Effect of a single hemodialysis session on endothelial dysfunction

Errakonda, Prabhakar Reddy; Paladugu, Ramakrishna; Bitla, Aparna R.; Musturu, Suchitra M; Lakshman, J.; Pemmaraju, Srinivasa Rao V L N; Vishnubhotla, Sivakumar

doi:10.5301/jn.2010.4926

Cited by 18 publications

(22 citation statements)

References 38 publications

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“…These findings are opposite to data presented by Silva et al [18], who reported that the process of hemodialysis reduced oxidative stress and improved venous endothelial function as reflected by the improved endotheliumdependent venodilation test. In another clinical studies, hemodialysis-induced oxidative stress and endothelial dysfunction were described [19,20]. One can assume that hemodialysis-induced imbalance between the endothelial procoagulant and profibrinolytic activities may predispose to thromboembolic events in that group of patients [21].…”

Section: Discussionmentioning

confidence: 99%

Different Effect of Hemodialysis on Function of Human Arterial and Venous Endothelial Cells

et al. 2018

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Background/aims: Hemodialysis causes the systemic inflammatory response, which may affect the function of endothelial cells. Methods: We studied the effect of the serum obtained after a hemodialysis session, compared to serum collected before the start of the treatment, on the gene expression and secretory activity of arterial endothelial cells (AECs) and venous endothelial cells (VECs) in in vitro culture. Results: Serum collected at the end of the hemodialysis session increased expression of the studied genes in VECs, and at the same time decreased their expression in AECs. Secretory activity was increased in VEC: (interleukin-6 [IL-6] +29%, p < 0.05, von Willebrand factor +23%, p < 0.02; tissue plasminogen activator [t-PA] +35%, p < 0.002, t-PA/plasminogen activator inhibitor-1 [PAI-1] ratio + 57%, p < 0.005). In AEC, synthesis of IL-6 and vascular endothelial growth factor were reduced (–36%, p < 0.02, –34%, p < 0.05, respectively) and the tPA/PAI-1 ratio was increased (+22%, p < 0.01). Conclusions: Hemodialysis induces the inflammatory, procoagulant, and profibrinolytic activity of VEC, whereas suppression of AEC is observed at the same time. Video Journal Club ‘Cappuccino with Claudio Ronco’ at https://www.karger.com/Journal/ArticleNews/223997?sponsor=52

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Section: Discussionmentioning

confidence: 99%

Different Effect of Hemodialysis on Function of Human Arterial and Venous Endothelial Cells

et al. 2018

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“…CRP might not be the ideal marker to study inflammatory changes as a result of dialysis; however, Lp-PLA2 serves as a better biochemical marker to determine the effects of dialysis on inflammatory markers. 6,7 In this study, serum arginase activity was evaluated as another marker of CHD in HD patients. We found increased arginase activity in HD patients compared with control subjects.…”

Section: Discussionmentioning

confidence: 99%

“…5 Recently, lipoprotein-associated phospholipase A2 (Lp-PLA2) was proposed as a novel inflammatory and endothelial dysfunction marker in HD patients. 6,7 Lp-PLA2 is a potentially useful plasma biomarker associated with cardiovascular disease. 8,9 The enzyme, also known as plasma platelet-activating factor acetylhydrolase (PAF-AH), is a Ca þ2 independent enzyme and has two prominent biological activities.…”

Section: Introductionmentioning

confidence: 99%

Effects of Lipoprotein-Associated Phospholipase A2 on Arginase/Nitric Oxide Pathway in Hemodialysis Patients

et al. 2012

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Lipoprotein-associated phospholipase A2 (Lp-PLA2) and arginase are recently described inflammatory biomarkers associated with cardiovascular disease. In this study, we aimed to investigate the possible effects of serum Lp-PLA2 mass levels on arginase/nitric oxide (NO) pathway as a cardiovascular risk marker in hemodialysis (HD) patients. Fortythree HD patients and 15 healthy subjects were included in this study. Lipid profile, high sensitivity C-reactive protein (hs-CRP), albumin, creatinine, body mass index (BMI), Lp-PLA2 and total nitrite levels, and arginase activity were determined in serum samples from patients and control subjects. Lp-PLA2 levels were found to be positively correlated with arginase, triglycerides, total cholesterol, low-density lipoprotein-cholesterol, and age and negatively correlated with high-density lipoprotein-cholesterol and total nitrite levels, while there was no correlation with BMI and hs-CRP, albumin, and creatinine levels in HD patients. We conclude that elevated Lp-PLA2 mass levels may contribute to impaired arginase/ NO pathway in HD patients and that increased the arginase activity and Lp-PLA2 mass levels with decreased total nitrite levels seem to be useful biochemical markers in terms of reflecting endothelial dysfunction and associated cardiovascular risks in HD patients.

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“…[85], один сеанс ГД погіршував ендотелійзалежну ва-зодилатацію; в інших працях -остання не змінювалась [86] або покращувалась [87]. Вміст стабільних метаболітів NO після сеан-су ГД змінювався [88][89][90], а дослідження, прис вячені вивченню динаміки циркулюю чих ендотеліальних клітин як морфологічного маркера пошкодження ендотелію протягом ГД, поодинокі [91]. Наводяться дані про зниження активності NOS і L-аргініну в лімфоцитах у хворих після сеансу ГД [92].…”

Section: сучасні тенденції розвитку науки індуктори та інгібітори каunclassified

“…Наводяться дані про зниження активності NOS і L-аргініну в лімфоцитах у хворих після сеансу ГД [92]. Відомо, що в реалізації механізмів ЕД при ХХН чільне місце відводиться ОС [76], ін-тенсивність якого посилюється у хворих із діаліззалежною ХХН, очевидно, через ГД-індуковане порушення вільнорадикального гомеостазу, що підтверджено в цілій низці досліджень [88,89]. Разом з тим існують повідомлення про зниження проявів ОС внаслідок сеансу ГД [87,92].…”

Section: сучасні тенденції розвитку науки індуктори та інгібітори каunclassified

Calcification of Heart and Vessels in Chronic Kidney Disease: Problems of Etiology and Pathogenesis

Susla¹,

Gozhenko²,

Bergier³

et al. 2017

Fiziol Zh

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Effect of a single hemodialysis session on endothelial dysfunction

Cited by 18 publications

References 38 publications

Different Effect of Hemodialysis on Function of Human Arterial and Venous Endothelial Cells

Different Effect of Hemodialysis on Function of Human Arterial and Venous Endothelial Cells

Effects of Lipoprotein-Associated Phospholipase A2 on Arginase/Nitric Oxide Pathway in Hemodialysis Patients

Calcification of Heart and Vessels in Chronic Kidney Disease: Problems of Etiology and Pathogenesis

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