Effect of a subanesthetic dose of intravenous ketamine on hemodynamic response to skull-pin placement

Pilika, K.; Hoxha, Ariela; Demneri, M.; Saraçi, M.; Huti, Gentian

doi:10.1097/00003643-201006121-00405

Cited by 1 publication

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“…Subanaesthetic dose of ketamine was found to blunt the hemodynamic response to skull pin placement in one study. 12 But their influence on postinsufflation response and clinical recovery in laparoscopic surgeries is very much limited. Hence our primary outcome was to assess the quality of recovery following extubation, and the secondary outcome includes postinsufflation hemodynamic response, postoperative pain intensity, total opioid requirement, and look for side effects, if any.…”

Section: Introductionmentioning

confidence: 99%

Effect of Subanaesthetic Dose of Ketamine on Pneumoperitoneal Response and Clinical Recovery in Patients Undergoing Laparoscopy

Rajarajan¹,

Alarasan²,

Subramaniam³

et al. 2022

Turk J Anaesthesiol Reanim

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Objective: Although suppression of intraperitoneal gas insufflation response is possible with a higher dose of opioids, sedatives, and inhalational agents, delayed emergence and poor clinical recovery are still a matter of concern. Here our primary aim was to assess the quality of recovery and the secondary aim includes postinsufflation response, postoperative pain intensity, total opioid requirement, and looking for adverse effects, if any. Methods: This prospective randomized double-blinded controlled study was conducted among 75 American Society of Anesthesiologist physical status I and II patients scheduled for laparoscopic surgeries under general anaesthesia. Group 1 received injection tramadol 1 mg kg −1 iv −1 5 minutes after intubation. Similarly, groups 2 and 3 received 0.25 mg kg −1 and 0.5 mg kg −1 injection of ketamine iv, respectively. Intraperitoneal insufflation response was observed from the beginning of insufflation till 15 minutes. Clinical recovery was measured in terms of vigilance, cognition, orientation, and comfort. Postoperative pain intensity was assessed at varying movement activities using numerical rating scale pain score and with the total opioid requirement. The collected data were analyzed using three-way ANOVA. Results: Groups 1 and 2 had a fair clinical recovery. Postoperative pain intensity was least in group 2, and the postinsufflation mean arterial pressure was higher in groups 1 and 3. A total of 32% of participants had delirium in group 3. Conclusions: Clinical recovery and perioperative analgesia were better in ketamine group (0.25 mg kg −1 ) without any perturbations in intra-operative pneumoperitoneal response. Hence it can be considered an optimal adjuvant in laparoscopic surgeries.

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Section: Introductionmentioning

confidence: 99%