Effect of academic stress on serum cortisol level and CD4 cell count in young male postgraduate students in Okada, Nigeria

Ehiaghe, FA; De, Alok; Ositadima, MI; Ehiaghe, I.J.; Hb, Osadolor

doi:10.4314/ijbcs.v8i3.37

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…Another similar study conducted by Rajak et al 38 had shown a correlation between significantly decreased levels of cortisol and reduced stress. Ehiaghe et al 39 assessed serum cortisol in young male postgraduate students and found a significant increase in serum cortisol at 1st day of semester when compared with midway of semester and on last examination morning. These results show that cortisol levels increase in stressful conditions and when stressful event ends, cortisol level resume their normal levels.…”

Section: Discussionmentioning

confidence: 99%

The association between serum cortisol, thyroid profile, paraoxonase activity, arylesterase activity and anthropometric parameters of undergraduate students under examination stress

et al. 2021

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Stress caused due to examinations during any degree program and at any educational level has been observed at all levels so the present study was conducted to investigate the stress related to final examination in undergraduate students with reference to their academic performance. Fifty-four volunteers were divided into three groups, ( n = 18), according to their academic performance, that is, Group A with low CGPA (⩽2.99), Group B with average CGPA (⩾3.00–3.59) and Group C with high CGPA (⩾3.60) and blood samples (3 ml) were taken at three-time intervals, that is, pre-examination, during examination and post examination time interval, at the Department of Physiology, Government College University, Faisalabad. Anthropometric parameters like height, weight, blood pressure, heart rate and body mass index (BMI) were also determined. Blood cortisol and thyroid hormones (triiodothyronine, T3; thyroxine, T4) and thyroid stimulating hormone (TSH)) were measured using ELISA based technique. Arylesterase activity (ARE) and paraoxonase activity (PON-1) were also measured using colorimetric method. The results showed that overall cortisol level was increased at pre-examination and during examination time intervals as compared to the post examination time interval while PON-1 and ARE were significantly ( p < 0.05) decreased. With regards to T4 and TSH, a non-significant ( p < 0.05) difference was observed in pre and post examination time interval. It could be concluded from the current study that semester system examinations significantly ( p < 0.05) imposed stress in all students group at pre-examination interval as compare to post examination interval and this examination related stress was find more in the students already obtained low CGPA as compared to the other studied groups. Although, a correlation between academic performance and examinations stress in semester system was found but a large scale trial in multiple institutions throughout the Pakistan is required to exclude any socioeconomic factors because Pakistan belongs to developing country.

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Section: Discussionmentioning

confidence: 99%

The association between serum cortisol, thyroid profile, paraoxonase activity, arylesterase activity and anthropometric parameters of undergraduate students under examination stress

et al. 2021

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“…Absolute lymphocyte was determined using the sysmex automated Hematology analyzer as previously described by Ehiaghe et al (2014).…”

Section: Absolute Lymphocyte Count Estimationmentioning

confidence: 99%

Effect of ageing on some biophysical parameters amongst males in Benin City, Nigeria

Ehiaghe¹

2016

Int. J. Bio. Chem. Sci

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This study was designed to assess the effect of ageing on the CD4 + T cells count, testosterone, progesterone, and estrogen concentration in a view to evaluating the alterations associated with it. A total of 102 subjects aged between 20 and 80 years participated in the study.CD4 + T cell was estimated using Partec cyflow counter. Testosterone, progesterone and estrogen were determined by enzyme-linked immunosorbent assay methods. Our finding revealed a significant decrease in absolute lymphocyte count, CD4 + T cells count, progesterone, and testosterone concentration of the elderly males when compared with the young males (P < 0.05). Ageing induces a decrease in CD4 + T cells, progesterone and testosterone level which could be linked to the complications associated it.

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“…Several stressors including exercise-induced stress have been associated with a shift in cytokine production towards the anti-inflammatory patterns with cortisol and catecholamine elevations as the possible mediators [5]. It has been established that academic stress is inhibitory to the proliferation of CD 4 + T lymphocytes with the elevation of serum cortisol as a possible mediator [6]. It has also been reported that academic stress significantly increases serum cortisol level of Nigerian students [7].…”

Section: Introductionmentioning

confidence: 99%

The Expression Patterns of Some Pro-inflammatory and Anti-inflammatory Cytokines Genes Pre and Post Acute Exercise

Alfred¹

2017

IJI

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This study was designed to determine the expression patterns of some pro-inflammatory and anti-inflammatory cytokine genes in some young male undergraduates that passed through exhaustive exercise using the Bruce protocol for submaximal acute exercise as studies have shown that exhaustive exercise activates the release of multiple cytokine genes which modulate the immune responses of stressed individuals. Twenty five (25) healthy young male undergraduates with an average age of 24.3±3 years and body mass index of 22.7±1.8 (Kg/m 2) participated fully in the study. Blood samples were collected from the participants before commencement of the study, at 1 hour, 4 hours and 24 hours post exercise. Tumor necrosis factor α, interferon gamma and interleukin-10 genes expression patterns were detected using reverse transcriptase polymerase chain reaction methods. Serum cortisol (nmol/L) using enzyme-linked immunosorbent assay method. The study revealed that eleven (11) out of the twenty-five (25) participants had their tumor necrosis factor α genes up-regulated at 1 hour post exercise and sustained till 24 hours post exercise. Moreover, interferon gamma and interleukin-10 genes were up-regulated at 4 hours post exercise and sustained till 24 hours post exercise in most of the subjects. This study also observed that the cortisol level of the exercised subjects was significantly higher at 1 hour post acute exercise when compared with pre-exercise stage. Acute exercise was associated with an enhanced lymphocytic cell functions which are evidence in the up-regulation patterns of both lymphocytic pro-inflammatory cytokine and anti-inflammatory cytokine genes post exercise.

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Effect of academic stress on serum cortisol level and CD4 cell count in young male postgraduate students in Okada, Nigeria

Cited by 3 publications

References 10 publications

The association between serum cortisol, thyroid profile, paraoxonase activity, arylesterase activity and anthropometric parameters of undergraduate students under examination stress

The association between serum cortisol, thyroid profile, paraoxonase activity, arylesterase activity and anthropometric parameters of undergraduate students under examination stress

Effect of ageing on some biophysical parameters amongst males in Benin City, Nigeria

The Expression Patterns of Some Pro-inflammatory and Anti-inflammatory Cytokines Genes Pre and Post Acute Exercise

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