Peri-implant diseases have become one of the notable biological complications of post-rehabilitation with implant-supported restorations. Effective modalities of decontamination of biofilm deposits around implant surfaces are critical for the resolution of the inflammation. Air polishing is considered one of the recommended clinical methods for treating peri-implant diseases. This systematic review assessed clinical evidence on the efficacy of using air polishing technology for the management of peri-implant diseases, including peri-implant mucositis and peri-implantitis. Four electronic databases from January 1990 to December 2022 were searched to identify the relative human randomized clinical trials that applied air polishing for non-surgical and surgical treatment of peri-implant mucositis and peri-implantitis. Twelve articles were selected. For treating peri-implant mucositis, air polishing showed a comparable effect to ultrasonic scaling in the reduction of bleeding on probing (BOP) and probing pocket depth (PPD). The non-surgical approach of air polishing in treating periimplantitis varied in the reduction of BOP, PPD, and clinical attachment level (CAL) in evaluated studies. The air polishing in the surgical treatment of peri-implantitis was comparable to mechanical cleaning, implantoplasty, and Ti-brush, regarding the significant reduction of BOP, PPD, CAL, and improvement of bone level between baseline and follow-ups. The standardized mean difference with a 95% confidence interval of the studied parameters was estimated using the random effect model; however, statistical differences were not detected between air polishing and comparative modalities in the treatment of peri-implantitis. Within the limitations of this review, the application of air polishing did not result in more favorable outcomes in the treatment of peri-implant diseases compared to other modalities.