Effect of a Synthetic Analogue of Vasopressin in Animals and in Patients With Diabetes Insipidus

Vavra, I.; Machová, Alena; Holeček, V; Cort, J. H.; Zaoral, M.; Šorm, F.

doi:10.1016/s0140-6736(68)90904-5

Cited by 169 publications

(58 citation statements)

References 13 publications

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“…Thirty min later, when urinary flow rate had decreased markedly, 20 &kg body wt DDAVP (Ferring Sveden) was infused iv over a period of 20 min. Even at such supramaximal doses, the drug has no significant vasoconstrictor effects (26). Clearance measurements as described above, were then performed for at least 3 hr.…”

Section: Clearance Measurements During and After The Infusion Of D D mentioning

confidence: 99%

Effect of Antidiuretic Hormone Upon Urinary Concentrating Ability and Medullary c-AMP Formation in Neonatal Piglets

et al. 1979

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SummaryIn 16 anesthetized piglets, the effects of I-deamino-8-D-arginine-vasopressin (DDAVP) upon urinary flow rate, relative urinary osrilolarity (U/P,,,,,,I), fractional water excretion (U/Pl,), fractional urca excretion (U/P,,,.,,/U/PI,), renal adenosine 3',5'-cyclic nlonophosphate (c-AMP) formation rate, and medullary c-AMP content were studied during the first 6 days of life. Glomerular filtration rate (GFR) was 0.19 + 0.09 ml/min/g kidney wt (means + SD) on day 1 and increased to 0.51 + 0.11 ml/min/g kidney wt on day 6. It was not affected by the application of 20 pg DDAVP/ kg body wt. On day 1, U/P,,,,,1(1.81 + 0.29), urinary flow rate (5.36 + 1.49 pl/n~in/g kidney wt), U/PI, (31.67 + 6.10) and U/ P,,,.,,/U/PI, (0.84 + 0.12) were not affected by DDAVP application. Fro111 day 2 onward, the reponse of these variables to application of DDAVP increased progressively. On day 6, the following responses were observed: Urinary flow rate decreased from 13.85 f. 7.02 pl/nlin/g kidney wt before DDAVP to 5.07 ? 2.19 pl/min/ g kidney wt after DDAVP. U/P,,,,I raised from 1.24 + 0.27 before DDAVP to 2.64 ? 0.17 after DDAVP. U/PI, increased fro111 36.85 + 13.11 before DDAVP to 109.39 + 22.00 after DDAVP. U/P,,,,,/U/P,, decreased from 0.75 ? 0.05 before DDAVP to 0.55 + 0.04 after DDAVP. These data indicate that the snlall solute permeability of the medullary collecting ducts becon~es increasingly sensitive to antidiuretic hormone (ADII) during this period. The increase in responsiveness of the urinary concentrating system with age was paralleled by the effect of DDAVP on renal c-AMP fornlation rate. In the diuretic control state, no correlation between renal c-AMP fornlation rate and the number of days was observed. llowever, after the application of DDAVP, the nephrogenic fraction of renal c-AMP excretion rate increased from 10.58 + 4.49 pnlole/min/g kidney wt on day 1 to 21.61 + 8.10 pmole/ n~in/g kidney wt on day 6. Similar results were observed with the nledullary c-AMP content. In diuretic control animals which had riot received DDAVP, the medullary c-AMP content ranged between 636 ? 257 pnlole/g wet wt on day 1 and 622 + 75 pmole/g wet wt on day 6. IIowever, in animals which had been infused with DDAVP, niedullary c-AMP content increased from 684 + 274 pnrole/g wet wt on day 1 to 1536 ? 316 pmole/g wet wt on day 6. SpeculationThe unresponsiveness of the medullary adenylatecyclase to AD11 in the newborn kidney might restrict, in addition to other parameters, the renal concentrating ability during the neonatal period.It is generally acknowledged that the concentrating ability of the newborn kidney is reduced in comparison to that of the mature kidney. In the past, this phenomenon was predominately attributed to the structural immaturity of the renal medulla (2, 22), to the reduced G F R and to the anabolic state of the neonatal metabolism, which together result in low filtration-, reabsorption-, and excretion rate of urea (5, 6). It was argued that in spite of the effects of ADH on the permeability of the collecting d...

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Section: Clearance Measurements During and After The Infusion Of D D mentioning

confidence: 99%

Effect of Antidiuretic Hormone Upon Urinary Concentrating Ability and Medullary c-AMP Formation in Neonatal Piglets

et al. 1979

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“…It is well known that an analogue of authentic arginine vasopressin (AVP), 1-deamino-[8-D-arginine] vasopressin(dDAVP), has a greater antidiuretic potency and a much less vasopressor activity than AVP (Huguennin et al, 1965;Vavra et al, 1968;Sawyer et al, 1974-a, b). Although the enhanced potency of dDAVP has been shown to be due to its longer plasma half-life (Edwards et al, 1973;Sawyer et al, 1974-a) and greater generation of renomedullary adenylate cyclase and cyclic AMP than those of AVP (Seif et al, 1978), mechanisms responsible for the prolonged plasma half-life of dDAVP have not yet been fully clarified.…”

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confidence: 99%

Resistance of 1-deamino-(8-D-arginine)-vasopressin to in vitro degradation as compared with arginine vasopressin.

et al. 1985

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“…An analogy may be found in ADH, where replacement of L-arginine by D-arginine in position 8 reduces pressor but not antidiuretic potency (10), and in ACTH where removal of C-terminal 14-39 abolishes corticotropic but enhances melanotropic activity (11) because of possible idiosyncratic or allergic reaction to intravenous injection of the chemically altered forms of native hGH, this type of experiment was not done. It is tempting to speculate that the increased retention of phosphorus seen in man with RCAMhGH and its plasmin digest is related to the enhanced activity of plasmin digests of native hGH (PD-hGH) when assayed in the rat by the tibia test (17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

“…A change in the structure of a peptide hormone which possesses several biologic properties may not influence all properties in the same way (10,11).…”

Section: Introductionmentioning

confidence: 99%

Anabolic actions of reduced and S-carbamidomethylated human growth hormone and its plasmin digest in man.

Heymsfield¹,

Bethel²,

Hall³

et al. 1977

J. Clin. Invest.

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A B ST RA CT Six children aged 12-15 yr, deficient in endogenous growth honnone, were each treated, after a 7-day control period, for 7 days with 0.0168, 0.052, and 0.168 U/kg body wt314 human growth (hGH) (doses A, B, and C, respectively) in separate metabolic balance studies. Doses B and C caused a dose-related retention of N, P, K, Na, and Cl in ratios of 1/0.069/ 4.5/7.5/5.6. These ratios indicate increments in masses of protoplasm/extracellular fluid (ECF)/bone in ratios of 1/2.0/ < 0.00 1.Three of the children were also treated with doses A, B, and C of reduced and carbamidomethylated hGH (RCAM-hGH). Doses B and C caused 1.2-2.8 times as much retention of N, P, and K, and 0.3-0.5 times as much retention of Na and Cl, as did the corresponding doses of hGH. The plasmin digest of RCAM-hGH gave results generally similar to RCAMhGH. For RCAM-hGH and its plasmin digest, N, P, K, Na, and Cl were retained in ratios of about 1/ 0.14/5.4/2.2/2.1, indicating increments of protoplasm/ ECF/bone of about 1/0.8/0.05.These findings indicate that reduction and carbamidomethylation alter the anabolic actions of hGH in man in both quantitative and qualitative manner. RCAM-hGH is more potent in stimulating enlargement of protoplasm and bone, and less potent in stimulating expansion of ECF, than is the native hormone. The profile of anabolic actions of RCAM-hGH in man does not appear to be fuirther altered by digestion with plasmin.

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Effect of a Synthetic Analogue of Vasopressin in Animals and in Patients With Diabetes Insipidus

Cited by 169 publications

References 13 publications

Effect of Antidiuretic Hormone Upon Urinary Concentrating Ability and Medullary c-AMP Formation in Neonatal Piglets

Effect of Antidiuretic Hormone Upon Urinary Concentrating Ability and Medullary c-AMP Formation in Neonatal Piglets

Resistance of 1-deamino-(8-D-arginine)-vasopressin to in vitro degradation as compared with arginine vasopressin.

Anabolic actions of reduced and S-carbamidomethylated human growth hormone and its plasmin digest in man.

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