Effect of Acclimatization to Altitude on Susceptibility of Mice to Influenza A Virus Infection.

Berry, L. Joe; Rb, Mitchell; Rubenstein, David

doi:10.3181/00379727-88-21646

Cited by 21 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…En ratones inoculados con el virus de la influenza expuestos en una cámara hipobárica a una altura de 9.100 msnm se observó una menor carga viral que en sus controles de nivel del mar (log ID50 4,87 vs. 6,97; p < 0,01) 5 . Entre los inoculados a una altura simulada de 6.100 msnm sobrevivieron más los que luego de ser inoculados siguieron a ese nivel que los que descendieron a nivel del mar 6 . Atribuir la menor frecuencia de COVID-19 en la altura únicamente a la hipoxia hipobárica es inadecuado, pues en el Perú la frecuencia de enfermos con el virus de la influenza es solo un 30% menor en la altura 4 , mientras que con el SARS-CoV-2 es un 350% menor.…”

unclassified

En la altura la COVID-19 es menos frecuente: la experiencia del Perú

Accinelli

León-Abarca

2020

Archivos de Bronconeumología

View full text Add to dashboard Cite

unclassified

En la altura la COVID-19 es menos frecuente: la experiencia del Perú

Accinelli

León-Abarca

2020

Archivos de Bronconeumología

View full text Add to dashboard Cite

“…Protection attributed to altitude was also noted during the 2009 H1N1 influenza pandemic in Peru 46 and the 2006 H5N1 avian influenza epidemic in Indonesia 47 and Thailand 48 . Experiments with mice acclimatized to high altitude also showed enhanced resistance to a type A influenza strain 49 . As noted above, a major factor impacting physiological changes associated with altitude is hypobaric hypoxia 50 .…”

Section: Discussionmentioning

confidence: 96%

Altitude as a protective factor from COVID-19

Thomson

Casas

Guerrero

et al. 2020

Preprint

View full text Add to dashboard Cite

The COVID-19 pandemic had a delayed onset in South America compared to Asia (outside of China), Europe or North America. In spite of the presumed time advantage for the implementation of preventive measures to help contain its spread, the pandemic in that region followed growth rates that paralleled, and currently exceed, those observed several weeks before in Europe. Indeed, in early August, 2020, many countries in South and Central America presented among the highest rates in the world of COVID-19 confirmed cases and deaths per million inhabitants. Here, we have taken an ecological approach to describe the current state of the pandemic in Peru and its dynamics. Our analysis supports a protective effect of altitude from COVID-19 incidence and mortality. Further, we provide circumstantial evidence that internal migration through a specific land route is a significant factor progressively overriding the protection from COVID-19 afforded by high altitude. Finally, we show that protection by altitude is independent of poverty indexes and is inversely correlated with the prevalence in the population of risk factors associated with severe COVID-19, including hypertension and hypercholesterolemia. We discuss long-term multisystemic adaptations to hypobaric hypoxia as possible mechanisms that may explain the observed protective effect of high altitude from death from COVID-19.

show abstract

“…Evidence of such an increased resistance has been reported by Kalter and Teppermann (18), who found lower levels of virus, measured by hemagglutination titer, in lungs of mice subjected to hypoxia than in controls. Further, Berry et al (6) showed that mice acclimatized to altitude (hypoxia) either before or after infection with PR8 strain of influenza A are more resistant than controls, and that hypoxic mice maintained in hypoxia for the postinfection period are significantly more resistant than those maintained at normal atmosphere. These changes in resistance were interpreted to be the result of metabolic disturbances in host cells (6).…”

Section: Discussionmentioning

confidence: 99%

“…Various types of parabarosis have been examined for their effect on host-parasite reactions. For example, the propagation of influenza virus in the lungs of mice exposed to altitude (hypoxia) is greatly reduced (6,17,18), as is true of influenza virus cultured in cells in vitro under anaerobic conditions (19). Segre (21) observed that hog cholera virus, normally noncytopathogenic in kidney and testicle cells of swine and rabbit origin, was cytopathogenic under hyperbaric oxygen.…”

mentioning

confidence: 99%

Production of Interferon in Mice: Effect of Altered Gaseous Environments

Huang¹,

Gordon²

1968

Applied Microbiology

View full text Add to dashboard Cite

Effects of altered gaseous environments (parabarosis) on interferon production in mice were studied, with Newcastle disease virus (NDV) as the inducer. Increased levels of interferon in lung tissue were observed when mice were exposed to 11 % 02 in N2 for 3 days before and after, or only after, injection of NDV. However, serum interferon levels remained unchanged. Exposure of mice to 77% 02 for up to 7 days did not affect the response to interferon induction as assayed in lungs or sera. Interferon levels were significantly depressed in mice exposed to a simulated depth of 213 ft in seawater [with normal partial pressure of 02 (pO2) in N2] for 2 or 4 weeks. Whereas definite depression of interferon was also observed in mice maintained at a simulated altitude of 37,000 ft (with normal p02) for 2 weeks, those maintained at the same condition for 4 weeks showed a normal level of interferon. The results obtained with hypoxia are compatible with other reports on the influence of 02 tension on viral infection. The factors responsible for alterations observed in interferon level in mice kept in normal P02, but under altered pressure, have not yet been identified.

show abstract

Effect of Acclimatization to Altitude on Susceptibility of Mice to Influenza A Virus Infection.

Cited by 21 publications

References 0 publications

En la altura la COVID-19 es menos frecuente: la experiencia del Perú

En la altura la COVID-19 es menos frecuente: la experiencia del Perú

Altitude as a protective factor from COVID-19

Production of Interferon in Mice: Effect of Altered Gaseous Environments

Contact Info

Product

Resources

About