotransmitter function (Costa et al., 2000; Guerri, 1998; Rubert et al., 2006; Druse et al., 2006), learning and memory (Arias and Gabriela Chotro, 2006; Dursun et al., 2006; Popovic et al., 2006; O’Callaghan et al., 2007), immune function (Jerrells, 1991; Giberson and Weinberg, 1992; Pallinger and Csaba, 2005; Aloe, 2006; Ping et al., 2007) and neuroendocrine function (Gabriel et al., 1998; Yang and Zoeller, 2002; Wilcoxon and Redei, 2004; Zhang et al., 2005; Chen et al., 2006).…”

supporting

confidence: 59%

Effects of Developmental Exposure to Ethanol on Caenorhabditis elegans

Davis

Rankin

2008

Alcoholism Clin & Exp Res

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Background: We investigated the effects of chronic ethanol exposure on physical development, reproduction, and life expectancy of Caenorhabditis elegans, a microscopic nematode worm. It has a small nervous system of 302 neurons and a short lifespan of 2 to 3 weeks.Methods: In this study, the worms were chronically exposed to varying concentrations of ethanol for different periods of their life: for their entire lifespan, during larval development only, and during adulthood only. In addition, the worms were exposed to ethanol acutely during different stages of embryonic development.Results: Chronic exposure to ethanol during larval development temporarily delayed physical growth, slowed development, delayed the onset of reproductive maturity, and decreased both reproductive fecundity and longevity. Chronic exposure to ethanol beginning when worms completed development and reached reproductive maturity resulted in reduced C. elegans body length, decreased reproductive fecundity, and life expectancy. Finally, acute embryonic exposure of C. elegans eggs to high concentrations of ethanol at different stages of development resulted in a lower probability of exposed eggs hatching into larval worms depending on when eggs were exposed during development. Furthermore, some of the worms that did hatch displayed distinct physical dysmorphologies as a consequence of acute ethanol exposure during embryonic development.Conclusions: These data suggest that exposing C. elegans to ethanol during critical development periods results in characteristic phenotypic outcomes. Thus, C. elegans offers a novel model for exploring the mechanisms by which ethanol exposure affects development.

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supporting

confidence: 59%

Effects of Developmental Exposure to Ethanol on Caenorhabditis elegans

Davis

Rankin

2008

Alcoholism Clin & Exp Res

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“…On the other hand there are several reports on the long‐term consequences of alcohol consumption, for example, a single 15% alcohol treatment during early gestation reduced histamine and triiodothyronine content (Csaba et al . 2005) and insulin binding (Pállinger & Csaba 2005) in the immune cells of adult animals. Prenatal alcohol exposure was reported to modify the endogenous opioid pain‐inhibitory system, significantly enhancing analgesia (Nelson et al .…”

Section: Resultsmentioning

confidence: 99%

PRECLINICAL STUDY: Perinatal alcohol exposure enhances nocistatin levels in adulthood

Tekes¹,

Hantos²,

Gyenge³

et al. 2007

Addiction Biology

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In earlier experiments perinatal hormonal imprinting by alcohol decreased the hormone content of immune cells for life. In the present study, both a single day (15% on the third postnatal day) and a long-term treatment schedule of alcohol exposure (3% for 21 days) of dams during lactation significantly (P < 0.01) enhanced endogenous levels of nocistatin in the blood plasma as well as in the cerebrospinal fluid of the offspring, measured in 3-month-old rats. Our data suggest that alcohol consumption during lactation can cause a life-long influence on nocistatin levels in the offspring and most likely modify nocistatin-related functions such as pain tolerance.

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“…However, the imprinting effect of alcohol also must not be underestimated. When alcohol was given for rats at the 3rd day of gestation, the offspring's immune cells in adult age produced significantly less insulin, than the controls [153]. There were expressed changes also in the offspring's serotonin production after treating the mother during late pregnancy or lactation [58].…”

Section: Alcohol and Immune Cellsmentioning

confidence: 95%

The Immuno-Endocrine System: Hormones, Receptors and Endocrine Function of Immune Cells. The Packed-Transport Theory

Csaba

2011

Advances in Neuroimmune Biology

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Immune cells (lymphocytes, monocytes and macrophages, granulocytes and mast cells) produce numerous hormones, store and secrete them. In addition these cells have receptors for hormones and signal transduction pathways. These functions are under the control of the central nervous system (neuro-immune regulation), and there is a dynamic multi-directional interaction within the neuroimmune circuitry. Considering the high amount of immune cells, their hormone production can rival to that of the "classical" endocrine glands. However, in contrast to the endocrine glands, which are in general mono-producers, 1.) the immune cells are poly-producers, the same cell can produce different hormones at the same time and also poly-receivers, having receptors for different hormones, 2.) immune cells are mobile and can transport the hormones in a packaged form, even though they are able to synthesize and secrete the hormones locally. 3.) immune cells have the capacity to recognize the site where their hormones are needed. It is proposed that under the control of the nervous system immune cells produce hormones for general regulation, for intrasystem regulation and for remote, local regulation. Hormone production is gender dependent. Receptors are affected by hormonal imprinting during the critical developmental periods of target cells and the imprinting influences also the hormone synthesis of immune cells for life. Some hormones can be demonstrated in the nucleus of mast cells, however their function is not known. The knockout of one hormone's gene disturbs hormone balance in immune cells. The importance of the packed-transport hypothesis is discussed.

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Effect of a single early-gestational alcohol consumption on the insulin binding by immune cells of adult rats

Cited by 6 publications

References 13 publications

Effects of Developmental Exposure to Ethanol on Caenorhabditis elegans

Effects of Developmental Exposure to Ethanol on Caenorhabditis elegans

PRECLINICAL STUDY: Perinatal alcohol exposure enhances nocistatin levels in adulthood

The Immuno-Endocrine System: Hormones, Receptors and Endocrine Function of Immune Cells. The Packed-Transport Theory

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