Effect of a-Tocopherol Acetate on Dexamethasone Induced Experimental Insulin Resistance-role of Oxidative Stress

Biradar, Karnakumar V; Ramesh, H. P.; Malipatil, M. H.; Bhande, Rajshekhar M.; Biradar, Sanjivkumar D.

doi:10.13005/bbra/865

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…Dexamethasone (Dex), a synthetic glucocorticoid with anti-inflammatory and immunosuppressant properties has proffered broad therapeutic applications. "This is not without a setback; as glucose intolerance and reduced insulin sensitivity in vulnerable patients have been reported, but is dependent on the dose and frequency of its administration, which could cause diabetes mellitus" [8]. Apart from its clinical applications, Dex is widely employed to induce insulin resistance in animals and humans in research [9,10,11,12].…”

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confidence: 99%

Assessment of the Risk of Developing Cardiovascular Disease in Prediabetic and Diabetic Wistar Rats with Insulinaemia, in a Selected Model

Aleme

Amadi

2022

JOCAMR

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Introduction: This examination assessed the risk of developing cardiovascular disease in pre-diabetic and diabetes with insulinaemia in Wistar rats using the HOMA-IR model. The assessment solidified the role of Wistar rats in the evaluation model and took the blood analytes to screen for diabetes. Methodology: 84 male Wistar rats measuring 175g were isolated into fourteen groups of six animals each and dealt with high fat eating standard and acknowledged with dexamethasone which achieved diabetes. Group 1 animals were given feed and water. Group 2 animals got no treatment. Groups 3-5 were coordinated Glimepiride and Metformin, and Cinnamon independently while Groups 6-14 were administered 100mg/kg, 300mg/kg, and 500mg/kg of Ginger, Aloe Vera, and mix of Ginger and Aloe Vera exclusively. The concentrates were administered orally. Every illustration of blood serum and plasma was explored using Randox and Accubind packs and an autoanalyser to test for various biochemical and hematological limits. Results: The overall results revealed a colossal differentiation (p≤0.05) in the limits except for that of Na+. The 500mg/kg body weight part of the concentrate was ideal while there was much basic development in the HOMA-IR with potential gains of 0.94±0.04, 2.28±0.17 and 3.25±0.44 for the three sets. HOMA-IR is enticing over other models, as reported by other investigators. This assessment revealed that HOMA-IR works best in the management of diabetes in connection with various models. Contributions to Knowledge: HOMA-IR works best at predicting and managing DM. Administration of varying doses of the extracts to the Wistar rats helped in the control by ameliorating the effect of diabetes as seen in the return of some diabetic markers assayed. This research used Wistar rats in the evaluation of the HOMA-IR model. This research compared the blood analytes of non-diabetics, pre-diabetics, and diabetics in order to monitor the onset of diabetes and proffer possible solutions to enhance early detection and manage diabetes.

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Section: Introductionmentioning

confidence: 99%

Assessment of the Risk of Developing Cardiovascular Disease in Prediabetic and Diabetic Wistar Rats with Insulinaemia, in a Selected Model

Aleme

Amadi

2022

JOCAMR

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The Role Caspase-8 and DNA Methylation in patients with Ovarian Cancer: Relationship with Oxidative Stress and Inflammation

Hamzah

Jabbar

Almzaiel

2021

RJPT

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Background: Ovarian cancer (OC) is the most common cancer and a leading cause of death in women. It well known that suppress the apoptosis initiates tumor and its development. Oxidative stress, and inflammation showed to have a role in tumorigenesis. However, the mechanism still unclear. Methods: 90 females were involved in the current study. Blood samples were obtained from thirty healthy controls, thirty premenopausal women, and thirty postmenopausal women with primary diagnosis of ovarian cancer. Plasma SOD activity was determined by spectrophotometry method, plasma levels of 8-OHG, IL-8, and Cas-8 were measured by ELISA. methylation specific PCR (MSP PCR) was applied for measurements of un-methylation and methylation levels of Cas-8 gene. Result: The results showed a significant decrease in SOD activity in postmenopausal group compared to premenopausal women and control groups (P < 0.05). A significant increase in 8-OHG and IL-8 levels in both OC groups compared with control group (P < 0.05). Apoptosis were decreased through levels of Cas-8 in patients group compared to control group (P< 0.05). Also a high level methylation of Cas-8 gene was observed in plasma sample of patient groups compared to control group. Conclusions: low levels of Cas-8 and methylation of Cas-8 may be involved in OC carcinogenesis and consider as diagnostic marker. Oxidative stress-mediated inflammatory response and methylation of Cas-8, this may be for promoter hyper methylation in OC. Taken together, the result open new sight in strategy therapy for OC.

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Prevalance and role of Melatonin on PCOS in its treatment using Herbal Drugs

Ahamed

Sumitra

Chitra

2021

RJPT

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The polycystic ovarian syndrome is a convoluted endocrine disorder of the reproductive system which influences several girls with puberty and 6-8% of germinating women in endemic populations and displays a wide spectrum of clinical phenomenon. This disorder was first reported in 1935 as a synthetic clinical error for its associations with high androgen levels, hyperinsulinemia, and PCOS. The pineal hormone melatonin is known to regulate a mixture of central and peripheral actions related to circadian rhythms. It is a pleiotropic fragment, which plays a vital role in female reproduction as a capable free radical hunter and involves many gynecological and obstetrical pathology. PCOS is a compound condition for which the symptoms are irregular, and the cause is anonymous. Herbal products like Yastimadhu (Glycyrrhiza glabra), Kumari (Aloe vera), Tvaka (Cinnamomum Zeylanicum), Mostly the Ayurvedic drugs used for the PCOS, all are Vata-kapha shamaka. Neurological associated in pcos is still in the platform of research, no drugs melatonin an important modulator in pcos can be concentrated to cure pcos. Melatonin might be effective against neurological associate pcos. In ayurvedic way of treatment it can be cured with several natural drugs.

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Effect of a-Tocopherol Acetate on Dexamethasone Induced Experimental Insulin Resistance-role of Oxidative Stress

Cited by 4 publications

References 6 publications

Assessment of the Risk of Developing Cardiovascular Disease in Prediabetic and Diabetic Wistar Rats with Insulinaemia, in a Selected Model

Assessment of the Risk of Developing Cardiovascular Disease in Prediabetic and Diabetic Wistar Rats with Insulinaemia, in a Selected Model

The Role Caspase-8 and DNA Methylation in patients with Ovarian Cancer: Relationship with Oxidative Stress and Inflammation

Prevalance and role of Melatonin on PCOS in its treatment using Herbal Drugs

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