Effect of a sustained silver-releasing dressing on ulcers with delayed healing: the CONTOP study

Münter, Karl-Christian; Beele, Hilde; Russell, Linda; Crespi, A.; Gröchenig, Ernst; Basse, P; Alikadič, Nadja; Fraulin, Frankie Og; Dahl, Claus; Jemma, A

doi:10.12968/jowc.2006.15.5.26909

Cited by 102 publications

(89 citation statements)

References 10 publications

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“…No data were available at the time of this review to support the current widespread use of silver-containing dressings, confirming another recent review [81]. Although a single study had compared the use of a silver-containing dressing with usual care in a mixed population of chronic wounds, it was not included in this review because of lack of clear presentation of the subpopulation (8%) with diabetic foot ulcers, even though it was reported that there was no apparent effect on healing in this small group [82]. The group of agents for which there exists some evidence of effectiveness is the hydrogels, as has been noted previously [83,84], but further studies are required.…”

Section: Discussionsupporting

confidence: 66%

A systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetes

Hinchliffe

Valk

Apelqvist

et al. 2008

Diabetes Metab. Res. Rev.

203

132

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SummaryThe outcome of management of diabetic foot ulcers is poor and there is uncertainty concerning optimal approaches to management. We have undertaken a systematic review to identify interventions for which there is evidence of effectiveness. A search was made for reports of the effectiveness of interventions assessed in terms of healing, ulcer area or amputation in controlled clinical studies published prior to December 2006. Methodological quality of selected studies was independently assessed by two reviewers using Scottish Intercollegiate Guidelines Network (SIGN) criteria. Selected studies fell into the following categories: sharp debridement and larvae; antiseptics and dressings; chronic wound resection; hyperbaric oxygen (HBO); reduction of tissue oedema; skin grafts; electrical and magnetic stimulation and ultrasound. Heterogeneity of studies prevented pooled analysis of results. Of the 2251 papers identified, 60 were selected for grading following full text review. Some evidence was found to support hydrogels as desloughing agents and to suggest that a systemic (HBO) therapy may be effective. Topical negative pressure (TNP) may promote healing of post-operative wounds, and resection of neuropathic plantar ulcers may be beneficial. More information was needed to confirm the effectiveness and cost-effectiveness of these and other interventions. No data were found to justify the use of any other topically applied product or dressing, including those with antiseptic properties. Further evidence to substantiate the effect of interventions designed to enhance the healing of chronic ulcers is urgently needed. Until such evidence is available from robust trials, there is limited justification for the use of more expensive treatments and dressings.

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Section: Discussionsupporting

confidence: 66%

A systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetes

Hinchliffe

Valk

Apelqvist

et al. 2008

Diabetes Metab. Res. Rev.

203

132

View full text Add to dashboard Cite

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“…8 Munter reported that silver dressing supports faster healing of delayed healing wounds. 3 No adverse reaction was observed in the study group where as in the control group 23.33 % (7) patients had adverse reactions which included itching and hyperpigmentation (Table 16). …”

Section: Discussionmentioning

confidence: 89%

“…3 Epithelialization was more than 50% at the end of treatment. Caruso DM showed majority of wound treated with silver dressing decreased in size (70%) and increased epithelialization more than 50% with decreased exudates, decreased purulence and resolution of surface slough.…”

Section: Discussionmentioning

confidence: 95%

A comparative study of the effect on healing of ulcer using silver dressing

Khandelwal

Yadav

et al. 2016

Int Surg J

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“…In VLUs without a wound infection (HS 2), moist wound dressings (SoC) are applied [cf.4]. The number of weekly dressing changes is set to 2.5 in both HS 1 and 2 [7,9,18]. …”

Section: Methodsmentioning

confidence: 99%

“…It is assumed that the choice of dressing does not have an impact on ulcer recurrence. The chosen recurrence rate refers to antimicrobial and standard dressings [18]. 2 2

Further assumptions are presented in Appendix 2.

The transition probabilities can be found in Table 1:…”

Section: Methodsmentioning

confidence: 99%

Budget impact of antimicrobial wound dressings in the treatment of venous leg ulcers in the German outpatient care sector: a budget impact analysis

Gueltzow¹,

Khalilpour²,

Kolbe³

et al. 2018

Journal of Market Access & Health Policy

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Background: Hard-to-heal wounds are associated with high treatment costs and, in Germany, are mostly treated in the outpatient care sector. Wound dressings are the main cost-drivers in venous leg ulcer (VLU) care which prescription is budget-restricted. Objective: To determine to what extent the choice of antimicrobial dressing affects the spending in outpatient care by investigating the budget impact of the bioburden-reducing dressing Cutimed Sorbact. Methods: The budget impact analysis was performed comparing three different scenarios of the intervention mix of antimicrobial dressings. A Markov model was used to estimate the VLU progression during one year. The budget impact was determined by comparing the dressing and medicine resource use and costs of the three scenarios. Results: This analysis confirms the high treatment costs of VLU care. ScenarioA leads to a decreased resource use of antimicrobial dressings and results in 20.86% lower treatment costs after 12 months. The increased use of Cutimed Sorbact has a positive budget impact. Conclusion: This analysis indicates that the treatment of VLU patients may result in an exceedance of the budget per patient that is available to the treating practitioner. The choice of wound dressing, however, may positively affect the prescribers’ budget spending in outpatient care.

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Effect of a sustained silver-releasing dressing on ulcers with delayed healing: the CONTOP study

Abstract: This large-scale comparative real-life study shows that the silver foam dressing supports faster healing of delayed healing wounds.

Cited by 102 publications

References 10 publications

A systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetes

A systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetes

A comparative study of the effect on healing of ulcer using silver dressing

Budget impact of antimicrobial wound dressings in the treatment of venous leg ulcers in the German outpatient care sector: a budget impact analysis

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